Disease resistance in Atlantic salmon (Salmo salar) Coinfection of the intracellular bacterial pathogen Piscirickettsia salmonis and the sea louse Caligus rogercresseyi

Background Naturally occurring coinfections of pathogens have been reported in salmonids, but their consequences on disease resistance are unclear. We hypothesized that 1) coinfection of Caligus rogercresseyi reduces the resistance of Atlantic salmon to Piscirickettsia salmonis; and 2) coinfection r...

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Autores: Lhorente, J. P., Gallardo, José Andrés, Villanueva, Beatriz, Carabaño Luengo, María Jesús, Neira, R.
Tipo de recurso: artículo
Fecha de publicación:2014
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/294108
Acceso en línea:http://hdl.handle.net/10261/294108
Access Level:acceso abierto
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spelling Disease resistance in Atlantic salmon (Salmo salar) Coinfection of the intracellular bacterial pathogen Piscirickettsia salmonis and the sea louse Caligus rogercresseyiLhorente, J. P.Gallardo, José AndrésVillanueva, BeatrizCarabaño Luengo, María JesúsNeira, R.Background Naturally occurring coinfections of pathogens have been reported in salmonids, but their consequences on disease resistance are unclear. We hypothesized that 1) coinfection of Caligus rogercresseyi reduces the resistance of Atlantic salmon to Piscirickettsia salmonis; and 2) coinfection resistance is a heritable trait that does not correlate with resistance to a single infection. Methodology In total, 1,634 pedigreed Atlantic salmon were exposed to a single infection (SI) of P. salmonis (primary pathogen) or coinfection with C. rogercresseyi (secondary pathogen). Low and high level of coinfection were evaluated (LC = 44 copepodites per fish; HC = 88 copepodites per fish). Survival and quantitative genetic analyses were performed to determine the resistance to the single infection and coinfections. Main Findings C. rogercresseyi significantly increased the mortality in fish infected with P. salmonis (SI mortality = 251/545; LC mortality = 544/544 and HC mortality = 545/545). Heritability estimates for resistance to P. salmonis were similar and of medium magnitude in all treatments (h2 SI = 0.2360.07; h2 LC = 0.1760.08; h2 HC = 0.2460.07). A large and significant genetic correlation with regard to resistance was observed between coinfection treatments (rg LC-HC = 0.9960.01) but not between the single and coinfection treatments (rg SI-LC =20.1460.33; rg SI-HC = 0.3260.34). Conclusions/Significance C. rogercresseyi, as a secondary pathogen, reduces the resistance of Atlantic salmon to the pathogen P. salmonis. Resistance to coinfection of Piscirickettsia salmonis and Caligus rogercresseyi in Atlantic salmon is a heritable trait. The absence of a genetic correlation between resistance to a single infection and resistance to coinfection indicates that different genes control these processes. Coinfection of different pathogens and resistance to coinfection needs to be considered in future research on salmon farming, selective breeding and conservation. © 2014 Lhorente et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.Peer reviewedPublic Library of ScienceVillanueva, Beatriz [0000-0003-4645-8853]Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]202320232014info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501http://hdl.handle.net/10261/294108reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)InglésDepartamento de Mejora Genética AnimalSíinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/2941082026-05-22T06:33:51Z
dc.title.none.fl_str_mv Disease resistance in Atlantic salmon (Salmo salar) Coinfection of the intracellular bacterial pathogen Piscirickettsia salmonis and the sea louse Caligus rogercresseyi
title Disease resistance in Atlantic salmon (Salmo salar) Coinfection of the intracellular bacterial pathogen Piscirickettsia salmonis and the sea louse Caligus rogercresseyi
spellingShingle Disease resistance in Atlantic salmon (Salmo salar) Coinfection of the intracellular bacterial pathogen Piscirickettsia salmonis and the sea louse Caligus rogercresseyi
Lhorente, J. P.
title_short Disease resistance in Atlantic salmon (Salmo salar) Coinfection of the intracellular bacterial pathogen Piscirickettsia salmonis and the sea louse Caligus rogercresseyi
title_full Disease resistance in Atlantic salmon (Salmo salar) Coinfection of the intracellular bacterial pathogen Piscirickettsia salmonis and the sea louse Caligus rogercresseyi
title_fullStr Disease resistance in Atlantic salmon (Salmo salar) Coinfection of the intracellular bacterial pathogen Piscirickettsia salmonis and the sea louse Caligus rogercresseyi
title_full_unstemmed Disease resistance in Atlantic salmon (Salmo salar) Coinfection of the intracellular bacterial pathogen Piscirickettsia salmonis and the sea louse Caligus rogercresseyi
title_sort Disease resistance in Atlantic salmon (Salmo salar) Coinfection of the intracellular bacterial pathogen Piscirickettsia salmonis and the sea louse Caligus rogercresseyi
dc.creator.none.fl_str_mv Lhorente, J. P.
Gallardo, José Andrés
Villanueva, Beatriz
Carabaño Luengo, María Jesús
Neira, R.
author Lhorente, J. P.
author_facet Lhorente, J. P.
Gallardo, José Andrés
Villanueva, Beatriz
Carabaño Luengo, María Jesús
Neira, R.
author_role author
author2 Gallardo, José Andrés
Villanueva, Beatriz
Carabaño Luengo, María Jesús
Neira, R.
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Villanueva, Beatriz [0000-0003-4645-8853]
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
description Background Naturally occurring coinfections of pathogens have been reported in salmonids, but their consequences on disease resistance are unclear. We hypothesized that 1) coinfection of Caligus rogercresseyi reduces the resistance of Atlantic salmon to Piscirickettsia salmonis; and 2) coinfection resistance is a heritable trait that does not correlate with resistance to a single infection. Methodology In total, 1,634 pedigreed Atlantic salmon were exposed to a single infection (SI) of P. salmonis (primary pathogen) or coinfection with C. rogercresseyi (secondary pathogen). Low and high level of coinfection were evaluated (LC = 44 copepodites per fish; HC = 88 copepodites per fish). Survival and quantitative genetic analyses were performed to determine the resistance to the single infection and coinfections. Main Findings C. rogercresseyi significantly increased the mortality in fish infected with P. salmonis (SI mortality = 251/545; LC mortality = 544/544 and HC mortality = 545/545). Heritability estimates for resistance to P. salmonis were similar and of medium magnitude in all treatments (h2 SI = 0.2360.07; h2 LC = 0.1760.08; h2 HC = 0.2460.07). A large and significant genetic correlation with regard to resistance was observed between coinfection treatments (rg LC-HC = 0.9960.01) but not between the single and coinfection treatments (rg SI-LC =20.1460.33; rg SI-HC = 0.3260.34). Conclusions/Significance C. rogercresseyi, as a secondary pathogen, reduces the resistance of Atlantic salmon to the pathogen P. salmonis. Resistance to coinfection of Piscirickettsia salmonis and Caligus rogercresseyi in Atlantic salmon is a heritable trait. The absence of a genetic correlation between resistance to a single infection and resistance to coinfection indicates that different genes control these processes. Coinfection of different pathogens and resistance to coinfection needs to be considered in future research on salmon farming, selective breeding and conservation. © 2014 Lhorente et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
publishDate 2014
dc.date.none.fl_str_mv 2014
2023
2023
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
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dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/294108
url http://hdl.handle.net/10261/294108
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Departamento de Mejora Genética Animal
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Public Library of Science
publisher.none.fl_str_mv Public Library of Science
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
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