Noncanonical G recognition mediates KSRP regulation of let-7 biogenesis

7 pags, 4 figs, 1 tab. -- Material suplementario en la versión editorial

Detalles Bibliográficos
Autores: Nicastro, Giuseppe, García-Mayoral, M.F., Hollingworth, David, Kelly, Geoff, Martin, Stephen R., Briata, Paola, Gherzi, Roberto, Ramos, Andrés
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2012
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/248909
Acceso en línea:http://hdl.handle.net/10261/248909
Access Level:acceso abierto
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spelling Noncanonical G recognition mediates KSRP regulation of let-7 biogenesisNicastro, GiuseppeGarcía-Mayoral, M.F.Hollingworth, DavidKelly, GeoffMartin, Stephen R.Briata, PaolaGherzi, RobertoRamos, Andrés7 pags, 4 figs, 1 tab. -- Material suplementario en la versión editorialLet-7 is an important tumor-suppressive microRNA (miRNA) that acts as an on-off switch for cellular differentiation and regulates the expression of a set of human oncogenes. Binding of the human KSRP protein to let-7 miRNA precursors positively regulates their processing to mature let-7, thereby contributing to control of cell proliferation, apoptosis and differentiation. Here we analyze the molecular basis for KSRP–let-7 precursor selectivity and show how the third KH domain of the protein recognizes a G-rich sequence in the pre–let-7 terminal loop and dominates the interaction. The structure of the KH3–RNA complex explains the protein recognition of this noncanonical KH target sequence, and we demonstrate that the specificity of this binding is crucial for the functional interaction between the protein and the miRNA precursorThe work of A.R. has been funded by the Medical Research Council (MRC) grant U117574558 and the Wellcome Trust Grant WT082088MA. The work of S.R.M. and G.K. has been funded by MRC grants U117570592 and U117533887, respectively. The work of P.B. and R.G. has been supported by grants from the Association for International Cancer Research (10-0527) and Associazione Italiana per la Ricerca sul Cancro (I.G. 10090).Nature Publishing GroupMedical Research Council (UK)Wellcome TrustAssociation for International Cancer ResearchAssociazione Italiana per la Ricerca sul CancroConsejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]2021202120122021info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionhttp://hdl.handle.net/10261/248909reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Ingléshttps://doi.org/10.1038/nsmb.2427Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/2489092026-05-22T06:33:51Z
dc.title.none.fl_str_mv Noncanonical G recognition mediates KSRP regulation of let-7 biogenesis
title Noncanonical G recognition mediates KSRP regulation of let-7 biogenesis
spellingShingle Noncanonical G recognition mediates KSRP regulation of let-7 biogenesis
Nicastro, Giuseppe
title_short Noncanonical G recognition mediates KSRP regulation of let-7 biogenesis
title_full Noncanonical G recognition mediates KSRP regulation of let-7 biogenesis
title_fullStr Noncanonical G recognition mediates KSRP regulation of let-7 biogenesis
title_full_unstemmed Noncanonical G recognition mediates KSRP regulation of let-7 biogenesis
title_sort Noncanonical G recognition mediates KSRP regulation of let-7 biogenesis
dc.creator.none.fl_str_mv Nicastro, Giuseppe
García-Mayoral, M.F.
Hollingworth, David
Kelly, Geoff
Martin, Stephen R.
Briata, Paola
Gherzi, Roberto
Ramos, Andrés
author Nicastro, Giuseppe
author_facet Nicastro, Giuseppe
García-Mayoral, M.F.
Hollingworth, David
Kelly, Geoff
Martin, Stephen R.
Briata, Paola
Gherzi, Roberto
Ramos, Andrés
author_role author
author2 García-Mayoral, M.F.
Hollingworth, David
Kelly, Geoff
Martin, Stephen R.
Briata, Paola
Gherzi, Roberto
Ramos, Andrés
author2_role author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Medical Research Council (UK)
Wellcome Trust
Association for International Cancer Research
Associazione Italiana per la Ricerca sul Cancro
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
description 7 pags, 4 figs, 1 tab. -- Material suplementario en la versión editorial
publishDate 2012
dc.date.none.fl_str_mv 2012
2021
2021
2021
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/248909
url http://hdl.handle.net/10261/248909
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv https://doi.org/10.1038/nsmb.2427
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Nature Publishing Group
publisher.none.fl_str_mv Nature Publishing Group
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,811543

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