Working Memory Deficits After Lesions Involving the Supplementary Motor Area

The Supplementary Motor Area (SMA)¿located in the superior and medial aspects of the superior frontal gyrus¿is a preferential site of certain brain tumors and arteriovenous malformations, which often provoke the so-called SMA syndrome. The bulk of the literature studying this syndrome has focused on...

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Autores: Cañas, Alba, Juncadella i Puig, Montserrat, Lau, Ruth, Gabarrós, Andreu, Hernández Pardo, Mireia
Formato: artículo
Estado:Versión publicada
Fecha de publicación:2018
País:España
Recursos:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/145955
Acesso em linha:https://hdl.handle.net/2445/145955
Access Level:acceso abierto
Palavra-chave:Memòria
Escorça cerebral
Motricitat
Lesions cerebrals
Memory
Cerebral cortex
Motor ability
Brain damage
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spelling Working Memory Deficits After Lesions Involving the Supplementary Motor AreaCañas, AlbaJuncadella i Puig, MontserratLau, RuthGabarrós, AndreuHernández Pardo, MireiaMemòriaEscorça cerebralMotricitatLesions cerebralsMemoryCerebral cortexMotor abilityBrain damageThe Supplementary Motor Area (SMA)¿located in the superior and medial aspects of the superior frontal gyrus¿is a preferential site of certain brain tumors and arteriovenous malformations, which often provoke the so-called SMA syndrome. The bulk of the literature studying this syndrome has focused on two of its most apparent symptoms: contralateral motor and speech deficits. Surprisingly, little attention has been given to working memory (WM) even though neuroimaging studies have implicated the SMA in this cognitive process. Given its relevance for higher-order functions, our main goal was to examine whether WM is compromised in SMA lesions. We also asked whether WM deficits might be reducible to processing speed (PS) difficulties. Given the connectivity of the SMA with prefrontal regions related to executive control (EC), as a secondary goal we examined whether SMA lesions also hampered EC. To this end, we tested 12 patients with lesions involving the left (i.e., the dominant) SMA. We also tested 12 healthy controls matched with patients for socio-demographic variables. To ensure that the results of this study can be easily transferred and implemented in clinical practice, we used widely-known clinical neuropsychological tests: WM and PS were measured with their respective Wechsler Adult Intelligence Scale indexes, and EC was tested with phonemic and semantic verbal fluency tasks. Non-parametric statistical methods revealed that patients showed deficits in the executive component of WM: they were able to sustain information temporarily but not to mentally manipulate this information. Such WM deficits were not subject to patients' marginal PS impairment. Patients also showed reduced phonemic fluency, which disappeared after controlling for the influence of WM. This observation suggests that SMA damage does not seem to affect cognitive processes engaged by verbal fluency other than WM. In conclusion, WM impairment needs to be considered as part of the SMA syndrome. These findings represent the first evidence about the cognitive consequences (other than language) of damage to the SMA. Further research is needed to establish a more specific profile of WM impairment in SMA patients and determine the consequences of SMA damage for other cognitive functions.Frontiers Media2019201920182019info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion12 p.application/pdfhttps://hdl.handle.net/2445/145955Articles publicats en revistes (Cognició, Desenvolupament i Psicologia de l'Educació)reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésReproducció del document publicat a: https://doi.org/10.3389/fpsyg.2018.00765Frontiers in Psychology, 2018, vol. 9, p. 765https://doi.org/10.3389/fpsyg.2018.00765cc-by (c) Cañas, Alba et al., 2018http://creativecommons.org/licenses/by/3.0/esinfo:eu-repo/semantics/openAccessoai:recercat.cat:2445/1459552026-05-29T05:05:01Z
dc.title.none.fl_str_mv Working Memory Deficits After Lesions Involving the Supplementary Motor Area
title Working Memory Deficits After Lesions Involving the Supplementary Motor Area
spellingShingle Working Memory Deficits After Lesions Involving the Supplementary Motor Area
Cañas, Alba
Memòria
Escorça cerebral
Motricitat
Lesions cerebrals
Memory
Cerebral cortex
Motor ability
Brain damage
title_short Working Memory Deficits After Lesions Involving the Supplementary Motor Area
title_full Working Memory Deficits After Lesions Involving the Supplementary Motor Area
title_fullStr Working Memory Deficits After Lesions Involving the Supplementary Motor Area
title_full_unstemmed Working Memory Deficits After Lesions Involving the Supplementary Motor Area
title_sort Working Memory Deficits After Lesions Involving the Supplementary Motor Area
dc.creator.none.fl_str_mv Cañas, Alba
Juncadella i Puig, Montserrat
Lau, Ruth
Gabarrós, Andreu
Hernández Pardo, Mireia
author Cañas, Alba
author_facet Cañas, Alba
Juncadella i Puig, Montserrat
Lau, Ruth
Gabarrós, Andreu
Hernández Pardo, Mireia
author_role author
author2 Juncadella i Puig, Montserrat
Lau, Ruth
Gabarrós, Andreu
Hernández Pardo, Mireia
author2_role author
author
author
author
dc.subject.none.fl_str_mv Memòria
Escorça cerebral
Motricitat
Lesions cerebrals
Memory
Cerebral cortex
Motor ability
Brain damage
topic Memòria
Escorça cerebral
Motricitat
Lesions cerebrals
Memory
Cerebral cortex
Motor ability
Brain damage
description The Supplementary Motor Area (SMA)¿located in the superior and medial aspects of the superior frontal gyrus¿is a preferential site of certain brain tumors and arteriovenous malformations, which often provoke the so-called SMA syndrome. The bulk of the literature studying this syndrome has focused on two of its most apparent symptoms: contralateral motor and speech deficits. Surprisingly, little attention has been given to working memory (WM) even though neuroimaging studies have implicated the SMA in this cognitive process. Given its relevance for higher-order functions, our main goal was to examine whether WM is compromised in SMA lesions. We also asked whether WM deficits might be reducible to processing speed (PS) difficulties. Given the connectivity of the SMA with prefrontal regions related to executive control (EC), as a secondary goal we examined whether SMA lesions also hampered EC. To this end, we tested 12 patients with lesions involving the left (i.e., the dominant) SMA. We also tested 12 healthy controls matched with patients for socio-demographic variables. To ensure that the results of this study can be easily transferred and implemented in clinical practice, we used widely-known clinical neuropsychological tests: WM and PS were measured with their respective Wechsler Adult Intelligence Scale indexes, and EC was tested with phonemic and semantic verbal fluency tasks. Non-parametric statistical methods revealed that patients showed deficits in the executive component of WM: they were able to sustain information temporarily but not to mentally manipulate this information. Such WM deficits were not subject to patients' marginal PS impairment. Patients also showed reduced phonemic fluency, which disappeared after controlling for the influence of WM. This observation suggests that SMA damage does not seem to affect cognitive processes engaged by verbal fluency other than WM. In conclusion, WM impairment needs to be considered as part of the SMA syndrome. These findings represent the first evidence about the cognitive consequences (other than language) of damage to the SMA. Further research is needed to establish a more specific profile of WM impairment in SMA patients and determine the consequences of SMA damage for other cognitive functions.
publishDate 2018
dc.date.none.fl_str_mv 2018
2019
2019
2019
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/145955
url https://hdl.handle.net/2445/145955
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.3389/fpsyg.2018.00765
Frontiers in Psychology, 2018, vol. 9, p. 765
https://doi.org/10.3389/fpsyg.2018.00765
dc.rights.none.fl_str_mv cc-by (c) Cañas, Alba et al., 2018
http://creativecommons.org/licenses/by/3.0/es
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc-by (c) Cañas, Alba et al., 2018
http://creativecommons.org/licenses/by/3.0/es
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 12 p.
application/pdf
dc.publisher.none.fl_str_mv Frontiers Media
publisher.none.fl_str_mv Frontiers Media
dc.source.none.fl_str_mv Articles publicats en revistes (Cognició, Desenvolupament i Psicologia de l'Educació)
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.812429

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