Determining the role of the zinc-finger protein ZMYM2 in pluripotency

Mutations of the zinc finger MYM-type containing 2 (ZMYM2) protein alter cellular and tissue homeostasis, but its functional roles in pluripotency are largely unexplored. Here, I show that ZMYM2 is a key component of the core regulatory network that governs pluripotency. My data reveal that ZMYM2 is...

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Detalles Bibliográficos
Autor: Souto Becerra, Yara
Tipo de recurso: tesis doctoral
Fecha de publicación:2022
País:España
Institución:Universidad de Santiago de Compostela (USC)
Repositorio:Minerva. Repositorio Institucional de la Universidad de Santiago de Compostela
Idioma:inglés
OAI Identifier:oai:minerva.usc.gal:10347/28763
Acceso en línea:http://hdl.handle.net/10347/28763
Access Level:acceso abierto
Palabra clave:Materias::Investigación::24 Ciencias de la vida::2407 Biología celular::240701 Cultivo celular
Descripción
Sumario:Mutations of the zinc finger MYM-type containing 2 (ZMYM2) protein alter cellular and tissue homeostasis, but its functional roles in pluripotency are largely unexplored. Here, I show that ZMYM2 is a key component of the core regulatory network that governs pluripotency. My data reveal that ZMYM2 is a roadblock to efficient somatic cell reprogramming and is required to fine-tune the self-renewal of ESCs and the early differentiation process. Mechanistically, I found that ZMYM2 and LSD1 associate for the transcriptional control of pluripotency and differentiation genes. This study therefore establishes a novel transcriptional regulatory mode dedicated to reprogramming and pluripotency, and open new avenues for exploring the involvement of ZMYM2- LSD1 partnership in development and disease.

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