Incidence of Tuberculosis Among Young Children in Rural Mozambique

BACKGROUND: Tuberculosis (TB) contributes significantly to child morbidity and mortality. This study aimed to estimate the minimum community-based incidence rate of TB among children <3 years of age in Southern Mozambique. METHODS: Between October 2011 and October 2012, in the Manhica District He...

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Autores: López Varela, Elisa, Augusto, Orvalho, Gondo, Kizito, García-Basteiro, Alberto L., Fraile, Oscar, Ira, Tasmiya, Ribo Aristizabal, Jose Luis, Bulo, Helder, Muñoz Gutiérrez, José, Aponte, John J., Macete, Eusebio Víctor, Sacarlal, Jahit, Alonso, Pedro
Tipo de recurso: artículo
Estado:Versión aceptada para publicación
Fecha de publicación:2015
País:España
Institución:Universidad de Barcelona
Repositorio:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/99588
Acceso en línea:https://hdl.handle.net/2445/99588
Access Level:acceso abierto
Palabra clave:Tuberculosi
Infants
Moçambic
Tuberculosis
Children
Mozambique
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spelling Incidence of Tuberculosis Among Young Children in Rural MozambiqueLópez Varela, ElisaAugusto, OrvalhoGondo, KizitoGarcía-Basteiro, Alberto L.Fraile, OscarIra, TasmiyaRibo Aristizabal, Jose LuisBulo, HelderMuñoz Gutiérrez, JoséAponte, John J.Macete, Eusebio VíctorSacarlal, JahitAlonso, PedroTuberculosiInfantsMoçambicTuberculosisChildrenMozambiqueBACKGROUND: Tuberculosis (TB) contributes significantly to child morbidity and mortality. This study aimed to estimate the minimum community-based incidence rate of TB among children <3 years of age in Southern Mozambique. METHODS: Between October 2011 and October 2012, in the Manhica District Health and Demographic Surveillance System, we enrolled prospectively all presumptive TB cases younger than 3 years of age through passive and active case finding. Participants included all children who were either symptomatic or were close contacts of a notified adult smear-positive pulmonary TB. Children were clinically evaluated at baseline and follow-up visits. Investigation for TB disease included chest radiography, HIV and tuberculin skin testing as well as gastric aspirate and induced sputum sampling, which were processed for smear, culture and mycobacterial molecular identification. RESULTS: During the study period, 13,764 children <3 years contributed to a total of 9575 person-year. Out of the 789 presumptive TB cases enrolled, 13 had TB culture confirmation and 32 were probable TB cases. The minimum community-based incidence rate of TB (confirmed plus probable cases) was 470 of 100,000 person-year (95% confidence interval: 343-629 of 100,000). HIV co-infection was present in 44% of the TB cases. CONCLUSION: These data highlight the huge burden of pediatric TB. This study provides one of the first prospective population-based incidence data of childhood tuberculosis and adds valuable information to the global effort of producing better estimates, a critical step to inform public health policy.Wolters Kluwer Health2015info:eu-repo/semantics/articleinfo:eu-repo/semantics/acceptedVersionapplication/pdfhttps://hdl.handle.net/2445/99588Articles publicats en revistes (ISGlobal)reponame:Dipòsit Digital de la UBinstname:Universidad de BarcelonaInglésVersió postprint del document publicat a: http://dx.doi.org/10.1097/INF.0000000000000710The Pediatric Infectious Disease Journal, 2015, vol. 34, num. 7, p. 686-692http://dx.doi.org/10.1097/INF.0000000000000710(c) Wolters Kluwer Health, 2015info:eu-repo/semantics/openAccessoai:diposit.ub.edu:2445/995882026-05-27T06:46:51Z
dc.title.none.fl_str_mv Incidence of Tuberculosis Among Young Children in Rural Mozambique
title Incidence of Tuberculosis Among Young Children in Rural Mozambique
spellingShingle Incidence of Tuberculosis Among Young Children in Rural Mozambique
López Varela, Elisa
Tuberculosi
Infants
Moçambic
Tuberculosis
Children
Mozambique
title_short Incidence of Tuberculosis Among Young Children in Rural Mozambique
title_full Incidence of Tuberculosis Among Young Children in Rural Mozambique
title_fullStr Incidence of Tuberculosis Among Young Children in Rural Mozambique
title_full_unstemmed Incidence of Tuberculosis Among Young Children in Rural Mozambique
title_sort Incidence of Tuberculosis Among Young Children in Rural Mozambique
dc.creator.none.fl_str_mv López Varela, Elisa
Augusto, Orvalho
Gondo, Kizito
García-Basteiro, Alberto L.
Fraile, Oscar
Ira, Tasmiya
Ribo Aristizabal, Jose Luis
Bulo, Helder
Muñoz Gutiérrez, José
Aponte, John J.
Macete, Eusebio Víctor
Sacarlal, Jahit
Alonso, Pedro
author López Varela, Elisa
author_facet López Varela, Elisa
Augusto, Orvalho
Gondo, Kizito
García-Basteiro, Alberto L.
Fraile, Oscar
Ira, Tasmiya
Ribo Aristizabal, Jose Luis
Bulo, Helder
Muñoz Gutiérrez, José
Aponte, John J.
Macete, Eusebio Víctor
Sacarlal, Jahit
Alonso, Pedro
author_role author
author2 Augusto, Orvalho
Gondo, Kizito
García-Basteiro, Alberto L.
Fraile, Oscar
Ira, Tasmiya
Ribo Aristizabal, Jose Luis
Bulo, Helder
Muñoz Gutiérrez, José
Aponte, John J.
Macete, Eusebio Víctor
Sacarlal, Jahit
Alonso, Pedro
author2_role author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Tuberculosi
Infants
Moçambic
Tuberculosis
Children
Mozambique
topic Tuberculosi
Infants
Moçambic
Tuberculosis
Children
Mozambique
description BACKGROUND: Tuberculosis (TB) contributes significantly to child morbidity and mortality. This study aimed to estimate the minimum community-based incidence rate of TB among children <3 years of age in Southern Mozambique. METHODS: Between October 2011 and October 2012, in the Manhica District Health and Demographic Surveillance System, we enrolled prospectively all presumptive TB cases younger than 3 years of age through passive and active case finding. Participants included all children who were either symptomatic or were close contacts of a notified adult smear-positive pulmonary TB. Children were clinically evaluated at baseline and follow-up visits. Investigation for TB disease included chest radiography, HIV and tuberculin skin testing as well as gastric aspirate and induced sputum sampling, which were processed for smear, culture and mycobacterial molecular identification. RESULTS: During the study period, 13,764 children <3 years contributed to a total of 9575 person-year. Out of the 789 presumptive TB cases enrolled, 13 had TB culture confirmation and 32 were probable TB cases. The minimum community-based incidence rate of TB (confirmed plus probable cases) was 470 of 100,000 person-year (95% confidence interval: 343-629 of 100,000). HIV co-infection was present in 44% of the TB cases. CONCLUSION: These data highlight the huge burden of pediatric TB. This study provides one of the first prospective population-based incidence data of childhood tuberculosis and adds valuable information to the global effort of producing better estimates, a critical step to inform public health policy.
publishDate 2015
dc.date.none.fl_str_mv 2015
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/acceptedVersion
format article
status_str acceptedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/99588
url https://hdl.handle.net/2445/99588
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Versió postprint del document publicat a: http://dx.doi.org/10.1097/INF.0000000000000710
The Pediatric Infectious Disease Journal, 2015, vol. 34, num. 7, p. 686-692
http://dx.doi.org/10.1097/INF.0000000000000710
dc.rights.none.fl_str_mv (c) Wolters Kluwer Health, 2015
info:eu-repo/semantics/openAccess
rights_invalid_str_mv (c) Wolters Kluwer Health, 2015
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Wolters Kluwer Health
publisher.none.fl_str_mv Wolters Kluwer Health
dc.source.none.fl_str_mv Articles publicats en revistes (ISGlobal)
reponame:Dipòsit Digital de la UB
instname:Universidad de Barcelona
instname_str Universidad de Barcelona
reponame_str Dipòsit Digital de la UB
collection Dipòsit Digital de la UB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,300724

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