The neutrophil to lymphocyte ratio associates with markers of Alzheimer's disease pathology in cognitively unimpaired elderly people

Background An elevated neutrophil-lymphocyte ratio (NLR) in blood has been associated with Alzheimer's disease (AD). However, an elevated NLR has also been implicated in many other conditions that are risk factors for AD, prompting investigation into whether the NLR is directly linked with AD p...

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Autores: Jacobs, T, Jacobson, SR, Fortea, J, Berger, JS, Vedvyas, A, Marsh, K, He, TS, Gutierrez-Jimenez, E, Fillmore, NR, Gonzalez, M, Figueredo, L, Gaggi, NL, Plaska, CR, Pomara, N, Blessing, E, Betensky, R, Rusinek, H, Zetterberg, H, Blennow, K, Glodzik, L, Wisniweski, TM, de Leon, MJ, Osorio, RS, Ramos-Cejudo, J
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2024
País:España
Institución:Institut d’Investigació Biomèdica Sant Pau (IIB Sant Pau)
Repositorio:r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
OAI Identifier:oai:iibsantpau.fundanetsuite.com:p18111
Acceso en línea:https://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=18111
http://ddd.uab.cat/record/306311
Access Level:acceso abierto
Palabra clave:NLR
Neutrophil to lymphocyte ratio
CSF
T-tau
P-tau
Amyloid-beta
Alzheimer's disease
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spelling The neutrophil to lymphocyte ratio associates with markers of Alzheimer's disease pathology in cognitively unimpaired elderly peopleJacobs, TJacobson, SRFortea, JBerger, JSVedvyas, AMarsh, KHe, TSGutierrez-Jimenez, EFillmore, NRGonzalez, MFigueredo, LGaggi, NLPlaska, CRPomara, NBlessing, EBetensky, RRusinek, HZetterberg, HBlennow, KGlodzik, LWisniweski, TMde Leon, MJOsorio, RSRamos-Cejudo, JNLRNeutrophil to lymphocyte ratioCSFT-tauP-tauAmyloid-betaAlzheimer's diseaseBackground An elevated neutrophil-lymphocyte ratio (NLR) in blood has been associated with Alzheimer's disease (AD). However, an elevated NLR has also been implicated in many other conditions that are risk factors for AD, prompting investigation into whether the NLR is directly linked with AD pathology or a result of underlying comorbidities. Herein, we explored the relationship between the NLR and AD biomarkers in the cerebrospinal fluid (CSF) of cognitively unimpaired (CU) subjects. Adjusting for sociodemographics, APOE4, and common comorbidities, we investigated these associations in two cohorts: the Alzheimer's Disease Neuroimaging Initiative (ADNI) and the M.J. de Leon CSF repository at NYU. Specifically, we examined associations between the NLR and cross-sectional measures of amyloid-beta 42 (A beta 42), total tau (t-tau), and phosphorylated tau(181) (p-tau), as well as the trajectories of these CSF measures obtained longitudinally. Results A total of 111 ADNI and 190 NYU participants classified as CU with available NLR, CSF, and covariate data were included. Compared to NYU, ADNI participants were older (73.79 vs. 61.53, p < 0.001), had a higher proportion of males (49.5% vs. 36.8%, p = 0.042), higher BMIs (27.94 vs. 25.79, p < 0.001), higher prevalence of hypertensive history (47.7% vs. 16.3%, p < 0.001), and a greater percentage of A beta-positivity (34.2% vs. 20.0%, p = 0.009). In the ADNI cohort, we found cross-sectional associations between the NLR and CSF A beta 42 (beta = -12.193, p = 0.021), but not t-tau or p-tau. In the NYU cohort, we found cross-sectional associations between the NLR and CSF t-tau (beta = 26.812, p = 0.019) and p-tau (beta = 3.441, p = 0.015), but not A beta 42. In the NYU cohort alone, subjects classified as A beta + (n = 38) displayed a stronger association between the NLR and t-tau (beta = 100.476, p = 0.037) compared to A beta- subjects or the non-stratified cohort. In both cohorts, the same associations observed in the cross-sectional analyses were observed after incorporating longitudinal CSF data. Conclusions We report associations between the NLR and A beta 42 in the older ADNI cohort, and between the NLR and t-tau and p-tau in the younger NYU cohort. Associations persisted after adjusting for comorbidities, suggesting a direct link between the NLR and AD. However, changes in associations between the NLR and specific AD biomarkers may occur as part of immunosenescence.BMC2024info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=18111http://ddd.uab.cat/record/306311Immunity & AgeingISSN: 17424933reponame:r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pauinstname:Institut d’Investigació Biomèdica Sant Pau (IIB Sant Pau)Inglésinfo:eu-repo/semantics/openAccessoai:iibsantpau.fundanetsuite.com:p181112026-06-14T12:41:47Z
dc.title.none.fl_str_mv The neutrophil to lymphocyte ratio associates with markers of Alzheimer's disease pathology in cognitively unimpaired elderly people
title The neutrophil to lymphocyte ratio associates with markers of Alzheimer's disease pathology in cognitively unimpaired elderly people
spellingShingle The neutrophil to lymphocyte ratio associates with markers of Alzheimer's disease pathology in cognitively unimpaired elderly people
Jacobs, T
NLR
Neutrophil to lymphocyte ratio
CSF
T-tau
P-tau
Amyloid-beta
Alzheimer's disease
title_short The neutrophil to lymphocyte ratio associates with markers of Alzheimer's disease pathology in cognitively unimpaired elderly people
title_full The neutrophil to lymphocyte ratio associates with markers of Alzheimer's disease pathology in cognitively unimpaired elderly people
title_fullStr The neutrophil to lymphocyte ratio associates with markers of Alzheimer's disease pathology in cognitively unimpaired elderly people
title_full_unstemmed The neutrophil to lymphocyte ratio associates with markers of Alzheimer's disease pathology in cognitively unimpaired elderly people
title_sort The neutrophil to lymphocyte ratio associates with markers of Alzheimer's disease pathology in cognitively unimpaired elderly people
dc.creator.none.fl_str_mv Jacobs, T
Jacobson, SR
Fortea, J
Berger, JS
Vedvyas, A
Marsh, K
He, TS
Gutierrez-Jimenez, E
Fillmore, NR
Gonzalez, M
Figueredo, L
Gaggi, NL
Plaska, CR
Pomara, N
Blessing, E
Betensky, R
Rusinek, H
Zetterberg, H
Blennow, K
Glodzik, L
Wisniweski, TM
de Leon, MJ
Osorio, RS
Ramos-Cejudo, J
author Jacobs, T
author_facet Jacobs, T
Jacobson, SR
Fortea, J
Berger, JS
Vedvyas, A
Marsh, K
He, TS
Gutierrez-Jimenez, E
Fillmore, NR
Gonzalez, M
Figueredo, L
Gaggi, NL
Plaska, CR
Pomara, N
Blessing, E
Betensky, R
Rusinek, H
Zetterberg, H
Blennow, K
Glodzik, L
Wisniweski, TM
de Leon, MJ
Osorio, RS
Ramos-Cejudo, J
author_role author
author2 Jacobson, SR
Fortea, J
Berger, JS
Vedvyas, A
Marsh, K
He, TS
Gutierrez-Jimenez, E
Fillmore, NR
Gonzalez, M
Figueredo, L
Gaggi, NL
Plaska, CR
Pomara, N
Blessing, E
Betensky, R
Rusinek, H
Zetterberg, H
Blennow, K
Glodzik, L
Wisniweski, TM
de Leon, MJ
Osorio, RS
Ramos-Cejudo, J
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv NLR
Neutrophil to lymphocyte ratio
CSF
T-tau
P-tau
Amyloid-beta
Alzheimer's disease
topic NLR
Neutrophil to lymphocyte ratio
CSF
T-tau
P-tau
Amyloid-beta
Alzheimer's disease
description Background An elevated neutrophil-lymphocyte ratio (NLR) in blood has been associated with Alzheimer's disease (AD). However, an elevated NLR has also been implicated in many other conditions that are risk factors for AD, prompting investigation into whether the NLR is directly linked with AD pathology or a result of underlying comorbidities. Herein, we explored the relationship between the NLR and AD biomarkers in the cerebrospinal fluid (CSF) of cognitively unimpaired (CU) subjects. Adjusting for sociodemographics, APOE4, and common comorbidities, we investigated these associations in two cohorts: the Alzheimer's Disease Neuroimaging Initiative (ADNI) and the M.J. de Leon CSF repository at NYU. Specifically, we examined associations between the NLR and cross-sectional measures of amyloid-beta 42 (A beta 42), total tau (t-tau), and phosphorylated tau(181) (p-tau), as well as the trajectories of these CSF measures obtained longitudinally. Results A total of 111 ADNI and 190 NYU participants classified as CU with available NLR, CSF, and covariate data were included. Compared to NYU, ADNI participants were older (73.79 vs. 61.53, p < 0.001), had a higher proportion of males (49.5% vs. 36.8%, p = 0.042), higher BMIs (27.94 vs. 25.79, p < 0.001), higher prevalence of hypertensive history (47.7% vs. 16.3%, p < 0.001), and a greater percentage of A beta-positivity (34.2% vs. 20.0%, p = 0.009). In the ADNI cohort, we found cross-sectional associations between the NLR and CSF A beta 42 (beta = -12.193, p = 0.021), but not t-tau or p-tau. In the NYU cohort, we found cross-sectional associations between the NLR and CSF t-tau (beta = 26.812, p = 0.019) and p-tau (beta = 3.441, p = 0.015), but not A beta 42. In the NYU cohort alone, subjects classified as A beta + (n = 38) displayed a stronger association between the NLR and t-tau (beta = 100.476, p = 0.037) compared to A beta- subjects or the non-stratified cohort. In both cohorts, the same associations observed in the cross-sectional analyses were observed after incorporating longitudinal CSF data. Conclusions We report associations between the NLR and A beta 42 in the older ADNI cohort, and between the NLR and t-tau and p-tau in the younger NYU cohort. Associations persisted after adjusting for comorbidities, suggesting a direct link between the NLR and AD. However, changes in associations between the NLR and specific AD biomarkers may occur as part of immunosenescence.
publishDate 2024
dc.date.none.fl_str_mv 2024
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=18111
http://ddd.uab.cat/record/306311
url https://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=18111
http://ddd.uab.cat/record/306311
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv BMC
publisher.none.fl_str_mv BMC
dc.source.none.fl_str_mv Immunity & Ageing
ISSN: 17424933
reponame:r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
instname:Institut d’Investigació Biomèdica Sant Pau (IIB Sant Pau)
instname_str Institut d’Investigació Biomèdica Sant Pau (IIB Sant Pau)
reponame_str r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
collection r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.81155

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