Phytoestrogen metabolism by adult human gut microbiota

Phytoestrogens are plant-derived polyphenols with a structure similar to human estrogens. The three main groups of phytoestrogens, isoflavones, ellagitannins, and lignans, are transformed into equol, urolithins, and enterolignans, respectively, by bacteria. These metabolites have more estrogenic/ant...

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Autores: Gaya Sicilia, María Pilar, Medina, Milagros, Sánchez-Jiménez, A., Landete, José María
Tipo de recurso: artículo
Fecha de publicación:2016
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/290168
Acceso en línea:http://hdl.handle.net/10261/290168
Access Level:acceso abierto
Palabra clave:Phytoestrogens
Microbiota
Equol
Urolithins
Enterolignans
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spelling Phytoestrogen metabolism by adult human gut microbiotaGaya Sicilia, María PilarMedina, MilagrosSánchez-Jiménez, A.Landete, José MaríaPhytoestrogensMicrobiotaEquolUrolithinsEnterolignansPhytoestrogens are plant-derived polyphenols with a structure similar to human estrogens. The three main groups of phytoestrogens, isoflavones, ellagitannins, and lignans, are transformed into equol, urolithins, and enterolignans, respectively, by bacteria. These metabolites have more estrogenic/antiestrogenic and antioxidant activities than their precursors, and they are more bioavailable. The aim of this study was to analyze the metabolism of isoflavones, lignans and ellagitannins by gut microbiota, and to study the possible correlation in the metabolism of these three groups of phytoestrogens. In vitro fermentation experiments were performed with feces samples from 14 healthy adult volunteers, and metabolite formation was measured by HPLC-PAD and HPLC-ESI/MS. Only the microbiota of one subject produced equol, while most of them showed production of O-desmethylangolensin (O-DMA). Significant inter-subject differences were observed in the metabolism of dihydrodaidzein and dihydrogenistein, while the glucoside isoflavones and their aglycones showed less variability, except for glycitin. Most subjects produced urolithins M-5 and E. Urolithin D was not detected, while uroltithin B was found in half of the individuals analyzed, and urolithins A and C were detected in two and four subjects, respectively. Enterolactone was found in all subjects, while enterodiol only appeared in five. Isoflavone metabolism could be correlated with the metabolism of lignans and ellagitannins. However, the metabolism of ellagitannins and lignans could not be correlated. This the first study where the metabolism of the three groups together of phytoestrogen, isoflavones, lignans, and ellagitannins by gut microbiota is analyzed. © 2016 by the authors; licensee MDPI.Peer reviewedMultidisciplinary Digital Publishing InstituteLandete, José María [0000-0002-5147-3989]Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]202320232016info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501http://hdl.handle.net/10261/290168reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)InglésDepartamento de Tecnología de AlimentosSíinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/2901682026-05-22T06:33:51Z
dc.title.none.fl_str_mv Phytoestrogen metabolism by adult human gut microbiota
title Phytoestrogen metabolism by adult human gut microbiota
spellingShingle Phytoestrogen metabolism by adult human gut microbiota
Gaya Sicilia, María Pilar
Phytoestrogens
Microbiota
Equol
Urolithins
Enterolignans
title_short Phytoestrogen metabolism by adult human gut microbiota
title_full Phytoestrogen metabolism by adult human gut microbiota
title_fullStr Phytoestrogen metabolism by adult human gut microbiota
title_full_unstemmed Phytoestrogen metabolism by adult human gut microbiota
title_sort Phytoestrogen metabolism by adult human gut microbiota
dc.creator.none.fl_str_mv Gaya Sicilia, María Pilar
Medina, Milagros
Sánchez-Jiménez, A.
Landete, José María
author Gaya Sicilia, María Pilar
author_facet Gaya Sicilia, María Pilar
Medina, Milagros
Sánchez-Jiménez, A.
Landete, José María
author_role author
author2 Medina, Milagros
Sánchez-Jiménez, A.
Landete, José María
author2_role author
author
author
dc.contributor.none.fl_str_mv Landete, José María [0000-0002-5147-3989]
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Phytoestrogens
Microbiota
Equol
Urolithins
Enterolignans
topic Phytoestrogens
Microbiota
Equol
Urolithins
Enterolignans
description Phytoestrogens are plant-derived polyphenols with a structure similar to human estrogens. The three main groups of phytoestrogens, isoflavones, ellagitannins, and lignans, are transformed into equol, urolithins, and enterolignans, respectively, by bacteria. These metabolites have more estrogenic/antiestrogenic and antioxidant activities than their precursors, and they are more bioavailable. The aim of this study was to analyze the metabolism of isoflavones, lignans and ellagitannins by gut microbiota, and to study the possible correlation in the metabolism of these three groups of phytoestrogens. In vitro fermentation experiments were performed with feces samples from 14 healthy adult volunteers, and metabolite formation was measured by HPLC-PAD and HPLC-ESI/MS. Only the microbiota of one subject produced equol, while most of them showed production of O-desmethylangolensin (O-DMA). Significant inter-subject differences were observed in the metabolism of dihydrodaidzein and dihydrogenistein, while the glucoside isoflavones and their aglycones showed less variability, except for glycitin. Most subjects produced urolithins M-5 and E. Urolithin D was not detected, while uroltithin B was found in half of the individuals analyzed, and urolithins A and C were detected in two and four subjects, respectively. Enterolactone was found in all subjects, while enterodiol only appeared in five. Isoflavone metabolism could be correlated with the metabolism of lignans and ellagitannins. However, the metabolism of ellagitannins and lignans could not be correlated. This the first study where the metabolism of the three groups together of phytoestrogen, isoflavones, lignans, and ellagitannins by gut microbiota is analyzed. © 2016 by the authors; licensee MDPI.
publishDate 2016
dc.date.none.fl_str_mv 2016
2023
2023
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/290168
url http://hdl.handle.net/10261/290168
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Departamento de Tecnología de Alimentos
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute
publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,811543

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