Efficacy of a benzothiazole-based LRRK2 inhibitor in oligodendrocyte precursor cells and in a murine model of multiple sclerosis

Multiple sclerosis (MS) is a chronic neurological disease that currently lacks effective curative treatments. There is a need to find effective therapies, especially to reverse the progressive demyelination and neuronal damage. Oligodendrocytes form the myelin sheath around axons in the central nerv...

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Autores: Benítez-Fernández, Rocío, Josa-Prado, Fernando, Sánchez, Estefanía, Lao, Yolanda, García-Rubia, Alfonso, Cumella, José, Martínez, Ana, Palomo, Valle, Castro Soubriet, Fernando de
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2024
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/366896
Acceso en línea:http://hdl.handle.net/10261/366896
https://api.elsevier.com/content/abstract/scopus_id/85183030064
Access Level:acceso abierto
Palabra clave:LRRK2 inhibitors
multiple sclerosis
remyelinating agents
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spelling Efficacy of a benzothiazole-based LRRK2 inhibitor in oligodendrocyte precursor cells and in a murine model of multiple sclerosisBenítez-Fernández, RocíoJosa-Prado, FernandoSánchez, EstefaníaLao, YolandaGarcía-Rubia, AlfonsoCumella, JoséMartínez, AnaPalomo, ValleCastro Soubriet, Fernando deLRRK2 inhibitorsmultiple sclerosisremyelinating agentsMultiple sclerosis (MS) is a chronic neurological disease that currently lacks effective curative treatments. There is a need to find effective therapies, especially to reverse the progressive demyelination and neuronal damage. Oligodendrocytes form the myelin sheath around axons in the central nervous system (CNS) and oligodendrocyte precursor cells (OPCs) undergo mechanisms that enable spontaneously the partial repair of damaged lesions. The aim of this study was to discover small molecules with potential effects in demyelinating diseases, including (re)myelinating properties.Comunidad de Madrid, Grant/Award Number: PEJ-2019-TL/BMD-1426; Consejo Superior de Investigaciones Científicas, Grant/Award Number: 2023AEP096; Fundación Ramón Areces, Grant/Award Number: CIVP19A5917; Ministerio de Ciencia e Innovación, Grant/ Award Number: PID2019-109858RB-I00, PID2022-143110OB-I00 and RYC2019- 027489-IPeer reviewedJohn Wiley & SonsComunidad de MadridConsejo Superior de Investigaciones Científicas (España)Fundación Ramón ArecesMinisterio de Ciencia e Innovación (España)Josa-Prado, Fernando [0000-0002-6162-3231]Martínez, Ana [0000-0002-2707-8110]Palomo, Valle [0000-0002-1473-4086]de Castro, Fernando [0000-0002-7018-8032]Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]202420242024info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionhttp://hdl.handle.net/10261/366896https://api.elsevier.com/content/abstract/scopus_id/85183030064reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Inglés#PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE#info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PID2019-109858RB-I00info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2021-2023/PID2022-143110OB-I00CNS neuroscience & therapeuticsapplication/pdfhttps://onlinelibrary.wiley.com/doi/10.1111/cns.14552Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/3668962026-05-22T06:33:51Z
dc.title.none.fl_str_mv Efficacy of a benzothiazole-based LRRK2 inhibitor in oligodendrocyte precursor cells and in a murine model of multiple sclerosis
title Efficacy of a benzothiazole-based LRRK2 inhibitor in oligodendrocyte precursor cells and in a murine model of multiple sclerosis
spellingShingle Efficacy of a benzothiazole-based LRRK2 inhibitor in oligodendrocyte precursor cells and in a murine model of multiple sclerosis
Benítez-Fernández, Rocío
LRRK2 inhibitors
multiple sclerosis
remyelinating agents
title_short Efficacy of a benzothiazole-based LRRK2 inhibitor in oligodendrocyte precursor cells and in a murine model of multiple sclerosis
title_full Efficacy of a benzothiazole-based LRRK2 inhibitor in oligodendrocyte precursor cells and in a murine model of multiple sclerosis
title_fullStr Efficacy of a benzothiazole-based LRRK2 inhibitor in oligodendrocyte precursor cells and in a murine model of multiple sclerosis
title_full_unstemmed Efficacy of a benzothiazole-based LRRK2 inhibitor in oligodendrocyte precursor cells and in a murine model of multiple sclerosis
title_sort Efficacy of a benzothiazole-based LRRK2 inhibitor in oligodendrocyte precursor cells and in a murine model of multiple sclerosis
dc.creator.none.fl_str_mv Benítez-Fernández, Rocío
Josa-Prado, Fernando
Sánchez, Estefanía
Lao, Yolanda
García-Rubia, Alfonso
Cumella, José
Martínez, Ana
Palomo, Valle
Castro Soubriet, Fernando de
author Benítez-Fernández, Rocío
author_facet Benítez-Fernández, Rocío
Josa-Prado, Fernando
Sánchez, Estefanía
Lao, Yolanda
García-Rubia, Alfonso
Cumella, José
Martínez, Ana
Palomo, Valle
Castro Soubriet, Fernando de
author_role author
author2 Josa-Prado, Fernando
Sánchez, Estefanía
Lao, Yolanda
García-Rubia, Alfonso
Cumella, José
Martínez, Ana
Palomo, Valle
Castro Soubriet, Fernando de
author2_role author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Comunidad de Madrid
Consejo Superior de Investigaciones Científicas (España)
Fundación Ramón Areces
Ministerio de Ciencia e Innovación (España)
Josa-Prado, Fernando [0000-0002-6162-3231]
Martínez, Ana [0000-0002-2707-8110]
Palomo, Valle [0000-0002-1473-4086]
de Castro, Fernando [0000-0002-7018-8032]
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv LRRK2 inhibitors
multiple sclerosis
remyelinating agents
topic LRRK2 inhibitors
multiple sclerosis
remyelinating agents
description Multiple sclerosis (MS) is a chronic neurological disease that currently lacks effective curative treatments. There is a need to find effective therapies, especially to reverse the progressive demyelination and neuronal damage. Oligodendrocytes form the myelin sheath around axons in the central nervous system (CNS) and oligodendrocyte precursor cells (OPCs) undergo mechanisms that enable spontaneously the partial repair of damaged lesions. The aim of this study was to discover small molecules with potential effects in demyelinating diseases, including (re)myelinating properties.
publishDate 2024
dc.date.none.fl_str_mv 2024
2024
2024
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/366896
https://api.elsevier.com/content/abstract/scopus_id/85183030064
url http://hdl.handle.net/10261/366896
https://api.elsevier.com/content/abstract/scopus_id/85183030064
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv #PLACEHOLDER_PARENT_METADATA_VALUE#
#PLACEHOLDER_PARENT_METADATA_VALUE#
info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PID2019-109858RB-I00
info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2021-2023/PID2022-143110OB-I00
CNS neuroscience & therapeutics
application/pdf
https://onlinelibrary.wiley.com/doi/10.1111/cns.14552
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv John Wiley & Sons
publisher.none.fl_str_mv John Wiley & Sons
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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