Dopamine gene methylation patterns are associated with obesity markers and carbohydrate intake

Introduction: Dopamine (DA) is a neurotransmitter that regulates the rewarding and motivational processes underlying food intake and eating behaviors. This study hy-pothesized associations of DNA methylation signatures at genes modulating DA sign -aling with obesity features, metabolic profiles, and...

Descripción completa

Detalles Bibliográficos
Autores: Ramos-López, O. (Omar)|||/items/40f32b89-391b-4e9a-aca7-948596cbfe94, Riezu-Boj, J.I. (José Ignacio)|||/items/87349e89-7360-4cdd-81be-2e8a6174b5f6, Milagro-Yoldi, F.I. (Fermín Ignacio)|||/items/07cf7af6-1f5f-4720-8c14-5197a7a724eb, Martinez, J.A. (José Alfredo)|||/items/6a3581ea-897b-4439-a95c-19301775e131
Tipo de recurso: artículo
Fecha de publicación:2018
País:España
Institución:Universidad de Navarra
Repositorio:Dadun. Depósito Académico Digital de la Universidad de Navarra
Idioma:inglés
OAI Identifier:oai:dadun.unav.edu:10171/64945
Acceso en línea:https://hdl.handle.net/10171/64945
Access Level:acceso abierto
Palabra clave:Diet
Dopamine
Epigenetics
Obesity
SLC18A1
SLC6A3
id ES_25580fc42871f2b8d6a0cb693e31f37f
oai_identifier_str oai:dadun.unav.edu:10171/64945
network_acronym_str ES
network_name_str España
repository_id_str
spelling Dopamine gene methylation patterns are associated with obesity markers and carbohydrate intakeRamos-López, O. (Omar)|||/items/40f32b89-391b-4e9a-aca7-948596cbfe94Riezu-Boj, J.I. (José Ignacio)|||/items/87349e89-7360-4cdd-81be-2e8a6174b5f6Milagro-Yoldi, F.I. (Fermín Ignacio)|||/items/07cf7af6-1f5f-4720-8c14-5197a7a724ebMartinez, J.A. (José Alfredo)|||/items/6a3581ea-897b-4439-a95c-19301775e131DietDopamineEpigeneticsObesitySLC18A1SLC6A3Introduction: Dopamine (DA) is a neurotransmitter that regulates the rewarding and motivational processes underlying food intake and eating behaviors. This study hy-pothesized associations of DNA methylation signatures at genes modulating DA sign -aling with obesity features, metabolic profiles, and dietary intake.Methods: An adult population within the Methyl Epigenome Network Association project was included (n = 473). DNA methylation levels in white blood cells were measured by microarray (450K). Differentially methylated genes were mapped within the dopaminergic synapse pathway using the KEGG reference database (map04728). Subsequently, network enrichment analyses were run in the pathDIP portal. Associations of methylation patterns with anthropometric markers of general (BMI) and abdominal obesity (waist circumference), the blood metabolic profile, and daily dietary intakes were screened.Results: After applying a correction for multiple comparisons, 12 CpG sites were strongly associated (p <0.0001) with BMI: cg03489495 (ITPR3), cg22851378 (PPP2R2D), cg04021127 (PPP2R2D), cg22441882 (SLC18A1), cg03045635 (DRD5), cg23341970 (ITPR2), cg13051970 (DDC), cg08943004 (SLC6A3), cg20557710 (C ACNA1C), cg24085522 (GNAL), cg16846691 (ITPR2), and cg09691393 (SLC6A3). Moreover, average methylation levels of these genes differed according to the pres -ence or absence of abdominal obesity. Pathway analyses revealed a statistically sig-nificant contribution of the aforementioned genes to dopaminergic synapse transmission (p =4.78E−08). Furthermore,SLC18A1 and SLC6A3 gene methylation signatures correlated with total energy (p <0.001) and carbohydrate (p <0.001) intakes.Conclusions: The results of this investigation reveal that methylation status on DA signaling genes may underlie epigenetic mechanisms contributing to carbohydrate and calorie consumption and fat deposition.Wiley Open AccessDadun. Depósito Académico Digital Universidad de Navarra20222022-12-2120182018-01-0120182018-01-01journal articlehttp://purl.org/coar/resource_type/c_6501info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/10171/64945reponame:Dadun. Depósito Académico Digital de la Universidad de Navarrainstname:Universidad de NavarraInglésengopen accesshttp://purl.org/coar/access_right/c_abf2info:eu-repo/semantics/openAccessoai:dadun.unav.edu:10171/649452026-06-21T12:47:57Z
dc.title.none.fl_str_mv Dopamine gene methylation patterns are associated with obesity markers and carbohydrate intake
title Dopamine gene methylation patterns are associated with obesity markers and carbohydrate intake
spellingShingle Dopamine gene methylation patterns are associated with obesity markers and carbohydrate intake
Ramos-López, O. (Omar)|||/items/40f32b89-391b-4e9a-aca7-948596cbfe94
Diet
Dopamine
Epigenetics
Obesity
SLC18A1
SLC6A3
title_short Dopamine gene methylation patterns are associated with obesity markers and carbohydrate intake
title_full Dopamine gene methylation patterns are associated with obesity markers and carbohydrate intake
title_fullStr Dopamine gene methylation patterns are associated with obesity markers and carbohydrate intake
title_full_unstemmed Dopamine gene methylation patterns are associated with obesity markers and carbohydrate intake
title_sort Dopamine gene methylation patterns are associated with obesity markers and carbohydrate intake
dc.creator.none.fl_str_mv Ramos-López, O. (Omar)|||/items/40f32b89-391b-4e9a-aca7-948596cbfe94
Riezu-Boj, J.I. (José Ignacio)|||/items/87349e89-7360-4cdd-81be-2e8a6174b5f6
Milagro-Yoldi, F.I. (Fermín Ignacio)|||/items/07cf7af6-1f5f-4720-8c14-5197a7a724eb
Martinez, J.A. (José Alfredo)|||/items/6a3581ea-897b-4439-a95c-19301775e131
author Ramos-López, O. (Omar)|||/items/40f32b89-391b-4e9a-aca7-948596cbfe94
author_facet Ramos-López, O. (Omar)|||/items/40f32b89-391b-4e9a-aca7-948596cbfe94
Riezu-Boj, J.I. (José Ignacio)|||/items/87349e89-7360-4cdd-81be-2e8a6174b5f6
Milagro-Yoldi, F.I. (Fermín Ignacio)|||/items/07cf7af6-1f5f-4720-8c14-5197a7a724eb
Martinez, J.A. (José Alfredo)|||/items/6a3581ea-897b-4439-a95c-19301775e131
author_role author
author2 Riezu-Boj, J.I. (José Ignacio)|||/items/87349e89-7360-4cdd-81be-2e8a6174b5f6
Milagro-Yoldi, F.I. (Fermín Ignacio)|||/items/07cf7af6-1f5f-4720-8c14-5197a7a724eb
Martinez, J.A. (José Alfredo)|||/items/6a3581ea-897b-4439-a95c-19301775e131
author2_role author
author
author
dc.contributor.none.fl_str_mv Dadun. Depósito Académico Digital Universidad de Navarra
dc.subject.none.fl_str_mv Diet
Dopamine
Epigenetics
Obesity
SLC18A1
SLC6A3
topic Diet
Dopamine
Epigenetics
Obesity
SLC18A1
SLC6A3
description Introduction: Dopamine (DA) is a neurotransmitter that regulates the rewarding and motivational processes underlying food intake and eating behaviors. This study hy-pothesized associations of DNA methylation signatures at genes modulating DA sign -aling with obesity features, metabolic profiles, and dietary intake.Methods: An adult population within the Methyl Epigenome Network Association project was included (n = 473). DNA methylation levels in white blood cells were measured by microarray (450K). Differentially methylated genes were mapped within the dopaminergic synapse pathway using the KEGG reference database (map04728). Subsequently, network enrichment analyses were run in the pathDIP portal. Associations of methylation patterns with anthropometric markers of general (BMI) and abdominal obesity (waist circumference), the blood metabolic profile, and daily dietary intakes were screened.Results: After applying a correction for multiple comparisons, 12 CpG sites were strongly associated (p <0.0001) with BMI: cg03489495 (ITPR3), cg22851378 (PPP2R2D), cg04021127 (PPP2R2D), cg22441882 (SLC18A1), cg03045635 (DRD5), cg23341970 (ITPR2), cg13051970 (DDC), cg08943004 (SLC6A3), cg20557710 (C ACNA1C), cg24085522 (GNAL), cg16846691 (ITPR2), and cg09691393 (SLC6A3). Moreover, average methylation levels of these genes differed according to the pres -ence or absence of abdominal obesity. Pathway analyses revealed a statistically sig-nificant contribution of the aforementioned genes to dopaminergic synapse transmission (p =4.78E−08). Furthermore,SLC18A1 and SLC6A3 gene methylation signatures correlated with total energy (p <0.001) and carbohydrate (p <0.001) intakes.Conclusions: The results of this investigation reveal that methylation status on DA signaling genes may underlie epigenetic mechanisms contributing to carbohydrate and calorie consumption and fat deposition.
publishDate 2018
dc.date.none.fl_str_mv 2018
2018-01-01
2018
2018-01-01
2022
2022-12-21
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/10171/64945
url https://hdl.handle.net/10171/64945
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Wiley Open Access
publisher.none.fl_str_mv Wiley Open Access
dc.source.none.fl_str_mv reponame:Dadun. Depósito Académico Digital de la Universidad de Navarra
instname:Universidad de Navarra
instname_str Universidad de Navarra
reponame_str Dadun. Depósito Académico Digital de la Universidad de Navarra
collection Dadun. Depósito Académico Digital de la Universidad de Navarra
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869404751641182208
score 15,300719

Similares en LA Referencia