Improving Quality of Life Through Supervised Exercise in Oncology: A Systematic Review and Meta-Analysis of Randomized Trials in Breast and Prostate Cancer

Background: Cancer treatments often reduce quality of life (QoL), and non-pharmacological options are limited. Supervised exercise shows promise, but its effectiveness across exercise types and patient subgroups is unclear. Objective: This study aimed to assess the impact of supervised exercise on Q...

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Autores: Cano Uceda, Arturo, De Sousa De Sousa, Luis, Bueno Fermoso, Rebeca, Rozalén Bustín, Manuel, Lucio Allende, Carmen, Barba Ruiz, Manuel, Sánchez Barroso, Lara, Maté Muñoz, José Luis, García Fernández, Pablo
Tipo de recurso: artículo
Fecha de publicación:2025
País:España
Institución:Universidad Complutense de Madrid (UCM)
Repositorio:Docta Complutense
Idioma:inglés
OAI Identifier:oai:docta.ucm.es:20.500.14352/126417
Acceso en línea:https://hdl.handle.net/20.500.14352/126417
Access Level:acceso abierto
Palabra clave:615.8
supervised exercise
quality of life
breast cancer
prostate cancer
Ciencias Biomédicas
3213.11 Fisioterapia
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spelling Improving Quality of Life Through Supervised Exercise in Oncology: A Systematic Review and Meta-Analysis of Randomized Trials in Breast and Prostate CancerCano Uceda, ArturoDe Sousa De Sousa, LuisBueno Fermoso, RebecaRozalén Bustín, ManuelLucio Allende, CarmenBarba Ruiz, ManuelSánchez Barroso, LaraMaté Muñoz, José LuisGarcía Fernández, Pablo615.8supervised exercisequality of lifebreast cancerprostate cancerCiencias Biomédicas3213.11 FisioterapiaBackground: Cancer treatments often reduce quality of life (QoL), and non-pharmacological options are limited. Supervised exercise shows promise, but its effectiveness across exercise types and patient subgroups is unclear. Objective: This study aimed to assess the impact of supervised exercise on QoL in breast and prostate cancer patients, considering exercise type, duration, and patient characteristics. Methods: A systematic review and meta-analysis including 26 randomized controlled trials (RCTs) and approximately 3500 participants was conducted according to PRISMA guidelines. PubMed, Web of Science, PEDro, SciELO, Cochrane, and Scopus were searched for randomized controlled trials (RCTs) published between 2014 and 2024. Eligible studies involved adults with breast or prostate cancer undergoing supervised exercise versus usual care or unsupervised activity. Risk of bias was assessed with the Cochrane RoB 2.0 tool, methodological quality with the PEDro scale, and certainty of evidence using the GRADE approach. Results: Supervised exercise was associated with significant improvements in QoL (SMD = 0.46; 95% CI: 0.22–0.70; p < 0.001), with considerable heterogeneity (I2 = 91.5%). Combined programs had the greatest effect (SMD = 0.77), followed by high-intensity interval training (HIIT) (SMD = 0.30). Shorter interventions (≤12 weeks) yielded larger improvements. Effects were more consistent in women with breast cancer. Overall, the certainty of the evidence was low. Conclusions: Supervised therapeutic exercise is associated with significant improvements in QoL in breast and prostate cancer patients. Combined and well-structured programs, particularly of short duration, appear especially beneficial. These findings support the integration of supervised exercise into standard oncological care. Further research should explore long-term sustainability and optimize interventions for specific patient profiles.MDPIUniversidad Complutense de Madrid20252025-11-2020252025-11-20journal articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/20.500.14352/126417reponame:Docta Complutenseinstname:Universidad Complutense de Madrid (UCM)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2Attribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:docta.ucm.es:20.500.14352/1264172026-06-02T12:44:21Z
dc.title.none.fl_str_mv Improving Quality of Life Through Supervised Exercise in Oncology: A Systematic Review and Meta-Analysis of Randomized Trials in Breast and Prostate Cancer
title Improving Quality of Life Through Supervised Exercise in Oncology: A Systematic Review and Meta-Analysis of Randomized Trials in Breast and Prostate Cancer
spellingShingle Improving Quality of Life Through Supervised Exercise in Oncology: A Systematic Review and Meta-Analysis of Randomized Trials in Breast and Prostate Cancer
Cano Uceda, Arturo
615.8
supervised exercise
quality of life
breast cancer
prostate cancer
Ciencias Biomédicas
3213.11 Fisioterapia
title_short Improving Quality of Life Through Supervised Exercise in Oncology: A Systematic Review and Meta-Analysis of Randomized Trials in Breast and Prostate Cancer
title_full Improving Quality of Life Through Supervised Exercise in Oncology: A Systematic Review and Meta-Analysis of Randomized Trials in Breast and Prostate Cancer
title_fullStr Improving Quality of Life Through Supervised Exercise in Oncology: A Systematic Review and Meta-Analysis of Randomized Trials in Breast and Prostate Cancer
title_full_unstemmed Improving Quality of Life Through Supervised Exercise in Oncology: A Systematic Review and Meta-Analysis of Randomized Trials in Breast and Prostate Cancer
title_sort Improving Quality of Life Through Supervised Exercise in Oncology: A Systematic Review and Meta-Analysis of Randomized Trials in Breast and Prostate Cancer
dc.creator.none.fl_str_mv Cano Uceda, Arturo
De Sousa De Sousa, Luis
Bueno Fermoso, Rebeca
Rozalén Bustín, Manuel
Lucio Allende, Carmen
Barba Ruiz, Manuel
Sánchez Barroso, Lara
Maté Muñoz, José Luis
García Fernández, Pablo
author Cano Uceda, Arturo
author_facet Cano Uceda, Arturo
De Sousa De Sousa, Luis
Bueno Fermoso, Rebeca
Rozalén Bustín, Manuel
Lucio Allende, Carmen
Barba Ruiz, Manuel
Sánchez Barroso, Lara
Maté Muñoz, José Luis
García Fernández, Pablo
author_role author
author2 De Sousa De Sousa, Luis
Bueno Fermoso, Rebeca
Rozalén Bustín, Manuel
Lucio Allende, Carmen
Barba Ruiz, Manuel
Sánchez Barroso, Lara
Maté Muñoz, José Luis
García Fernández, Pablo
author2_role author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidad Complutense de Madrid
dc.subject.none.fl_str_mv 615.8
supervised exercise
quality of life
breast cancer
prostate cancer
Ciencias Biomédicas
3213.11 Fisioterapia
topic 615.8
supervised exercise
quality of life
breast cancer
prostate cancer
Ciencias Biomédicas
3213.11 Fisioterapia
description Background: Cancer treatments often reduce quality of life (QoL), and non-pharmacological options are limited. Supervised exercise shows promise, but its effectiveness across exercise types and patient subgroups is unclear. Objective: This study aimed to assess the impact of supervised exercise on QoL in breast and prostate cancer patients, considering exercise type, duration, and patient characteristics. Methods: A systematic review and meta-analysis including 26 randomized controlled trials (RCTs) and approximately 3500 participants was conducted according to PRISMA guidelines. PubMed, Web of Science, PEDro, SciELO, Cochrane, and Scopus were searched for randomized controlled trials (RCTs) published between 2014 and 2024. Eligible studies involved adults with breast or prostate cancer undergoing supervised exercise versus usual care or unsupervised activity. Risk of bias was assessed with the Cochrane RoB 2.0 tool, methodological quality with the PEDro scale, and certainty of evidence using the GRADE approach. Results: Supervised exercise was associated with significant improvements in QoL (SMD = 0.46; 95% CI: 0.22–0.70; p < 0.001), with considerable heterogeneity (I2 = 91.5%). Combined programs had the greatest effect (SMD = 0.77), followed by high-intensity interval training (HIIT) (SMD = 0.30). Shorter interventions (≤12 weeks) yielded larger improvements. Effects were more consistent in women with breast cancer. Overall, the certainty of the evidence was low. Conclusions: Supervised therapeutic exercise is associated with significant improvements in QoL in breast and prostate cancer patients. Combined and well-structured programs, particularly of short duration, appear especially beneficial. These findings support the integration of supervised exercise into standard oncological care. Further research should explore long-term sustainability and optimize interventions for specific patient profiles.
publishDate 2025
dc.date.none.fl_str_mv 2025
2025-11-20
2025
2025-11-20
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/20.500.14352/126417
url https://hdl.handle.net/20.500.14352/126417
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Docta Complutense
instname:Universidad Complutense de Madrid (UCM)
instname_str Universidad Complutense de Madrid (UCM)
reponame_str Docta Complutense
collection Docta Complutense
repository.name.fl_str_mv
repository.mail.fl_str_mv
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