Evaluation of Different Benzimidazole Formulations Against Sheep Naturally Infected with Fasciola hepatica and Anthelmintic Resistance Analysis

This article belongs to the Section Veterinary Microbiology, Parasitology and Immunology.

Detalles Bibliográficos
Autores: González Del Palacio, Laura, Denwood, Matthew James, Valderas García, Elora, Castilla Gómez de Agüero, Verónica, Balaña-Fouce, Rafael, Martínez-Valladares, María
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2026
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/421515
Acceso en línea:http://hdl.handle.net/10261/421515
Access Level:acceso abierto
Palabra clave:Sheep
Fasciola hepatica
Anthelmintic resistance
Benzimidazoles
Faecal egg count reduction test
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dc.title.none.fl_str_mv Evaluation of Different Benzimidazole Formulations Against Sheep Naturally Infected with Fasciola hepatica and Anthelmintic Resistance Analysis
title Evaluation of Different Benzimidazole Formulations Against Sheep Naturally Infected with Fasciola hepatica and Anthelmintic Resistance Analysis
spellingShingle Evaluation of Different Benzimidazole Formulations Against Sheep Naturally Infected with Fasciola hepatica and Anthelmintic Resistance Analysis
González Del Palacio, Laura
Sheep
Fasciola hepatica
Anthelmintic resistance
Benzimidazoles
Faecal egg count reduction test
title_short Evaluation of Different Benzimidazole Formulations Against Sheep Naturally Infected with Fasciola hepatica and Anthelmintic Resistance Analysis
title_full Evaluation of Different Benzimidazole Formulations Against Sheep Naturally Infected with Fasciola hepatica and Anthelmintic Resistance Analysis
title_fullStr Evaluation of Different Benzimidazole Formulations Against Sheep Naturally Infected with Fasciola hepatica and Anthelmintic Resistance Analysis
title_full_unstemmed Evaluation of Different Benzimidazole Formulations Against Sheep Naturally Infected with Fasciola hepatica and Anthelmintic Resistance Analysis
title_sort Evaluation of Different Benzimidazole Formulations Against Sheep Naturally Infected with Fasciola hepatica and Anthelmintic Resistance Analysis
dc.creator.none.fl_str_mv González Del Palacio, Laura
Denwood, Matthew James
Valderas García, Elora
Castilla Gómez de Agüero, Verónica
Balaña-Fouce, Rafael
Martínez-Valladares, María
author González Del Palacio, Laura
author_facet González Del Palacio, Laura
Denwood, Matthew James
Valderas García, Elora
Castilla Gómez de Agüero, Verónica
Balaña-Fouce, Rafael
Martínez-Valladares, María
author_role author
author2 Denwood, Matthew James
Valderas García, Elora
Castilla Gómez de Agüero, Verónica
Balaña-Fouce, Rafael
Martínez-Valladares, María
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv Agencia Estatal de Investigación (España)
Ministerio de Ciencia e Innovación (España)
European Commission
Junta de Castilla y León
Ministerio para la Transformación Digital y de la Función Pública (España)
González Del Palacio, Laura [0000-0002-6396-120X]
Valderas García, Elora [0000-0002-9970-896X]
Castilla Gómez de Agüero, Verónica [0000-0002-6797-0170]
Martínez-Valladares, María [0000-0002-3723-1895]
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Sheep
Fasciola hepatica
Anthelmintic resistance
Benzimidazoles
Faecal egg count reduction test
topic Sheep
Fasciola hepatica
Anthelmintic resistance
Benzimidazoles
Faecal egg count reduction test
description This article belongs to the Section Veterinary Microbiology, Parasitology and Immunology.
publishDate 2026
dc.date.none.fl_str_mv 2026
2026
2026
2026
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/421515
url http://hdl.handle.net/10261/421515
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv #PLACEHOLDER_PARENT_METADATA_VALUE#
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info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PID2020-119035RB-I00
info:eu-repo/grantAgreement/EC/HE/101134842
The underlying dataset has been published as supplementary material of the article in the publisher platform at DOI https://doi.org/10.3390/vetsci13020205
https://doi.org/10.3390/vetsci13020205
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute
publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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spelling Evaluation of Different Benzimidazole Formulations Against Sheep Naturally Infected with Fasciola hepatica and Anthelmintic Resistance AnalysisGonzález Del Palacio, LauraDenwood, Matthew JamesValderas García, EloraCastilla Gómez de Agüero, VerónicaBalaña-Fouce, RafaelMartínez-Valladares, MaríaSheepFasciola hepaticaAnthelmintic resistanceBenzimidazolesFaecal egg count reduction testThis article belongs to the Section Veterinary Microbiology, Parasitology and Immunology.[Simple Summary] Fasciola infection is now a widely known parasitic disease that affects animals and humans, causing significant losses in livestock production worldwide. Its control depends mainly on a few antiparasitic drugs, such as albendazole and triclabendazole. The aim of this study was to evaluate the efficacy of these drugs in a flock of sheep in northwestern Spain infected with the species Fasciola hepatica, while also testing other drugs from the same family as an alternative to these treatments and comparing the results using different analysis methods. Thanks to this comparison, which was carried out using a technique that counts the eggs eliminated in the animals’ faeces at different times, it was possible to demonstrate that resistance to antiparasitic drugs is a growing problem in the treatment of fasciolosis, as well as the urgent need to standardize the methods currently used to detect such resistance.[Abstract] Fasciola infection, which is widely distributed and has a major impact on livestock production, is emerging as a significant zoonotic parasitic disease affecting both human and animal health worldwide. The main control strategy currently relies on a limited number of anthelmintic drugs, especially benzimidazoles such as albendazole and triclabendazole. The aim of this study was to evaluate the efficacy of albendazole and triclabendazole in a sheep flock in northwestern Spain naturally infected with F. hepatica and to test fenbendazole and oxfendazole as alternative formulations. For this purpose, a faecal egg count reduction test (FECRT) was conducted applying various statistical methods based on the guidelines used for gastrointestinal nematodes. This study represents the first application of the new classification framework for F. hepatica, emphasizing the urgent need for standardized resistance detection protocols for this parasite and underlining the growing challenge of anthelmintic resistance in the treatment of fasciolosis.This study was funded by the “Agencia Estatal de Investigación, Ministerio de Ciencia e Innovación”, which is responsible for the funding, evaluation, awarding and monitoring of scientific and technical research activities in Spain (Reference funding number: MCIN/AEI/PID2020-119035RB-I00). The SPARC thematic network (www.wormsparc.com) is funded by the European Union (Horizon Europe, project number 101134842). This study is based upon work from COST Action ENVIRANT (CA23154, Environmental impact of anthelmintics in livestock and alternatives to minimize their use) supported by COST (European Cooperation in Science and Technology). GdPL is a beneficiary of the Junta de Castilla y León (JCyL) (LE096-20), support funded by MCIN/AEI/10.13039/501100011033 and by “FSE invests in your future”. We thank the European Social Fund Plus, Operational Programme of Castilla y León, and the Junta de Castilla y León, through the Consejería de Educación. EVG was hired under the Generation D initiative, promoted by Red.es, an organisation attached to the Ministry for Digital Transformation and the Civil Service, for the attraction and retention of talent through grants and training contracts, financed by the Recovery, Transformation and Resilience Plan through the European Union’s Next Generation funds.Peer reviewedMultidisciplinary Digital Publishing InstituteAgencia Estatal de Investigación (España)Ministerio de Ciencia e Innovación (España)European CommissionJunta de Castilla y LeónMinisterio para la Transformación Digital y de la Función Pública (España)González Del Palacio, Laura [0000-0002-6396-120X]Valderas García, Elora [0000-0002-9970-896X]Castilla Gómez de Agüero, Verónica [0000-0002-6797-0170]Martínez-Valladares, María [0000-0002-3723-1895]Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]2026202620262026info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionapplication/pdfhttp://hdl.handle.net/10261/421515reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Inglés#PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE#info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PID2020-119035RB-I00info:eu-repo/grantAgreement/EC/HE/101134842The underlying dataset has been published as supplementary material of the article in the publisher platform at DOI https://doi.org/10.3390/vetsci13020205https://doi.org/10.3390/vetsci13020205Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/4215152026-05-22T06:33:51Z
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