Neurotoxicity induced by microcystins and cylindrospermopsin: A review

Microcystins (MCs) and cylindrospermopsin (CYN) are among the most frequent toxins produced by cyanobacteria. These toxic secondary metabolites are classified as hepatotoxins and cytotoxin, respectively. Furthermore, both may present the ability to induce damage to the nervous system. In this sense,...

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Autores: Hinojosa Hidalgo, María Gracia, Gutiérrez-Praena, Daniel, Prieto Ortega, Ana Isabel, Guzmán Guillén, Remedios, Jos Gallego, Ángeles Mencía, Cameán Fernández, Ana María
Tipo de recurso: artículo
Estado:Versión aceptada para publicación
Fecha de publicación:2019
País:España
Institución:Universidad de Sevilla (US)
Repositorio:idUS. Depósito de Investigación de la Universidad de Sevilla
OAI Identifier:oai:idus.us.es:11441/128525
Acceso en línea:https://hdl.handle.net/11441/128525
https://doi.org/10.1016/j.scitotenv.2019.02.426
Access Level:acceso abierto
Palabra clave:Cyanotoxins
MCs
CYN
Nervous system
Ecotoxicology
Environmental risk
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spelling Neurotoxicity induced by microcystins and cylindrospermopsin: A reviewHinojosa Hidalgo, María GraciaGutiérrez-Praena, DanielPrieto Ortega, Ana IsabelGuzmán Guillén, RemediosJos Gallego, Ángeles MencíaCameán Fernández, Ana MaríaCyanotoxinsMCsCYNNervous systemEcotoxicologyEnvironmental riskMicrocystins (MCs) and cylindrospermopsin (CYN) are among the most frequent toxins produced by cyanobacteria. These toxic secondary metabolites are classified as hepatotoxins and cytotoxin, respectively. Furthermore, both may present the ability to induce damage to the nervous system. In this sense, there are many studies manifesting the potential of MCs to cause neurotoxicity both in vitro and in vivo, due to their probable capacity to cross the blood-brain-barrier through organic anion transporting polypeptides. Moreover, the presence of MCs has been detected in brain of several experimental models. Among the neurological effects, histopathological brain changes, deregulation of biochemical parameters in brain (production of oxidative stress and inhibition of protein phosphatases) and behavioral alterations have been described. It is noteworthy that minority variants such as MC-LF and -LW have demonstrated to exert higher neurotoxic effects compared to the most studied congener, MC-LR. By contrast, the available studies concerning CYN-neurotoxic effects are very scarce, mostly showing inflammation and apoptosis in neural murine cell lines, oxidative stress, and alteration of the acetylcholinesterase activity in vivo. However, more studies are required in order to clarify the neurotoxic potential of both toxins, as well as their possible contribution to neurodegenerative diseases.Ministerio de Economía y Competitividad (AGL2015-64558-R, MINECO/FEDER, UE)ElsevierNutrición y Bromatología, Toxicología y Medicina LegalMinisterio de Economía y Competitividad (MINECO). EspañaEuropean Commission (EC). Fondo Europeo de Desarrollo Regional (FEDER)2019info:eu-repo/semantics/articleinfo:eu-repo/semantics/acceptedVersionapplication/pdfapplication/pdfhttps://hdl.handle.net/11441/128525https://doi.org/10.1016/j.scitotenv.2019.02.426reponame:idUS. Depósito de Investigación de la Universidad de Sevillainstname:Universidad de Sevilla (US)InglésScience of The Total Environment, 668, 547-565.AGL2015-64558-Rhttps://doi.org/10.1016/j.scitotenv.2019.02.426info:eu-repo/semantics/openAccessoai:idus.us.es:11441/1285252026-06-17T12:51:07Z
dc.title.none.fl_str_mv Neurotoxicity induced by microcystins and cylindrospermopsin: A review
title Neurotoxicity induced by microcystins and cylindrospermopsin: A review
spellingShingle Neurotoxicity induced by microcystins and cylindrospermopsin: A review
Hinojosa Hidalgo, María Gracia
Cyanotoxins
MCs
CYN
Nervous system
Ecotoxicology
Environmental risk
title_short Neurotoxicity induced by microcystins and cylindrospermopsin: A review
title_full Neurotoxicity induced by microcystins and cylindrospermopsin: A review
title_fullStr Neurotoxicity induced by microcystins and cylindrospermopsin: A review
title_full_unstemmed Neurotoxicity induced by microcystins and cylindrospermopsin: A review
title_sort Neurotoxicity induced by microcystins and cylindrospermopsin: A review
dc.creator.none.fl_str_mv Hinojosa Hidalgo, María Gracia
Gutiérrez-Praena, Daniel
Prieto Ortega, Ana Isabel
Guzmán Guillén, Remedios
Jos Gallego, Ángeles Mencía
Cameán Fernández, Ana María
author Hinojosa Hidalgo, María Gracia
author_facet Hinojosa Hidalgo, María Gracia
Gutiérrez-Praena, Daniel
Prieto Ortega, Ana Isabel
Guzmán Guillén, Remedios
Jos Gallego, Ángeles Mencía
Cameán Fernández, Ana María
author_role author
author2 Gutiérrez-Praena, Daniel
Prieto Ortega, Ana Isabel
Guzmán Guillén, Remedios
Jos Gallego, Ángeles Mencía
Cameán Fernández, Ana María
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv Nutrición y Bromatología, Toxicología y Medicina Legal
Ministerio de Economía y Competitividad (MINECO). España
European Commission (EC). Fondo Europeo de Desarrollo Regional (FEDER)
dc.subject.none.fl_str_mv Cyanotoxins
MCs
CYN
Nervous system
Ecotoxicology
Environmental risk
topic Cyanotoxins
MCs
CYN
Nervous system
Ecotoxicology
Environmental risk
description Microcystins (MCs) and cylindrospermopsin (CYN) are among the most frequent toxins produced by cyanobacteria. These toxic secondary metabolites are classified as hepatotoxins and cytotoxin, respectively. Furthermore, both may present the ability to induce damage to the nervous system. In this sense, there are many studies manifesting the potential of MCs to cause neurotoxicity both in vitro and in vivo, due to their probable capacity to cross the blood-brain-barrier through organic anion transporting polypeptides. Moreover, the presence of MCs has been detected in brain of several experimental models. Among the neurological effects, histopathological brain changes, deregulation of biochemical parameters in brain (production of oxidative stress and inhibition of protein phosphatases) and behavioral alterations have been described. It is noteworthy that minority variants such as MC-LF and -LW have demonstrated to exert higher neurotoxic effects compared to the most studied congener, MC-LR. By contrast, the available studies concerning CYN-neurotoxic effects are very scarce, mostly showing inflammation and apoptosis in neural murine cell lines, oxidative stress, and alteration of the acetylcholinesterase activity in vivo. However, more studies are required in order to clarify the neurotoxic potential of both toxins, as well as their possible contribution to neurodegenerative diseases.
publishDate 2019
dc.date.none.fl_str_mv 2019
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/acceptedVersion
format article
status_str acceptedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/11441/128525
https://doi.org/10.1016/j.scitotenv.2019.02.426
url https://hdl.handle.net/11441/128525
https://doi.org/10.1016/j.scitotenv.2019.02.426
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Science of The Total Environment, 668, 547-565.
AGL2015-64558-R
https://doi.org/10.1016/j.scitotenv.2019.02.426
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:idUS. Depósito de Investigación de la Universidad de Sevilla
instname:Universidad de Sevilla (US)
instname_str Universidad de Sevilla (US)
reponame_str idUS. Depósito de Investigación de la Universidad de Sevilla
collection idUS. Depósito de Investigación de la Universidad de Sevilla
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