Effect of serotonin axon injury on the somatostatinergic system in rat frontoparietal cortex
In order to investigate the possibility that, in the rat, some cerebral cortex somatostatin (SS) receptors may be localized presynaptically on the terminals of serotonergic neurons, serotonin [5-hydroxytryptamine, (5-HT)] neurons in the central nervous system were damaged with a local intracerebral...
| Autores: | , , |
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| Tipo de recurso: | artículo |
| Fecha de publicación: | 1993 |
| País: | España |
| Institución: | Universidad de Alcalá (UAH) |
| Repositorio: | e_Buah Biblioteca Digital Universidad de Alcalá |
| Idioma: | inglés |
| OAI Identifier: | oai:ebuah.uah.es:10017/2980 |
| Acceso en línea: | http://hdl.handle.net/10017/2980 https://dx.doi.org/10.1016/0024-3205(93)90078-H |
| Access Level: | acceso abierto |
| Palabra clave: | Serotonin Somatostatin Frontoparietal cortex Bioquímica Ciencia Biochemistry Science |
| Sumario: | In order to investigate the possibility that, in the rat, some cerebral cortex somatostatin (SS) receptors may be localized presynaptically on the terminals of serotonergic neurons, serotonin [5-hydroxytryptamine, (5-HT)] neurons in the central nervous system were damaged with a local intracerebral injection of the serotonergic neurotoxin, 5,7-dihydroxytryptamine (5,7-DHT). The injection of 5,7- DHT (11 /~g free base dissolved in 10 t~l of isotonic saline containing 0.01% ascorbic acid) in rats produced an reduction by about 74 % in frontoparietal cortical 5-HT content at 1 and 3 weeks after injection. These changes were associated with a significant decrease by about 30 % in the total number of specific SS receptors in the frontoparietal cortex at both times studied without influencing the apparent affinity of the receptors. Together, these results suggest that a portion of the frontoparietal cortex SS receptors may be localized presynaptically on the serotonergic nerve terminals. The 5,7-DHT did not affect SS-like immunoreactivity (SSLI) levels suggesting that SS and 5-HT are not colocalized within the same neuronal elements in the rat frontoparietal cortex. |
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