Analysis of the R1b-DF27 haplogroup shows that a large fraction of Iberian Y-chromosome lineages originated recently in situ

Haplogroup R1b-M269 comprises most Western European Y chromosomes; of its main branches, R1b-DF27 is by far the least known, and it appears to be highly prevalent only in Iberia. We have genotyped 1072 R1b-DF27 chromosomes for six additional SNPs and 17 Y-STRs in population samples from Spain, Portu...

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Authors: Solé Morata, Neus, 1988-, Villaescusa, Patricia, García-Fernández, Carla, Font-Porterias, Neus, Illescas, María José, Valverde, Laura, Tassi, Francesca, Ghirotto, Silvia, Férec, Claude, Rouault, Karen, Jiménez-Moreno, Susana, Martínez-Jarreta, Begoña, Pinheiro, María Fátima, Zarrabeitia, María T., Carracedo, Ángel, Pancorbo, Marian M. de, Calafell i Majó, Francesc
Format: article
Status:Published version
Publication Date:2017
Country:España
Institution:Universitat Pompeu Fabra
Repository:Repositorio Digital de la UPF
OAI Identifier:oai:repositori.upf.edu:10230/32873
Online Access:http://hdl.handle.net/10230/32873
http://dx.doi.org/10.1038/s41598-017-07710-x
Access Level:Open access
Keyword:Cromosoma Y
Genòmica
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spelling Analysis of the R1b-DF27 haplogroup shows that a large fraction of Iberian Y-chromosome lineages originated recently in situSolé Morata, Neus, 1988-Villaescusa, PatriciaGarcía-Fernández, CarlaFont-Porterias, NeusIllescas, María JoséValverde, LauraTassi, FrancescaGhirotto, SilviaFérec, ClaudeRouault, KarenJiménez-Moreno, SusanaMartínez-Jarreta, BegoñaPinheiro, María FátimaZarrabeitia, María T.Carracedo, ÁngelPancorbo, Marian M. deCalafell i Majó, FrancescCromosoma YGenòmicaHaplogroup R1b-M269 comprises most Western European Y chromosomes; of its main branches, R1b-DF27 is by far the least known, and it appears to be highly prevalent only in Iberia. We have genotyped 1072 R1b-DF27 chromosomes for six additional SNPs and 17 Y-STRs in population samples from Spain, Portugal and France in order to further characterize this lineage and, in particular, to ascertain the time and place where it originated, as well as its subsequent dynamics. We found that R1b-DF27 is present in frequencies ~40% in Iberian populations and up to 70% in Basques, but it drops quickly to 6-20% in France. Overall, the age of R1b-DF27 is estimated at ~4,200 years ago, at the transition between the Neolithic and the Bronze Age, when the Y chromosome landscape of W Europe was thoroughly remodeled. In spite of its high frequency in Basques, Y-STR internal diversity of R1b-DF27 is lower there, and results in more recent age estimates; NE Iberia is the most likely place of origin of DF27. Subhaplogroup frequencies within R1b-DF27 are geographically structured, and show domains that are reminiscent of the pre-Roman Celtic/Iberian division, or of the medieval Christian kingdoms.Funding was provided by the Agencia Estatal de Investigación and Fondo Europeo de Desarollo Regional (FEDER) (grants CGL2013-44351-P, CGL2016-75389-P), by Agència de Gestió d’Ajuts Universitaris i de la Recerca (Generalitat de Catalunya) grant 2014 SGR 866, and by the Basque Government (IT-424-07). FT was supported by the ERC Advanced Grant Agreement No 295733, ‘LanGeLin’ projectNature Publishing Group201720172017info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/pdfhttp://hdl.handle.net/10230/32873http://dx.doi.org/10.1038/s41598-017-07710-xreponame:Repositorio Digital de la UPFinstname:Universitat Pompeu FabraInglésScientific Reports. 2017 Aug 4;7(1):7341info:eu-repo/grantAgreement/ES/1PE/CGL2013-44351-Pinfo:eu-repo/grantAgreement/ES/1PE/CGL2016-75389-Pinfo:eu-repo/grantAgreement/EC/FP7/295733© Nature Publishing Group. http://dx.doi.org/10.1038/s41598-017-07710-x. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were madehttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:repositori.upf.edu:10230/328732026-06-12T07:21:37Z
dc.title.none.fl_str_mv Analysis of the R1b-DF27 haplogroup shows that a large fraction of Iberian Y-chromosome lineages originated recently in situ
title Analysis of the R1b-DF27 haplogroup shows that a large fraction of Iberian Y-chromosome lineages originated recently in situ
spellingShingle Analysis of the R1b-DF27 haplogroup shows that a large fraction of Iberian Y-chromosome lineages originated recently in situ
Solé Morata, Neus, 1988-
Cromosoma Y
Genòmica
title_short Analysis of the R1b-DF27 haplogroup shows that a large fraction of Iberian Y-chromosome lineages originated recently in situ
title_full Analysis of the R1b-DF27 haplogroup shows that a large fraction of Iberian Y-chromosome lineages originated recently in situ
title_fullStr Analysis of the R1b-DF27 haplogroup shows that a large fraction of Iberian Y-chromosome lineages originated recently in situ
title_full_unstemmed Analysis of the R1b-DF27 haplogroup shows that a large fraction of Iberian Y-chromosome lineages originated recently in situ
title_sort Analysis of the R1b-DF27 haplogroup shows that a large fraction of Iberian Y-chromosome lineages originated recently in situ
dc.creator.none.fl_str_mv Solé Morata, Neus, 1988-
Villaescusa, Patricia
García-Fernández, Carla
Font-Porterias, Neus
Illescas, María José
Valverde, Laura
Tassi, Francesca
Ghirotto, Silvia
Férec, Claude
Rouault, Karen
Jiménez-Moreno, Susana
Martínez-Jarreta, Begoña
Pinheiro, María Fátima
Zarrabeitia, María T.
Carracedo, Ángel
Pancorbo, Marian M. de
Calafell i Majó, Francesc
author Solé Morata, Neus, 1988-
author_facet Solé Morata, Neus, 1988-
Villaescusa, Patricia
García-Fernández, Carla
Font-Porterias, Neus
Illescas, María José
Valverde, Laura
Tassi, Francesca
Ghirotto, Silvia
Férec, Claude
Rouault, Karen
Jiménez-Moreno, Susana
Martínez-Jarreta, Begoña
Pinheiro, María Fátima
Zarrabeitia, María T.
Carracedo, Ángel
Pancorbo, Marian M. de
Calafell i Majó, Francesc
author_role author
author2 Villaescusa, Patricia
García-Fernández, Carla
Font-Porterias, Neus
Illescas, María José
Valverde, Laura
Tassi, Francesca
Ghirotto, Silvia
Férec, Claude
Rouault, Karen
Jiménez-Moreno, Susana
Martínez-Jarreta, Begoña
Pinheiro, María Fátima
Zarrabeitia, María T.
Carracedo, Ángel
Pancorbo, Marian M. de
Calafell i Majó, Francesc
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Cromosoma Y
Genòmica
topic Cromosoma Y
Genòmica
description Haplogroup R1b-M269 comprises most Western European Y chromosomes; of its main branches, R1b-DF27 is by far the least known, and it appears to be highly prevalent only in Iberia. We have genotyped 1072 R1b-DF27 chromosomes for six additional SNPs and 17 Y-STRs in population samples from Spain, Portugal and France in order to further characterize this lineage and, in particular, to ascertain the time and place where it originated, as well as its subsequent dynamics. We found that R1b-DF27 is present in frequencies ~40% in Iberian populations and up to 70% in Basques, but it drops quickly to 6-20% in France. Overall, the age of R1b-DF27 is estimated at ~4,200 years ago, at the transition between the Neolithic and the Bronze Age, when the Y chromosome landscape of W Europe was thoroughly remodeled. In spite of its high frequency in Basques, Y-STR internal diversity of R1b-DF27 is lower there, and results in more recent age estimates; NE Iberia is the most likely place of origin of DF27. Subhaplogroup frequencies within R1b-DF27 are geographically structured, and show domains that are reminiscent of the pre-Roman Celtic/Iberian division, or of the medieval Christian kingdoms.
publishDate 2017
dc.date.none.fl_str_mv 2017
2017
2017
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10230/32873
http://dx.doi.org/10.1038/s41598-017-07710-x
url http://hdl.handle.net/10230/32873
http://dx.doi.org/10.1038/s41598-017-07710-x
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Scientific Reports. 2017 Aug 4;7(1):7341
info:eu-repo/grantAgreement/ES/1PE/CGL2013-44351-P
info:eu-repo/grantAgreement/ES/1PE/CGL2016-75389-P
info:eu-repo/grantAgreement/EC/FP7/295733
dc.rights.none.fl_str_mv http://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Nature Publishing Group
publisher.none.fl_str_mv Nature Publishing Group
dc.source.none.fl_str_mv reponame:Repositorio Digital de la UPF
instname:Universitat Pompeu Fabra
instname_str Universitat Pompeu Fabra
reponame_str Repositorio Digital de la UPF
collection Repositorio Digital de la UPF
repository.name.fl_str_mv
repository.mail.fl_str_mv
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