Shaping current European mitochondrial haplogroup frequency in response to infection: the case of SARS-CoV-2 severity

The frequency of mitochondrial DNA haplogroups (mtDNA-HG) in humans is known to be shaped by migration and repopulation. Mounting evidence indicates that mtDNA-HG are not phenotypically neutral, and selection may contribute to its distribution. Haplogroup H, the most abundant in Europe, improved sur...

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Authors: Cabrera Alarcón, José Luis, Cruz, Raquel, Rosa-Moreno, Marina, Latorre-Pellicer, Ana, Diz de Almeida, Silvia, SCOURGE cohort group, Medrano Ortega, Francisco Javier, Rodríguez Hernández, María A., Morilla Romero de la Osa, Rubén, Valido Morales, Agustín S., Enríquez, José Antonio
Format: article
Status:Published version
Publication Date:2025
Country:España
Institution:Universidad de Sevilla (US)
Repository:idUS. Depósito de Investigación de la Universidad de Sevilla
OAI Identifier:oai:idus.us.es:11441/175216
Online Access:https://hdl.handle.net/11441/175216
https://doi.org/10.1038/s42003-024-07314-y
Access Level:Open access
Keyword:Mitochondrial DNA haplogroups
Migration
Repopulation
Sepsis
SARS-CoV-2
Pandemics
Europe
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spelling Shaping current European mitochondrial haplogroup frequency in response to infection: the case of SARS-CoV-2 severityCabrera Alarcón, José LuisCruz, RaquelRosa-Moreno, MarinaLatorre-Pellicer, AnaDiz de Almeida, SilviaSCOURGE cohort groupMedrano Ortega, Francisco JavierRodríguez Hernández, María A.Morilla Romero de la Osa, RubénValido Morales, Agustín S.Enríquez, José AntonioMitochondrial DNA haplogroupsMigrationRepopulationSepsisSARS-CoV-2PandemicsEuropeThe frequency of mitochondrial DNA haplogroups (mtDNA-HG) in humans is known to be shaped by migration and repopulation. Mounting evidence indicates that mtDNA-HG are not phenotypically neutral, and selection may contribute to its distribution. Haplogroup H, the most abundant in Europe, improved survival in sepsis. Here we developed a random forest trained model for mitochondrial haplogroup calling using data procured from GWAS arrays. Our results reveal that in the context of the SARS-CoV-2 pandemic, HV branch were found to represent protective factors against the development of critical SARS-CoV-2 in an analysis of 14,349 patients. These results highlight the role of mtDNA in the response to infectious diseases and support the proposal that its expansion and population proportion has been influenced by selection through successive pandemics.Nature BriefingMedicinaBiología CelularEnfermeríaInstituto de Biomedicina de Sevilla (IBIS)2025info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/pdfhttps://hdl.handle.net/11441/175216https://doi.org/10.1038/s42003-024-07314-yreponame:idUS. Depósito de Investigación de la Universidad de Sevillainstname:Universidad de Sevilla (US)InglésCommunications Biology, 8, 33.https://www.nature.com/articles/s42003-024-07314-yinfo:eu-repo/semantics/openAccessoai:idus.us.es:11441/1752162026-06-17T12:51:07Z
dc.title.none.fl_str_mv Shaping current European mitochondrial haplogroup frequency in response to infection: the case of SARS-CoV-2 severity
title Shaping current European mitochondrial haplogroup frequency in response to infection: the case of SARS-CoV-2 severity
spellingShingle Shaping current European mitochondrial haplogroup frequency in response to infection: the case of SARS-CoV-2 severity
Cabrera Alarcón, José Luis
Mitochondrial DNA haplogroups
Migration
Repopulation
Sepsis
SARS-CoV-2
Pandemics
Europe
title_short Shaping current European mitochondrial haplogroup frequency in response to infection: the case of SARS-CoV-2 severity
title_full Shaping current European mitochondrial haplogroup frequency in response to infection: the case of SARS-CoV-2 severity
title_fullStr Shaping current European mitochondrial haplogroup frequency in response to infection: the case of SARS-CoV-2 severity
title_full_unstemmed Shaping current European mitochondrial haplogroup frequency in response to infection: the case of SARS-CoV-2 severity
title_sort Shaping current European mitochondrial haplogroup frequency in response to infection: the case of SARS-CoV-2 severity
dc.creator.none.fl_str_mv Cabrera Alarcón, José Luis
Cruz, Raquel
Rosa-Moreno, Marina
Latorre-Pellicer, Ana
Diz de Almeida, Silvia
SCOURGE cohort group
Medrano Ortega, Francisco Javier
Rodríguez Hernández, María A.
Morilla Romero de la Osa, Rubén
Valido Morales, Agustín S.
Enríquez, José Antonio
author Cabrera Alarcón, José Luis
author_facet Cabrera Alarcón, José Luis
Cruz, Raquel
Rosa-Moreno, Marina
Latorre-Pellicer, Ana
Diz de Almeida, Silvia
SCOURGE cohort group
Medrano Ortega, Francisco Javier
Rodríguez Hernández, María A.
Morilla Romero de la Osa, Rubén
Valido Morales, Agustín S.
Enríquez, José Antonio
author_role author
author2 Cruz, Raquel
Rosa-Moreno, Marina
Latorre-Pellicer, Ana
Diz de Almeida, Silvia
SCOURGE cohort group
Medrano Ortega, Francisco Javier
Rodríguez Hernández, María A.
Morilla Romero de la Osa, Rubén
Valido Morales, Agustín S.
Enríquez, José Antonio
author2_role author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Medicina
Biología Celular
Enfermería
Instituto de Biomedicina de Sevilla (IBIS)
dc.subject.none.fl_str_mv Mitochondrial DNA haplogroups
Migration
Repopulation
Sepsis
SARS-CoV-2
Pandemics
Europe
topic Mitochondrial DNA haplogroups
Migration
Repopulation
Sepsis
SARS-CoV-2
Pandemics
Europe
description The frequency of mitochondrial DNA haplogroups (mtDNA-HG) in humans is known to be shaped by migration and repopulation. Mounting evidence indicates that mtDNA-HG are not phenotypically neutral, and selection may contribute to its distribution. Haplogroup H, the most abundant in Europe, improved survival in sepsis. Here we developed a random forest trained model for mitochondrial haplogroup calling using data procured from GWAS arrays. Our results reveal that in the context of the SARS-CoV-2 pandemic, HV branch were found to represent protective factors against the development of critical SARS-CoV-2 in an analysis of 14,349 patients. These results highlight the role of mtDNA in the response to infectious diseases and support the proposal that its expansion and population proportion has been influenced by selection through successive pandemics.
publishDate 2025
dc.date.none.fl_str_mv 2025
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/11441/175216
https://doi.org/10.1038/s42003-024-07314-y
url https://hdl.handle.net/11441/175216
https://doi.org/10.1038/s42003-024-07314-y
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Communications Biology, 8, 33.
https://www.nature.com/articles/s42003-024-07314-y
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Nature Briefing
publisher.none.fl_str_mv Nature Briefing
dc.source.none.fl_str_mv reponame:idUS. Depósito de Investigación de la Universidad de Sevilla
instname:Universidad de Sevilla (US)
instname_str Universidad de Sevilla (US)
reponame_str idUS. Depósito de Investigación de la Universidad de Sevilla
collection idUS. Depósito de Investigación de la Universidad de Sevilla
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.812429

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