PDGF-BB serum levels are decreased in adult onset Pompe patients

Adult onset Pompe disease is a genetic disorder characterized by slowly progressive skeletal and respiratory muscle weakness. Symptomatic patients are treated with enzymatic replacement therapy with human recombinant alfa glucosidase. Motor functional tests and spirometry are commonly used to follow...

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Detalles Bibliográficos
Autores: Fernandez-Simon, E, Carrasco-Rozas, A, Gallardo, E, Figueroa-Bonaparte, S, Belmonte, I, Pedrosa, I, Montiel, E, Suarez-Calvet, X, Alonso-Perez, J, Segovia, S, Nunez-Peralta, C, Llauger, J, Mayos, M, Illa, I, Diaz-Manera, J, Barba-Romero, MA, Barcena, J, Carzorla, MR, Creus, C, Coll-Canti, J, de Luna, N, Diaz, M, Dominguez, C, Fernandez-Torron, R, Garcia-Antelo, MJ, Grau, JM, Gomez-Caravaca, MT, Leon-Hernandez, JC, de Munain, AL, Martinez-Garcia, FA, Morgado, Y, Moreno, A, Moris, G, Munoz-Blanco, MA, Nascimento, A, Paradas, C, Parajua-Pozo, JL, Querol, L, Robledo-Strauss, A, Rojas-Garcia, R, Rojas-Marcos, I, Salazar, JA, Uson, M
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2019
País:España
Institución:Institut d’Investigació Biomèdica Sant Pau (IIB Sant Pau)
Repositorio:r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
OAI Identifier:oai:iibsantpau.fundanetsuite.com:p2330
Acceso en línea:https://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=2330
http://ddd.uab.cat/record/223847
Access Level:acceso abierto
Descripción
Sumario:Adult onset Pompe disease is a genetic disorder characterized by slowly progressive skeletal and respiratory muscle weakness. Symptomatic patients are treated with enzymatic replacement therapy with human recombinant alfa glucosidase. Motor functional tests and spirometry are commonly used to follow patients up. However, a serological biomarker that correlates with the progression of the disease could improve follow-up. We studied serum concentrations of TGF beta, PDGF-BB, PDGF-AA and CTGF growth factors in 37 adult onset Pompe patients and 45 controls. Moreover, all patients performed several muscle function tests, conventional spirometry, and quantitative muscle MRI using 3-point Dixon. We observed a statistically significant change in the serum concentration of each growth factor in patients compared to controls. However, only PDGF-BB levels were able to differentiate between asymptomatic and symptomatic patients, suggesting its potential role in the follow-up of asymptomatic patients. Moreover, our results point to a dysregulation of muscle regeneration as an additional pathomechanism of Pompe disease.

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