Association of Functional Polymorphisms of KIR3DL1/DS1 With Behcet's Disease

Behcet's disease (BD) is an immune-mediated vasculitis related to imbalances between the innate and adaptive immune response. Infectious agents or environmental factors may trigger the disease in genetically predisposed individuals. HLA-B51 is the genetic factor stronger associated with the dis...

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Detalles Bibliográficos
Autores: Castano-Nunez, A, Montes-Cano, MA, Garcia-Lozano, JR, Ortego-Centeno, N, Garcia-Hernandez, FJ, Espinosa, G, Graña Gil, Genaro, Sanchez-Burson, J, Julia, MR, Solans, R, Blanco, R, Barnosi-Marin, AC, de la Torre, RG, Fanlo, P, Rodriguez-Carballeira, M, Rodriguez-Rodriguez, L, Camps, T, Castaneda, S, Alegre-Sancho, JJ, Martin, J, Gonzalez-Escribano, MF
Tipo de recurso: artículo
Fecha de publicación:2019
País:España
Institución:Servizo Galego de Saúde (SERGAS)
Repositorio:RUNA. Repositorio da Consellería de Sanidade e Sergas
OAI Identifier:oai:runa.sergas.gal:20.500.11940/16074
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6896819/pdf/fimmu-10-02755.pdf
http://hdl.handle.net/20.500.11940/16074
Access Level:acceso abierto
Palabra clave:Odds Ratio
Humans
Genetic Association Studies
HLA Antigens
Behcet Syndrome
Genetic Predisposition to Disease
Genotype
Gene Frequency
Alleles
cociente de probabilidades relativas
estudios de asociación genética
genotipo
frecuencia génica
síndrome de Behçet
antígenos HLA
humanos
alelos
predisposición genética a la enfermedad
CHUAC
Descripción
Sumario:Behcet's disease (BD) is an immune-mediated vasculitis related to imbalances between the innate and adaptive immune response. Infectious agents or environmental factors may trigger the disease in genetically predisposed individuals. HLA-B51 is the genetic factor stronger associated with the disease, although the bases of this association remain elusive. NK cells have also been implicated in the etiopathogenesis of BD. A family of NK receptors, Killer-cell Immunoglobulin-like Receptor (KIR), with a very complex organization, is very important in the education and control of the NK cells by the union to their ligands, most of them, HLA class I molecules. This study aimed to investigate the contribution of certain KIR functional polymorphisms to the susceptibility to BD. A total of 466 BD patients and 444 healthy individuals were genotyped in HLA class I (A, B, and C). The set of KIR genes and the functional variants of KIR3DL1/DS1 and KIR2DS4 were also determined. Frequency of KIR3DL1(*)004 was lower in patients than in controls (0.15 vs. 0.20, P = 0.005, Pc = 0.015; OR = 0.70; 95% CI 0.54-0.90) in both B51 positive and negative individuals. KIR3DL1(*)004, which encodes a misfolded protein, is included in a common telomeric haplotype with only one functional KIR gene, KIR3DL2. Both, KIR3DL1 and KIR3DL2 sense pathogen-associated molecular patterns but they have different capacities to eliminate them. The education of the NK cells depending on the HLA, the balance of KIR3DL1/KIR3DL2 licensed NK cells and the different capacities of these receptors to eliminate pathogens could be involved in the etiopathogenesis of BD.