Predictors and changes of physical activity in idiopathic pulmonary fibrosis

Background Different clinical predictors of physical activity (PA) have been described in idiopathic pulmonary fibrosis (IPF), but studies are lacking evaluating the potential role of muscle strength and anxiety and depression symptoms in PA limitation. Moreover, little is known about the impact of...

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Autores: Badenes Bonet, Diana, Rodó Pin, Anna, Castillo Villegas, Diego, Vicens Zygmunt, Vanesa, Bermudo, Guadalupe, Hernández González, Fernanda, Portillo, Karina, Martínez Llorens, Juana, Chalela, Roberto, Caguana, Oswaldo, Sellarés Torres, Jacobo, Molina Molina, María, Duran, Xavier, 1959-, Gea Guiral, Joaquim, Rodríguez Chiaradia, Diego Agustín, Balcells, Eva
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2022
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/189562
Acceso en línea:https://hdl.handle.net/2445/189562
Access Level:acceso abierto
Palabra clave:Pronòstic mèdic
Fibrosi pulmonar
Prognosis
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spelling Predictors and changes of physical activity in idiopathic pulmonary fibrosisBadenes Bonet, DianaRodó Pin, AnnaCastillo Villegas, DiegoVicens Zygmunt, VanesaBermudo, GuadalupeHernández González, FernandaPortillo, KarinaMartínez Llorens, JuanaChalela, RobertoCaguana, OswaldoSellarés Torres, JacoboMolina Molina, MaríaDuran, Xavier, 1959-Gea Guiral, JoaquimRodríguez Chiaradia, Diego AgustínBalcells, EvaPronòstic mèdicFibrosi pulmonarPrognosisBackground Different clinical predictors of physical activity (PA) have been described in idiopathic pulmonary fibrosis (IPF), but studies are lacking evaluating the potential role of muscle strength and anxiety and depression symptoms in PA limitation. Moreover, little is known about the impact of changes in PA in the course of the disease. The aim of the present study was to investigate the relationship between baseline PA and a wide range of variables in IPF, to assess its longitudinal changes at 12 months and its impact on progression free-survival. Methods PA was assessed by accelerometer and physiological, clinical, psychological factors and health-related quality of life were evaluated in subjects with IPF at baseline and at 12 month follow-up. Predictors of PA were determined at baseline, evolution of PA parameters was described and the prognostic role of PA evolution was also established. Results Forty participants with IPF were included and 22 completed the follow-up. At baseline, subjects performed 5765 (3442) daily steps and spent 64 (44) minutes/day in moderate to vigorous PA. Multivariate regression models showed that at baseline, a lower six-minute walked distance, lower quadriceps strength (QMVC), and a higher depression score in the Hospital Anxiety and Depression scale were associated to lower daily step number. In addition, being in (Gender-Age-Physiology) GAP III stage, having a BMI >= 25 kg/m(2) and lower QMVC or maximum inspiratory pressure were factors associated with sedentary behaviour. Adjusted for age, gender and forced vital capacity (FVC) (%pred.) a lower progression-free survival was evidenced in those subjects that decreased PA compared to those that maintained, or even increased it, at 12 months [HR 12.1 (95% CI, 1.9-78.8); p = 0.009]. Conclusion Among a wide range of variables, muscle strength and depression symptoms have a predominant role in PA in IPF patients. Daily PA behaviour and its evolution should be considered in IPF clinical assessment and as a potential complementary indicator of disease prognosis.Springer Science and Business Media LLC2022202220222022info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion9 p.application/pdfapplication/pdfhttps://hdl.handle.net/2445/189562Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésReproducció del document publicat a: https://doi.org/10.1186/s12890-022-02134-4BMC Pulmonary Medicine, 2022, vol. 22, núm. 1https://doi.org/10.1186/s12890-022-02134-4cc by (c) Badenes Bonet, Diana et al., 2022http://creativecommons.org/licenses/by/3.0/es/info:eu-repo/semantics/openAccessoai:recercat.cat:2445/1895622026-05-29T05:05:01Z
dc.title.none.fl_str_mv Predictors and changes of physical activity in idiopathic pulmonary fibrosis
title Predictors and changes of physical activity in idiopathic pulmonary fibrosis
spellingShingle Predictors and changes of physical activity in idiopathic pulmonary fibrosis
Badenes Bonet, Diana
Pronòstic mèdic
Fibrosi pulmonar
Prognosis
title_short Predictors and changes of physical activity in idiopathic pulmonary fibrosis
title_full Predictors and changes of physical activity in idiopathic pulmonary fibrosis
title_fullStr Predictors and changes of physical activity in idiopathic pulmonary fibrosis
title_full_unstemmed Predictors and changes of physical activity in idiopathic pulmonary fibrosis
title_sort Predictors and changes of physical activity in idiopathic pulmonary fibrosis
dc.creator.none.fl_str_mv Badenes Bonet, Diana
Rodó Pin, Anna
Castillo Villegas, Diego
Vicens Zygmunt, Vanesa
Bermudo, Guadalupe
Hernández González, Fernanda
Portillo, Karina
Martínez Llorens, Juana
Chalela, Roberto
Caguana, Oswaldo
Sellarés Torres, Jacobo
Molina Molina, María
Duran, Xavier, 1959-
Gea Guiral, Joaquim
Rodríguez Chiaradia, Diego Agustín
Balcells, Eva
author Badenes Bonet, Diana
author_facet Badenes Bonet, Diana
Rodó Pin, Anna
Castillo Villegas, Diego
Vicens Zygmunt, Vanesa
Bermudo, Guadalupe
Hernández González, Fernanda
Portillo, Karina
Martínez Llorens, Juana
Chalela, Roberto
Caguana, Oswaldo
Sellarés Torres, Jacobo
Molina Molina, María
Duran, Xavier, 1959-
Gea Guiral, Joaquim
Rodríguez Chiaradia, Diego Agustín
Balcells, Eva
author_role author
author2 Rodó Pin, Anna
Castillo Villegas, Diego
Vicens Zygmunt, Vanesa
Bermudo, Guadalupe
Hernández González, Fernanda
Portillo, Karina
Martínez Llorens, Juana
Chalela, Roberto
Caguana, Oswaldo
Sellarés Torres, Jacobo
Molina Molina, María
Duran, Xavier, 1959-
Gea Guiral, Joaquim
Rodríguez Chiaradia, Diego Agustín
Balcells, Eva
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Pronòstic mèdic
Fibrosi pulmonar
Prognosis
topic Pronòstic mèdic
Fibrosi pulmonar
Prognosis
description Background Different clinical predictors of physical activity (PA) have been described in idiopathic pulmonary fibrosis (IPF), but studies are lacking evaluating the potential role of muscle strength and anxiety and depression symptoms in PA limitation. Moreover, little is known about the impact of changes in PA in the course of the disease. The aim of the present study was to investigate the relationship between baseline PA and a wide range of variables in IPF, to assess its longitudinal changes at 12 months and its impact on progression free-survival. Methods PA was assessed by accelerometer and physiological, clinical, psychological factors and health-related quality of life were evaluated in subjects with IPF at baseline and at 12 month follow-up. Predictors of PA were determined at baseline, evolution of PA parameters was described and the prognostic role of PA evolution was also established. Results Forty participants with IPF were included and 22 completed the follow-up. At baseline, subjects performed 5765 (3442) daily steps and spent 64 (44) minutes/day in moderate to vigorous PA. Multivariate regression models showed that at baseline, a lower six-minute walked distance, lower quadriceps strength (QMVC), and a higher depression score in the Hospital Anxiety and Depression scale were associated to lower daily step number. In addition, being in (Gender-Age-Physiology) GAP III stage, having a BMI >= 25 kg/m(2) and lower QMVC or maximum inspiratory pressure were factors associated with sedentary behaviour. Adjusted for age, gender and forced vital capacity (FVC) (%pred.) a lower progression-free survival was evidenced in those subjects that decreased PA compared to those that maintained, or even increased it, at 12 months [HR 12.1 (95% CI, 1.9-78.8); p = 0.009]. Conclusion Among a wide range of variables, muscle strength and depression symptoms have a predominant role in PA in IPF patients. Daily PA behaviour and its evolution should be considered in IPF clinical assessment and as a potential complementary indicator of disease prognosis.
publishDate 2022
dc.date.none.fl_str_mv 2022
2022
2022
2022
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/189562
url https://hdl.handle.net/2445/189562
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.1186/s12890-022-02134-4
BMC Pulmonary Medicine, 2022, vol. 22, núm. 1
https://doi.org/10.1186/s12890-022-02134-4
dc.rights.none.fl_str_mv cc by (c) Badenes Bonet, Diana et al., 2022
http://creativecommons.org/licenses/by/3.0/es/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc by (c) Badenes Bonet, Diana et al., 2022
http://creativecommons.org/licenses/by/3.0/es/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 9 p.
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Springer Science and Business Media LLC
publisher.none.fl_str_mv Springer Science and Business Media LLC
dc.source.none.fl_str_mv Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,811543

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