Gastrointestinal Involvement in Dermatomyositis

Dermatomyositis is a systemic vasculopathy mainly affecting skin, muscle and lung, but may affect the gastrointestinal tract. We aim to describe clinical characteristics of patients with severe gastrointestinal involvement related to dermatomyositis in our center and medical literature. We retrospec...

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Autores: Matas García, Ana, Milisenda, José, Espinosa Garriga, Gerard, Cuatrecasas Freixas, Miriam, Selva O'Callaghan, Albert, Grau Junyent, Josep M. (Josep Maria), Prieto González, Sergio
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2022
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/191015
Acceso en línea:https://hdl.handle.net/2445/191015
Access Level:acceso abierto
Palabra clave:Dermatomiositis
Malalties del tracte gastrointestinal
Motilitat gastrointestinal
Malalties intestinals
Dermatomyositis
Gastrointestinal system diseases
Gastrointestinal motility
Intestinal diseases
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spelling Gastrointestinal Involvement in DermatomyositisMatas García, AnaMilisenda, JoséEspinosa Garriga, GerardCuatrecasas Freixas, MiriamSelva O'Callaghan, AlbertGrau Junyent, Josep M. (Josep Maria)Prieto González, SergioDermatomiositisMalalties del tracte gastrointestinalMotilitat gastrointestinalMalalties intestinalsDermatomyositisGastrointestinal system diseasesGastrointestinal motilityIntestinal diseasesDermatomyositis is a systemic vasculopathy mainly affecting skin, muscle and lung, but may affect the gastrointestinal tract. We aim to describe clinical characteristics of patients with severe gastrointestinal involvement related to dermatomyositis in our center and medical literature. We retrospectively analysed these patients in our center, including cases of erosions/ulcers, perforation or digestive bleeding. Reported cases from April 1990 to April 2021 were reviewed through PubMed and Cochrane. From our cohort (n = 188), only 3 presented gastrointestinal compromise. All were women (10, 46 and 68 years). The initial symptom was abdominal pain and all had ≥2 episodes of digestive bleeding. All died due to complications of gastrointestinal involvement. Available pathological samples showed vascular ectasia. From the literature review (n = 50), 77% were women with a mean age of 49 years and the main symptom was abdominal pain (65%). All presented active muscular and cutaneous involvement at complication diagnosis. Mortality was 41.7%. The underlying lesion was perforation or ulcer (n = 22), intestinal wall thickening (n = 2), macroscopic inflammation (n = 2) or intestinal pneumatosis (n = 15). In 13 cases, vasculitis was described. Gastrointestinal involvement in dermatomyositis denotes severity, so an early intensive treatment is recommended. Pathological findings suggest that the underlying pathophysiological mechanism is a vasculopathy and not a true vasculitis.MDPI2022202220222022info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion11 p.application/pdfhttps://hdl.handle.net/2445/191015Articles publicats en revistes (Medicina)reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésReproducció del document publicat a: https://doi.org/10.3390/diagnostics12051200Diagnostics, 2022, vol. 12, num. 5, p. 1200https://doi.org/10.3390/diagnostics12051200cc-by (c) Matas Garcia, Ana et al., 2022https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:recercat.cat:2445/1910152026-05-29T05:05:01Z
dc.title.none.fl_str_mv Gastrointestinal Involvement in Dermatomyositis
title Gastrointestinal Involvement in Dermatomyositis
spellingShingle Gastrointestinal Involvement in Dermatomyositis
Matas García, Ana
Dermatomiositis
Malalties del tracte gastrointestinal
Motilitat gastrointestinal
Malalties intestinals
Dermatomyositis
Gastrointestinal system diseases
Gastrointestinal motility
Intestinal diseases
title_short Gastrointestinal Involvement in Dermatomyositis
title_full Gastrointestinal Involvement in Dermatomyositis
title_fullStr Gastrointestinal Involvement in Dermatomyositis
title_full_unstemmed Gastrointestinal Involvement in Dermatomyositis
title_sort Gastrointestinal Involvement in Dermatomyositis
dc.creator.none.fl_str_mv Matas García, Ana
Milisenda, José
Espinosa Garriga, Gerard
Cuatrecasas Freixas, Miriam
Selva O'Callaghan, Albert
Grau Junyent, Josep M. (Josep Maria)
Prieto González, Sergio
author Matas García, Ana
author_facet Matas García, Ana
Milisenda, José
Espinosa Garriga, Gerard
Cuatrecasas Freixas, Miriam
Selva O'Callaghan, Albert
Grau Junyent, Josep M. (Josep Maria)
Prieto González, Sergio
author_role author
author2 Milisenda, José
Espinosa Garriga, Gerard
Cuatrecasas Freixas, Miriam
Selva O'Callaghan, Albert
Grau Junyent, Josep M. (Josep Maria)
Prieto González, Sergio
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv Dermatomiositis
Malalties del tracte gastrointestinal
Motilitat gastrointestinal
Malalties intestinals
Dermatomyositis
Gastrointestinal system diseases
Gastrointestinal motility
Intestinal diseases
topic Dermatomiositis
Malalties del tracte gastrointestinal
Motilitat gastrointestinal
Malalties intestinals
Dermatomyositis
Gastrointestinal system diseases
Gastrointestinal motility
Intestinal diseases
description Dermatomyositis is a systemic vasculopathy mainly affecting skin, muscle and lung, but may affect the gastrointestinal tract. We aim to describe clinical characteristics of patients with severe gastrointestinal involvement related to dermatomyositis in our center and medical literature. We retrospectively analysed these patients in our center, including cases of erosions/ulcers, perforation or digestive bleeding. Reported cases from April 1990 to April 2021 were reviewed through PubMed and Cochrane. From our cohort (n = 188), only 3 presented gastrointestinal compromise. All were women (10, 46 and 68 years). The initial symptom was abdominal pain and all had ≥2 episodes of digestive bleeding. All died due to complications of gastrointestinal involvement. Available pathological samples showed vascular ectasia. From the literature review (n = 50), 77% were women with a mean age of 49 years and the main symptom was abdominal pain (65%). All presented active muscular and cutaneous involvement at complication diagnosis. Mortality was 41.7%. The underlying lesion was perforation or ulcer (n = 22), intestinal wall thickening (n = 2), macroscopic inflammation (n = 2) or intestinal pneumatosis (n = 15). In 13 cases, vasculitis was described. Gastrointestinal involvement in dermatomyositis denotes severity, so an early intensive treatment is recommended. Pathological findings suggest that the underlying pathophysiological mechanism is a vasculopathy and not a true vasculitis.
publishDate 2022
dc.date.none.fl_str_mv 2022
2022
2022
2022
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/191015
url https://hdl.handle.net/2445/191015
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.3390/diagnostics12051200
Diagnostics, 2022, vol. 12, num. 5, p. 1200
https://doi.org/10.3390/diagnostics12051200
dc.rights.none.fl_str_mv cc-by (c) Matas Garcia, Ana et al., 2022
https://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc-by (c) Matas Garcia, Ana et al., 2022
https://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 11 p.
application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv Articles publicats en revistes (Medicina)
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,811543

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