The effect of atypical nucleic acids structures in DNA double strand break repair: a tale of R-loops and G-quadruplexes
The fine tuning of the DNA double strand break repair pathway choice relies on different regulatory layers that respond to environmental and local cues. Among them, the presence of non-canonical nucleic acids structures seems to create challenges for the repair of nearby DNA double strand breaks. In...
| Autores: | , , |
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| Tipo de documento: | artigo |
| Estado: | Versão publicada |
| Data de publicação: | 2021 |
| País: | España |
| Recursos: | Universidad de Sevilla (US) |
| Repositório: | idUS. Depósito de Investigación de la Universidad de Sevilla |
| OAI Identifier: | oai:idus.us.es:11441/127275 |
| Acesso em linha: | https://hdl.handle.net/11441/127275 https://doi.org/10.3389/fgene.2021.742434 |
| Access Level: | Acceso aberto |
| Palavra-chave: | DNA double strand break repair DNA end resection G-quadruplex Homologous recombination (HR) R-loops |
| Resumo: | The fine tuning of the DNA double strand break repair pathway choice relies on different regulatory layers that respond to environmental and local cues. Among them, the presence of non-canonical nucleic acids structures seems to create challenges for the repair of nearby DNA double strand breaks. In this review, we focus on the recently published effects of G-quadruplexes and R-loops on DNA end resection and homologous recombination. Finally, we hypothesized a connection between those two atypical DNA structures in inhibiting the DNA end resection step of HR. |
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