Improving virus production through quasispecies genomic selection and molecular breedings

Virus production still is a challenging issue in antigen manufacture, particularly with slow-growing viruses. Deep-sequencing of genomic regions indicative of efficient replication may be used to identify high-fitness minority individuals suppressed by the ensemble of mutants in a virus quasispecies...

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Detalles Bibliográficos
Autores: Pérez-Rodríguez, Francisco Javier, D'Andrea Rodríguez-Vida, Lucía, Castellarnau Serra, Montserrat de, Costafreda Salvany, M. Isabel (Maria Isabel), Guix Arnau, Susana, Ribes Mora, Enric, Quer, Josep, Gregori Font, Josep, Bosch, Albert, Pintó Solé, Rosa María
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2016
País:España
Institución:Universidad de Barcelona
Repositorio:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/116589
Acceso en línea:https://hdl.handle.net/2445/116589
Access Level:acceso abierto
Palabra clave:Virologia
Espècies (Biologia)
Virology
Species
Descripción
Sumario:Virus production still is a challenging issue in antigen manufacture, particularly with slow-growing viruses. Deep-sequencing of genomic regions indicative of efficient replication may be used to identify high-fitness minority individuals suppressed by the ensemble of mutants in a virus quasispecies. Molecular breeding of quasispecies containing colonizer individuals, under regimes allowing more than one replicative cycle, is a strategy to select the fittest competitors among the colonizers. A slow-growing cell culture-adapted hepatitis A virus strain was employed as a model for this strategy. Using genomic selection in two regions predictive of efficient translation, the internal ribosome entry site and the VP1-coding region, high-fitness minority colonizer individuals were identified in a population adapted to conditions of artificially-induced cellular transcription shut-off. Molecular breeding of this population with a second one, also adapted to transcription shut-off and showing an overall colonizer phenotype, allowed the selection of a fast-growing population of great biotechnological potential.