Epidermal mineralocorticoid receptor plays beneficial and adverse effects in skin and mediates glucocorticoid responses

10 páginas, 6 figuras. Contiene material suplementario

Detalles Bibliográficos
Autores: Boix, Julia, Sevilla, Lisa M., Sáez, Zara, Carceller, Elena, Pérez, Paloma
Tipo de recurso: artículo
Estado:Versión aceptada para publicación
Fecha de publicación:2016
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/149414
Acceso en línea:http://hdl.handle.net/10261/149414
Access Level:acceso abierto
Palabra clave:Glucocorticoids
Mineralocorticoid receptor
Epidermal knock-out
Inflammation
Skin damage
Wounding
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spelling Epidermal mineralocorticoid receptor plays beneficial and adverse effects in skin and mediates glucocorticoid responsesBoix, JuliaSevilla, Lisa M.Sáez, ZaraCarceller, ElenaPérez, PalomaGlucocorticoidsMineralocorticoid receptorEpidermal knock-outInflammationSkin damageWounding10 páginas, 6 figuras. Contiene material suplementarioGlucocorticoids (GCs) regulate skin homeostasis and combat cutaneous inflammatory diseases; however, adverse effects of chronic GC treatments limit their therapeutic use. GCs bind and activate the GC receptor and the mineralocorticoid receptor (MR), transcription factors that recognize identical hormone responsive elements. Whether epidermal MR mediates beneficial or deleterious GC effects is of great interest for improving GC-based skin therapies. MR epidermal knockout mice exhibited increased keratinocyte proliferation and differentiation and showed resistance to GC-induced epidermal thinning. However, crucially, loss of epidermal MR rendered mice more sensitive to inflammatory stimuli and skin damage. MR epidermal knockout mice showed increased susceptibility to phorbol 12-myristate 13-acetate-induced inflammation with higher cytokine induction. Likewise, cultured MR epidermal knockout keratinocytes had increased phorbol 12-myristate 13-acetate-induced NF-κB activation, highlighting an anti-inflammatory function for MR. GC-induced transcription was reduced in MR epidermal knockout keratinocytes, at least partially due to decreased recruitment of GC receptor to hormone responsive element-containing sequences. Our results support a role for epidermal MR in adult skin homeostasis and demonstrate nonredundant roles for MR and GC receptor in mediating GC actions.This work was supported by grant SAF2011-28115 and SAF2014-59474-R (MINECO, Spanish Government). JB and EC are recipients of FPI (BES-2012-0578) and FPU (AP201-06094) fellowships of MINECO, respectively. We thank COST ADMIRE BM- 1301 and NURCAMEIN (SAF2015-71878-REDT) for support for dissemination.Peer reviewedElsevierMinisterio de Economía y Competitividad (España)European CommissionConsejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]201720172016info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Postprintinfo:eu-repo/semantics/acceptedVersionhttp://hdl.handle.net/10261/149414reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Inglés#PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE#info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/SAF2011-28115info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/SAF2014-59474-Rinfo:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/SAF2015-71878-REDThttp://dx.doi.org/10.1016/j.jid.2016.07.018Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/1494142026-05-22T06:33:51Z
dc.title.none.fl_str_mv Epidermal mineralocorticoid receptor plays beneficial and adverse effects in skin and mediates glucocorticoid responses
title Epidermal mineralocorticoid receptor plays beneficial and adverse effects in skin and mediates glucocorticoid responses
spellingShingle Epidermal mineralocorticoid receptor plays beneficial and adverse effects in skin and mediates glucocorticoid responses
Boix, Julia
Glucocorticoids
Mineralocorticoid receptor
Epidermal knock-out
Inflammation
Skin damage
Wounding
title_short Epidermal mineralocorticoid receptor plays beneficial and adverse effects in skin and mediates glucocorticoid responses
title_full Epidermal mineralocorticoid receptor plays beneficial and adverse effects in skin and mediates glucocorticoid responses
title_fullStr Epidermal mineralocorticoid receptor plays beneficial and adverse effects in skin and mediates glucocorticoid responses
title_full_unstemmed Epidermal mineralocorticoid receptor plays beneficial and adverse effects in skin and mediates glucocorticoid responses
title_sort Epidermal mineralocorticoid receptor plays beneficial and adverse effects in skin and mediates glucocorticoid responses
dc.creator.none.fl_str_mv Boix, Julia
Sevilla, Lisa M.
Sáez, Zara
Carceller, Elena
Pérez, Paloma
author Boix, Julia
author_facet Boix, Julia
Sevilla, Lisa M.
Sáez, Zara
Carceller, Elena
Pérez, Paloma
author_role author
author2 Sevilla, Lisa M.
Sáez, Zara
Carceller, Elena
Pérez, Paloma
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Ministerio de Economía y Competitividad (España)
European Commission
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Glucocorticoids
Mineralocorticoid receptor
Epidermal knock-out
Inflammation
Skin damage
Wounding
topic Glucocorticoids
Mineralocorticoid receptor
Epidermal knock-out
Inflammation
Skin damage
Wounding
description 10 páginas, 6 figuras. Contiene material suplementario
publishDate 2016
dc.date.none.fl_str_mv 2016
2017
2017
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Postprint
info:eu-repo/semantics/acceptedVersion
format article
status_str acceptedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/149414
url http://hdl.handle.net/10261/149414
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv #PLACEHOLDER_PARENT_METADATA_VALUE#
#PLACEHOLDER_PARENT_METADATA_VALUE#
#PLACEHOLDER_PARENT_METADATA_VALUE#
info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/SAF2011-28115
info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/SAF2014-59474-R
info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/SAF2015-71878-REDT
http://dx.doi.org/10.1016/j.jid.2016.07.018
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
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