Synthesis and Aggregation Studies of Amino Acid-Derived Reduction-Responsive Bolaamphiphilic Compounds with Applications in Drug Delivery and DNA Condensation

Doctorat internacional

Detalles Bibliográficos
Autor: Bernal Martinez, Ana Maria
Tipo de recurso: tesis doctoral
Estado:Versión publicada
Fecha de publicación:2024
País:España
Institución:CBUC, CESCA
Repositorio:TDR. Tesis Doctorales en Red
OAI Identifier:oai:www.tdx.cat:10803/692449
Acceso en línea:http://hdl.handle.net/10803/692449
http://dx.doi.org/10.6035/14104.2024.827294
Access Level:acceso abierto
Palabra clave:Bolaamphiphile
Cationic vesicles
Nanogels
DNA condensation
Ciències
54
546
547
615
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spelling Synthesis and Aggregation Studies of Amino Acid-Derived Reduction-Responsive Bolaamphiphilic Compounds with Applications in Drug Delivery and DNA CondensationBernal Martinez, Ana MariaBolaamphiphileCationic vesiclesNanogelsDNA condensationCiències54546547615Doctorat internacionalThis thesis explores peptide-based nanocarriers, specifically cationic vesicles and nanogels formed from bolaamphiphilic molecules with a cystamine core and dipeptide groups. The first chapter discusses how these molecules form vesicles at acidic pH, capable of loading hydrophobic cargos, with sizes ranging from 140 to 500 nm. The second chapter explores nanogels that transition from vesicles at pH 4 to nanogels at pH 7, enhancing cellular uptake and improving photodynamic therapy (PDT). The third chapter introduces a dicationic diphenylalanine derivative for reversible, redox-controlled DNA condensation. This work highlights the potential of peptide-based nanomaterials in drug delivery, gene therapy, and PDT.Programa de Doctorat en CiènciesUniversitat Jaume IMiravet, JuanGalindo, FranciscoMiravet, JuanUniversitat Jaume I. Escola de Doctorat202420242024info:eu-repo/semantics/doctoralThesisinfo:eu-repo/semantics/publishedVersion193 p.application/pdfhttp://hdl.handle.net/10803/692449http://dx.doi.org/10.6035/14104.2024.827294TDX (Tesis Doctorals en Xarxa)reponame:TDR. Tesis Doctorales en Redinstname:CBUC, CESCAInglésL'accés als continguts d'aquesta tesi queda condicionat a l'acceptació de les condicions d'ús establertes per la següent llicència Creative Commons: http://creativecommons.org/licenses/by-nc-sa/4.0/http://creativecommons.org/licenses/by-nc-sa/4.0/info:eu-repo/semantics/openAccessoai:www.tdx.cat:10803/6924492026-06-14T12:46:07Z
dc.title.none.fl_str_mv Synthesis and Aggregation Studies of Amino Acid-Derived Reduction-Responsive Bolaamphiphilic Compounds with Applications in Drug Delivery and DNA Condensation
title Synthesis and Aggregation Studies of Amino Acid-Derived Reduction-Responsive Bolaamphiphilic Compounds with Applications in Drug Delivery and DNA Condensation
spellingShingle Synthesis and Aggregation Studies of Amino Acid-Derived Reduction-Responsive Bolaamphiphilic Compounds with Applications in Drug Delivery and DNA Condensation
Bernal Martinez, Ana Maria
Bolaamphiphile
Cationic vesicles
Nanogels
DNA condensation
Ciències
54
546
547
615
title_short Synthesis and Aggregation Studies of Amino Acid-Derived Reduction-Responsive Bolaamphiphilic Compounds with Applications in Drug Delivery and DNA Condensation
title_full Synthesis and Aggregation Studies of Amino Acid-Derived Reduction-Responsive Bolaamphiphilic Compounds with Applications in Drug Delivery and DNA Condensation
title_fullStr Synthesis and Aggregation Studies of Amino Acid-Derived Reduction-Responsive Bolaamphiphilic Compounds with Applications in Drug Delivery and DNA Condensation
title_full_unstemmed Synthesis and Aggregation Studies of Amino Acid-Derived Reduction-Responsive Bolaamphiphilic Compounds with Applications in Drug Delivery and DNA Condensation
title_sort Synthesis and Aggregation Studies of Amino Acid-Derived Reduction-Responsive Bolaamphiphilic Compounds with Applications in Drug Delivery and DNA Condensation
dc.creator.none.fl_str_mv Bernal Martinez, Ana Maria
author Bernal Martinez, Ana Maria
author_facet Bernal Martinez, Ana Maria
author_role author
dc.contributor.none.fl_str_mv Miravet, Juan
Galindo, Francisco
Miravet, Juan
Universitat Jaume I. Escola de Doctorat
dc.subject.none.fl_str_mv Bolaamphiphile
Cationic vesicles
Nanogels
DNA condensation
Ciències
54
546
547
615
topic Bolaamphiphile
Cationic vesicles
Nanogels
DNA condensation
Ciències
54
546
547
615
description Doctorat internacional
publishDate 2024
dc.date.none.fl_str_mv 2024
2024
2024
dc.type.none.fl_str_mv info:eu-repo/semantics/doctoralThesis
info:eu-repo/semantics/publishedVersion
format doctoralThesis
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10803/692449
http://dx.doi.org/10.6035/14104.2024.827294
url http://hdl.handle.net/10803/692449
http://dx.doi.org/10.6035/14104.2024.827294
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv http://creativecommons.org/licenses/by-nc-sa/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by-nc-sa/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 193 p.
application/pdf
dc.publisher.none.fl_str_mv Universitat Jaume I
publisher.none.fl_str_mv Universitat Jaume I
dc.source.none.fl_str_mv TDX (Tesis Doctorals en Xarxa)
reponame:TDR. Tesis Doctorales en Red
instname:CBUC, CESCA
instname_str CBUC, CESCA
reponame_str TDR. Tesis Doctorales en Red
collection TDR. Tesis Doctorales en Red
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869404840746024960
score 15,812429

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