Rodent models and metabolomics in non-alcoholic fatty liver disease: What can we learn?

Non-alcoholic fatty liver disease (NAFLD) prevalence has increased drastically in recent decades, affecting up to 25% of the world's population. NAFLD is a spectrum of different diseases that starts with asymptomatic steatosis and continues with development of an inflammatory response called st...

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Detalhes bibliográficos
Autores: Martin-Grau, M, Marrachelli, VG, Monleon, D
Tipo de documento: artigo
Estado:Versão publicada
Data de publicação:2022
País:España
Recursos:INCLIVA
Repositório:r-INCLIVA. Repositorio Institucional de Producción Científica de INCLIVA
OAI Identifier:oai:incliva.fundanetsuite.com:p16657
Acesso em linha:https://incliva.portalinvestigacion.com/publicaciones/16657
Access Level:Acceso aberto
Palavra-chave:Biomarkers
Liver disease
Metabolic profiling
Metabolomics
Non-alcoholic fatty liver disease
Rodent models
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spelling Rodent models and metabolomics in non-alcoholic fatty liver disease: What can we learn?Martin-Grau, MMarrachelli, VGMonleon, DBiomarkersLiver diseaseMetabolic profilingMetabolomicsNon-alcoholic fatty liver diseaseRodent modelsNon-alcoholic fatty liver disease (NAFLD) prevalence has increased drastically in recent decades, affecting up to 25% of the world's population. NAFLD is a spectrum of different diseases that starts with asymptomatic steatosis and continues with development of an inflammatory response called steatohepatitis, which can progress to fibrosis. Several molecular and metabolic changes are required for the hepatocyte to finally vary its function; hence a "multiple hit" hypothesis seems a more accurate proposal. Previous studies and current knowledge suggest that in most cases, NAFLD initiates and progresses through most of nine hallmarks of the disease, although the triggers and mechanisms for these can vary widely. The use of animal models remains crucial for understanding the disease and for developing tools based on biological knowledge. Among certain requirements to be met, a good model must imitate certain aspects of the human NAFLD disorder, be reliable and reproducible, have low mortality, and be compatible with a simple and feasible method. Metabolism studies in these models provides a direct reflection of the workings of the cell and may be a useful approach to better understand the initiation and progression of the disease. Metabolomics seems a valid tool for studying metabolic pathways and crosstalk between organs affected in animal models of NAFLD and for the discovery and validation of relevant biomarkers with biological understanding. In this review, we provide a brief introduction to NAFLD hallmarks, the five groups of animal models available for studying NAFLD and the potential role of metabolomics in the study of experimental NAFLD.BAISHIDENG PUBLISHING GROUP INC2022info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://incliva.portalinvestigacion.com/publicaciones/16657World Journal of HepatologyISSN: 19485182reponame:r-INCLIVA. Repositorio Institucional de Producción Científica de INCLIVAinstname:INCLIVAInglésinfo:eu-repo/semantics/openAccessoai:incliva.fundanetsuite.com:p166572026-06-07T16:35:31Z
dc.title.none.fl_str_mv Rodent models and metabolomics in non-alcoholic fatty liver disease: What can we learn?
title Rodent models and metabolomics in non-alcoholic fatty liver disease: What can we learn?
spellingShingle Rodent models and metabolomics in non-alcoholic fatty liver disease: What can we learn?
Martin-Grau, M
Biomarkers
Liver disease
Metabolic profiling
Metabolomics
Non-alcoholic fatty liver disease
Rodent models
title_short Rodent models and metabolomics in non-alcoholic fatty liver disease: What can we learn?
title_full Rodent models and metabolomics in non-alcoholic fatty liver disease: What can we learn?
title_fullStr Rodent models and metabolomics in non-alcoholic fatty liver disease: What can we learn?
title_full_unstemmed Rodent models and metabolomics in non-alcoholic fatty liver disease: What can we learn?
title_sort Rodent models and metabolomics in non-alcoholic fatty liver disease: What can we learn?
dc.creator.none.fl_str_mv Martin-Grau, M
Marrachelli, VG
Monleon, D
author Martin-Grau, M
author_facet Martin-Grau, M
Marrachelli, VG
Monleon, D
author_role author
author2 Marrachelli, VG
Monleon, D
author2_role author
author
dc.subject.none.fl_str_mv Biomarkers
Liver disease
Metabolic profiling
Metabolomics
Non-alcoholic fatty liver disease
Rodent models
topic Biomarkers
Liver disease
Metabolic profiling
Metabolomics
Non-alcoholic fatty liver disease
Rodent models
description Non-alcoholic fatty liver disease (NAFLD) prevalence has increased drastically in recent decades, affecting up to 25% of the world's population. NAFLD is a spectrum of different diseases that starts with asymptomatic steatosis and continues with development of an inflammatory response called steatohepatitis, which can progress to fibrosis. Several molecular and metabolic changes are required for the hepatocyte to finally vary its function; hence a "multiple hit" hypothesis seems a more accurate proposal. Previous studies and current knowledge suggest that in most cases, NAFLD initiates and progresses through most of nine hallmarks of the disease, although the triggers and mechanisms for these can vary widely. The use of animal models remains crucial for understanding the disease and for developing tools based on biological knowledge. Among certain requirements to be met, a good model must imitate certain aspects of the human NAFLD disorder, be reliable and reproducible, have low mortality, and be compatible with a simple and feasible method. Metabolism studies in these models provides a direct reflection of the workings of the cell and may be a useful approach to better understand the initiation and progression of the disease. Metabolomics seems a valid tool for studying metabolic pathways and crosstalk between organs affected in animal models of NAFLD and for the discovery and validation of relevant biomarkers with biological understanding. In this review, we provide a brief introduction to NAFLD hallmarks, the five groups of animal models available for studying NAFLD and the potential role of metabolomics in the study of experimental NAFLD.
publishDate 2022
dc.date.none.fl_str_mv 2022
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://incliva.portalinvestigacion.com/publicaciones/16657
url https://incliva.portalinvestigacion.com/publicaciones/16657
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv BAISHIDENG PUBLISHING GROUP INC
publisher.none.fl_str_mv BAISHIDENG PUBLISHING GROUP INC
dc.source.none.fl_str_mv World Journal of Hepatology
ISSN: 19485182
reponame:r-INCLIVA. Repositorio Institucional de Producción Científica de INCLIVA
instname:INCLIVA
instname_str INCLIVA
reponame_str r-INCLIVA. Repositorio Institucional de Producción Científica de INCLIVA
collection r-INCLIVA. Repositorio Institucional de Producción Científica de INCLIVA
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,812429

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