Breaking barriers in electrochemical biosensing using bioinspired peptide and phage probes

Electrochemical biosensing continues to advance tirelessly, overcoming barriers that have kept it from leaving research laboratories for many years. Among them, its compromised performance in complex biological matrices due to fouling or receptor stability issues, the limitations in determining toxi...

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Detalhes bibliográficos
Autores: Campuzano Ruiz, Susana, Pedrero Muñoz, María, Barderas Manchado, Rodrigo, Pingarrón Carrazón, José Manuel
Tipo de documento: artigo
Data de publicação:2024
País:España
Recursos:Universidad Complutense de Madrid (UCM)
Repositório:Docta Complutense
Idioma:inglês
OAI Identifier:oai:docta.ucm.es:20.500.14352/123871
Acesso em linha:https://hdl.handle.net/20.500.14352/123871
Access Level:Acceso aberto
Palavra-chave:543
Electrochemical biosensing
Peptides
Phage probes
Phage display
Mimotopes
Ciencias
23 Química
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spelling Breaking barriers in electrochemical biosensing using bioinspired peptide and phage probesCampuzano Ruiz, SusanaPedrero Muñoz, MaríaBarderas Manchado, RodrigoPingarrón Carrazón, José Manuel543Electrochemical biosensingPeptidesPhage probesPhage displayMimotopesCiencias23 QuímicaElectrochemical biosensing continues to advance tirelessly, overcoming barriers that have kept it from leaving research laboratories for many years. Among them, its compromised performance in complex biological matrices due to fouling or receptor stability issues, the limitations in determining toxic and small analytes, and its use, conditioned to the commercial availability of commercial receptors and the exploration of natural molecular interactions, deserved to be highlighted. To address these challenges, in addition to the intrinsic properties of electrochemical biosensing, its coupling with biomimetic materials has played a fundamental role, among which bioinspired phage and peptide probes stand out. The versatility in design and employment of these probes has opened an unimaginable plethora of possibilities for electrochemical biosensing, improving their performance far beyond the development of highly sensitive and selective devices. The state of the art offers robust electroanalytical biotools, capable of operating in complex samples and with exciting opportunities to discover and determine targets regardless of their toxicity and size, the commercial availability of bioreceptors, and prior knowledge of molecular interactions. With all this in mind, this review offers a panoramic, novel, and updated vision of both the tremendous advances and opportunities offered by the combination of electrochemical biosensors with bioinspired phage and peptide probes and the challenges and research efforts that are envisioned in the immediate future.SpringerUniversidad Complutense de Madrid20242024-04-1920242024-04-19journal articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/20.500.14352/123871reponame:Docta Complutenseinstname:Universidad Complutense de Madrid (UCM)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2info:eu-repo/semantics/openAccessoai:docta.ucm.es:20.500.14352/1238712026-06-02T12:44:21Z
dc.title.none.fl_str_mv Breaking barriers in electrochemical biosensing using bioinspired peptide and phage probes
title Breaking barriers in electrochemical biosensing using bioinspired peptide and phage probes
spellingShingle Breaking barriers in electrochemical biosensing using bioinspired peptide and phage probes
Campuzano Ruiz, Susana
543
Electrochemical biosensing
Peptides
Phage probes
Phage display
Mimotopes
Ciencias
23 Química
title_short Breaking barriers in electrochemical biosensing using bioinspired peptide and phage probes
title_full Breaking barriers in electrochemical biosensing using bioinspired peptide and phage probes
title_fullStr Breaking barriers in electrochemical biosensing using bioinspired peptide and phage probes
title_full_unstemmed Breaking barriers in electrochemical biosensing using bioinspired peptide and phage probes
title_sort Breaking barriers in electrochemical biosensing using bioinspired peptide and phage probes
dc.creator.none.fl_str_mv Campuzano Ruiz, Susana
Pedrero Muñoz, María
Barderas Manchado, Rodrigo
Pingarrón Carrazón, José Manuel
author Campuzano Ruiz, Susana
author_facet Campuzano Ruiz, Susana
Pedrero Muñoz, María
Barderas Manchado, Rodrigo
Pingarrón Carrazón, José Manuel
author_role author
author2 Pedrero Muñoz, María
Barderas Manchado, Rodrigo
Pingarrón Carrazón, José Manuel
author2_role author
author
author
dc.contributor.none.fl_str_mv Universidad Complutense de Madrid
dc.subject.none.fl_str_mv 543
Electrochemical biosensing
Peptides
Phage probes
Phage display
Mimotopes
Ciencias
23 Química
topic 543
Electrochemical biosensing
Peptides
Phage probes
Phage display
Mimotopes
Ciencias
23 Química
description Electrochemical biosensing continues to advance tirelessly, overcoming barriers that have kept it from leaving research laboratories for many years. Among them, its compromised performance in complex biological matrices due to fouling or receptor stability issues, the limitations in determining toxic and small analytes, and its use, conditioned to the commercial availability of commercial receptors and the exploration of natural molecular interactions, deserved to be highlighted. To address these challenges, in addition to the intrinsic properties of electrochemical biosensing, its coupling with biomimetic materials has played a fundamental role, among which bioinspired phage and peptide probes stand out. The versatility in design and employment of these probes has opened an unimaginable plethora of possibilities for electrochemical biosensing, improving their performance far beyond the development of highly sensitive and selective devices. The state of the art offers robust electroanalytical biotools, capable of operating in complex samples and with exciting opportunities to discover and determine targets regardless of their toxicity and size, the commercial availability of bioreceptors, and prior knowledge of molecular interactions. With all this in mind, this review offers a panoramic, novel, and updated vision of both the tremendous advances and opportunities offered by the combination of electrochemical biosensors with bioinspired phage and peptide probes and the challenges and research efforts that are envisioned in the immediate future.
publishDate 2024
dc.date.none.fl_str_mv 2024
2024-04-19
2024
2024-04-19
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/20.500.14352/123871
url https://hdl.handle.net/20.500.14352/123871
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Springer
publisher.none.fl_str_mv Springer
dc.source.none.fl_str_mv reponame:Docta Complutense
instname:Universidad Complutense de Madrid (UCM)
instname_str Universidad Complutense de Madrid (UCM)
reponame_str Docta Complutense
collection Docta Complutense
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,812429

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