Biosensors Integration in blood-brain barrier-on-a-chip: emerging platform for monitoring neurodegenerative diseases

Over the most recent decades, the development of new biological platforms to study disease progression and drug efficacy has been of great interest due to the high increase in the rate of neurodegenerative diseases (NDDs). Therefore, blood–brain barrier (BBB) as an organ-on-a-chip (OoC) platform to...

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Autores: Mir, Mònica, Palma Florez, Sujey, Lagunas, Anna, López-Martínez, M. José, Samitier i Martí, Josep
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2022
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/214346
Acceso en línea:https://hdl.handle.net/2445/214346
Access Level:acceso abierto
Palabra clave:Elèctrodes
Biosensors
Biotecnologia
Electrodes
Biotechnology
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spelling Biosensors Integration in blood-brain barrier-on-a-chip: emerging platform for monitoring neurodegenerative diseasesMir, MònicaPalma Florez, SujeyLagunas, AnnaLópez-Martínez, M. JoséSamitier i Martí, JosepElèctrodesBiosensorsBiotecnologiaElectrodesBiosensorsBiotechnologyOver the most recent decades, the development of new biological platforms to study disease progression and drug efficacy has been of great interest due to the high increase in the rate of neurodegenerative diseases (NDDs). Therefore, blood–brain barrier (BBB) as an organ-on-a-chip (OoC) platform to mimic brain-barrier performance could offer a deeper understanding of NDDs as well as a very valuable tool for drug permeability testing for new treatments. A very attractive improvement of BBB-oC technology is the integration of detection systems to provide continuous monitoring of biomarkers in real time and a fully automated analysis of drug permeably, rendering more efficient platforms for commercialization. In this Perspective, an overview of the main BBB-oC configurations is introduced and a critical vision of the BBB-oC platforms integrating electronic read out systems is detailed, indicating the strengths and weaknesses of current devices, proposing the great potential for biosensors integration in BBB-oC. In this direction, we name potential biomarkers to monitor the evolution of NDDs related to the BBB and/or drug cytotoxicity using biosensor technology in BBB-oC.American Chemical Society2024202420222024info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion11 p.application/pdfapplication/pdfhttps://hdl.handle.net/2445/214346Articles publicats en revistes (Enginyeria Electrònica i Biomèdica)reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésReproducció del document publicat a: https://doi.org/10.1021/acssensors.2c00333ACS Sensors, 2022, vol. 7, num.5, p. 1237-1247https://doi.org/10.1021/acssensors.2c00333cc-by (c) Mir, Mònica, et al., 2022http://creativecommons.org/licenses/by/3.0/es/info:eu-repo/semantics/openAccessoai:recercat.cat:2445/2143462026-05-29T05:05:01Z
dc.title.none.fl_str_mv Biosensors Integration in blood-brain barrier-on-a-chip: emerging platform for monitoring neurodegenerative diseases
title Biosensors Integration in blood-brain barrier-on-a-chip: emerging platform for monitoring neurodegenerative diseases
spellingShingle Biosensors Integration in blood-brain barrier-on-a-chip: emerging platform for monitoring neurodegenerative diseases
Mir, Mònica
Elèctrodes
Biosensors
Biotecnologia
Electrodes
Biosensors
Biotechnology
title_short Biosensors Integration in blood-brain barrier-on-a-chip: emerging platform for monitoring neurodegenerative diseases
title_full Biosensors Integration in blood-brain barrier-on-a-chip: emerging platform for monitoring neurodegenerative diseases
title_fullStr Biosensors Integration in blood-brain barrier-on-a-chip: emerging platform for monitoring neurodegenerative diseases
title_full_unstemmed Biosensors Integration in blood-brain barrier-on-a-chip: emerging platform for monitoring neurodegenerative diseases
title_sort Biosensors Integration in blood-brain barrier-on-a-chip: emerging platform for monitoring neurodegenerative diseases
dc.creator.none.fl_str_mv Mir, Mònica
Palma Florez, Sujey
Lagunas, Anna
López-Martínez, M. José
Samitier i Martí, Josep
author Mir, Mònica
author_facet Mir, Mònica
Palma Florez, Sujey
Lagunas, Anna
López-Martínez, M. José
Samitier i Martí, Josep
author_role author
author2 Palma Florez, Sujey
Lagunas, Anna
López-Martínez, M. José
Samitier i Martí, Josep
author2_role author
author
author
author
dc.subject.none.fl_str_mv Elèctrodes
Biosensors
Biotecnologia
Electrodes
Biosensors
Biotechnology
topic Elèctrodes
Biosensors
Biotecnologia
Electrodes
Biosensors
Biotechnology
description Over the most recent decades, the development of new biological platforms to study disease progression and drug efficacy has been of great interest due to the high increase in the rate of neurodegenerative diseases (NDDs). Therefore, blood–brain barrier (BBB) as an organ-on-a-chip (OoC) platform to mimic brain-barrier performance could offer a deeper understanding of NDDs as well as a very valuable tool for drug permeability testing for new treatments. A very attractive improvement of BBB-oC technology is the integration of detection systems to provide continuous monitoring of biomarkers in real time and a fully automated analysis of drug permeably, rendering more efficient platforms for commercialization. In this Perspective, an overview of the main BBB-oC configurations is introduced and a critical vision of the BBB-oC platforms integrating electronic read out systems is detailed, indicating the strengths and weaknesses of current devices, proposing the great potential for biosensors integration in BBB-oC. In this direction, we name potential biomarkers to monitor the evolution of NDDs related to the BBB and/or drug cytotoxicity using biosensor technology in BBB-oC.
publishDate 2022
dc.date.none.fl_str_mv 2022
2024
2024
2024
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/214346
url https://hdl.handle.net/2445/214346
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.1021/acssensors.2c00333
ACS Sensors, 2022, vol. 7, num.5, p. 1237-1247
https://doi.org/10.1021/acssensors.2c00333
dc.rights.none.fl_str_mv cc-by (c) Mir, Mònica, et al., 2022
http://creativecommons.org/licenses/by/3.0/es/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc-by (c) Mir, Mònica, et al., 2022
http://creativecommons.org/licenses/by/3.0/es/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 11 p.
application/pdf
application/pdf
dc.publisher.none.fl_str_mv American Chemical Society
publisher.none.fl_str_mv American Chemical Society
dc.source.none.fl_str_mv Articles publicats en revistes (Enginyeria Electrònica i Biomèdica)
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.81155

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