Gut microbial dysbiosis after traumatic brain injury modulates the immune response and impairs neurogenesis

Celorrio, M. (Marta)|||/items/1c21ed29-2398-4b36-9da9-ceee1b049605; Abellanas-Sánchez, M.A. (Miguel Ángel)|||/items/007133d0-5288-468d-b322-6dac2e55713e; Rhodes, J. (James)|||/items/2f516455-6d36-4dd7-8692-65e93469628e; Goodwin, V. (Victoria)|||/items/9cf47818-916d-4bc3-9aaf-6cf4b943024b; Moritz, J. (Jennie)|||/items/41e5b6d6-ef64-49ae-a070-7aaadaf69ea9; Vadivelu, S. (Sangeetha)|||/items/8c3d8df8-a865-486a-9a0d-03fda9498bb5; Wang, L. (Leran)|||/items/379528a9-7813-47ed-8673-cc52ee56f80f; Rodgers, R. (Rachel)|||/items/af840211-4eea-48ec-8375-8b598abebe71; Xiao, S. (Sophia)|||/items/7f73dfb6-b0d8-4524-8d1f-ee807863e31c; Anabayan, I. (Ilakkia)|||/items/8479018d-f761-4e8a-b86b-ca5571023b16; Payne, C. (Camryn)|||/items/15670357-f607-47eb-9a8c-2507960d05dc; Perry, A.M. (Alexandra M.)|||/items/3ead2fa5-6f96-4316-98ae-96609540fa43; Baldridge, M.T. (Megan T.)|||/items/009fc443-c0d5-4420-b072-db477c000aa1; Aymerich-Soler, M.S. (María Soledad)|||/items/f65ae32b-d1a8-4fa4-ba9f-b8b10241f470; Steed, A. (Ashley)|||/items/56340a2f-1c43-475a-8098-7d82cb001195; Friess, H. (Helmut)|||/items/7e18c499-9b12-4978-8af5-e6783a789107

Gut microbial dysbiosis after traumatic brain injury modulates the immune response and impairs neurogenesis

The influence of the gut microbiota on traumatic brain injury (TBI) is presently unknown. This knowledge gap is of paramount clinical significance as TBI patients are highly susceptible to alterations in the gut microbiota by antibiotic exposure. Antibiotic-induced gut microbial dysbiosis establishe...

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Autores:	Celorrio, M. (Marta)\|\|\|/items/1c21ed29-2398-4b36-9da9-ceee1b049605, Abellanas-Sánchez, M.A. (Miguel Ángel)\|\|\|/items/007133d0-5288-468d-b322-6dac2e55713e, Rhodes, J. (James)\|\|\|/items/2f516455-6d36-4dd7-8692-65e93469628e, Goodwin, V. (Victoria)\|\|\|/items/9cf47818-916d-4bc3-9aaf-6cf4b943024b, Moritz, J. (Jennie)\|\|\|/items/41e5b6d6-ef64-49ae-a070-7aaadaf69ea9, Vadivelu, S. (Sangeetha)\|\|\|/items/8c3d8df8-a865-486a-9a0d-03fda9498bb5, Wang, L. (Leran)\|\|\|/items/379528a9-7813-47ed-8673-cc52ee56f80f, Rodgers, R. (Rachel)\|\|\|/items/af840211-4eea-48ec-8375-8b598abebe71, Xiao, S. (Sophia)\|\|\|/items/7f73dfb6-b0d8-4524-8d1f-ee807863e31c, Anabayan, I. (Ilakkia)\|\|\|/items/8479018d-f761-4e8a-b86b-ca5571023b16, Payne, C. (Camryn)\|\|\|/items/15670357-f607-47eb-9a8c-2507960d05dc, Perry, A.M. (Alexandra M.)\|\|\|/items/3ead2fa5-6f96-4316-98ae-96609540fa43, Baldridge, M.T. (Megan T.)\|\|\|/items/009fc443-c0d5-4420-b072-db477c000aa1, Aymerich-Soler, M.S. (María Soledad)\|\|\|/items/f65ae32b-d1a8-4fa4-ba9f-b8b10241f470, Steed, A. (Ashley)\|\|\|/items/56340a2f-1c43-475a-8098-7d82cb001195, Friess, H. (Helmut)\|\|\|/items/7e18c499-9b12-4978-8af5-e6783a789107
Tipo de recurso:	artículo
Fecha de publicación:	2021
País:	España
Institución:	Universidad de Navarra
Repositorio:	Dadun. Depósito Académico Digital de la Universidad de Navarra
Idioma:	inglés
OAI Identifier:	oai:dadun.unav.edu:10171/115638
Acceso en línea:	https://hdl.handle.net/10171/115638
Access Level:	acceso abierto
Palabra clave:	Antibiotics Fear conditioning Gut microbial dysbiosis Microglia Monocytes Neurogenesis T cells Traumatic brain injury

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spelling	Gut microbial dysbiosis after traumatic brain injury modulates the immune response and impairs neurogenesisCelorrio, M. (Marta)\|\|\|/items/1c21ed29-2398-4b36-9da9-ceee1b049605Abellanas-Sánchez, M.A. (Miguel Ángel)\|\|\|/items/007133d0-5288-468d-b322-6dac2e55713eRhodes, J. (James)\|\|\|/items/2f516455-6d36-4dd7-8692-65e93469628eGoodwin, V. (Victoria)\|\|\|/items/9cf47818-916d-4bc3-9aaf-6cf4b943024bMoritz, J. (Jennie)\|\|\|/items/41e5b6d6-ef64-49ae-a070-7aaadaf69ea9Vadivelu, S. (Sangeetha)\|\|\|/items/8c3d8df8-a865-486a-9a0d-03fda9498bb5Wang, L. (Leran)\|\|\|/items/379528a9-7813-47ed-8673-cc52ee56f80fRodgers, R. (Rachel)\|\|\|/items/af840211-4eea-48ec-8375-8b598abebe71Xiao, S. (Sophia)\|\|\|/items/7f73dfb6-b0d8-4524-8d1f-ee807863e31cAnabayan, I. (Ilakkia)\|\|\|/items/8479018d-f761-4e8a-b86b-ca5571023b16Payne, C. (Camryn)\|\|\|/items/15670357-f607-47eb-9a8c-2507960d05dcPerry, A.M. (Alexandra M.)\|\|\|/items/3ead2fa5-6f96-4316-98ae-96609540fa43Baldridge, M.T. (Megan T.)\|\|\|/items/009fc443-c0d5-4420-b072-db477c000aa1Aymerich-Soler, M.S. (María Soledad)\|\|\|/items/f65ae32b-d1a8-4fa4-ba9f-b8b10241f470Steed, A. (Ashley)\|\|\|/items/56340a2f-1c43-475a-8098-7d82cb001195Friess, H. (Helmut)\|\|\|/items/7e18c499-9b12-4978-8af5-e6783a789107AntibioticsFear conditioningGut microbial dysbiosisMicrogliaMonocytesNeurogenesisT cellsTraumatic brain injuryThe influence of the gut microbiota on traumatic brain injury (TBI) is presently unknown. This knowledge gap is of paramount clinical significance as TBI patients are highly susceptible to alterations in the gut microbiota by antibiotic exposure. Antibiotic-induced gut microbial dysbiosis established prior to TBI significantly worsened neuronal loss and reduced microglia activation in the injured hippocampus with concomitant changes in fear memory response. Importantly, antibiotic exposure for 1 week after TBI reduced cortical infiltration of Ly6Chigh monocytes, increased microglial pro-inflammatory markers, and decreased T lymphocyte infiltration, which persisted through 1 month post-injury. Moreover, microbial dysbiosis was associated with reduced neurogenesis in the dentate gyrus 1 week after TBI. By 3 months after injury (11 weeks after discontinuation of the antibiotics), we observed increased microglial proliferation, increased hippocampal neuronal loss, and modulation of fear memory response. These data demonstrate that antibiotic-induced gut microbial dysbiosis after TBI impacts neuroinflammation, neurogenesis, and fear memory and implicate gut microbial modulation as a potential therapeutic intervention for TBI.BioMed CentralDadun. Depósito Académico Digital Universidad de Navarra20212021-01-0120212021-01-01journal articlehttp://purl.org/coar/resource_type/c_6501info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/10171/115638reponame:Dadun. Depósito Académico Digital de la Universidad de Navarrainstname:Universidad de NavarraInglésengopen accesshttp://purl.org/coar/access_right/c_abf2info:eu-repo/semantics/openAccessoai:dadun.unav.edu:10171/1156382026-06-21T12:47:57Z
dc.title.none.fl_str_mv	Gut microbial dysbiosis after traumatic brain injury modulates the immune response and impairs neurogenesis
title	Gut microbial dysbiosis after traumatic brain injury modulates the immune response and impairs neurogenesis
spellingShingle	Gut microbial dysbiosis after traumatic brain injury modulates the immune response and impairs neurogenesis Celorrio, M. (Marta)\|\|\|/items/1c21ed29-2398-4b36-9da9-ceee1b049605 Antibiotics Fear conditioning Gut microbial dysbiosis Microglia Monocytes Neurogenesis T cells Traumatic brain injury
title_short	Gut microbial dysbiosis after traumatic brain injury modulates the immune response and impairs neurogenesis
title_full	Gut microbial dysbiosis after traumatic brain injury modulates the immune response and impairs neurogenesis
title_fullStr	Gut microbial dysbiosis after traumatic brain injury modulates the immune response and impairs neurogenesis
title_full_unstemmed	Gut microbial dysbiosis after traumatic brain injury modulates the immune response and impairs neurogenesis
title_sort	Gut microbial dysbiosis after traumatic brain injury modulates the immune response and impairs neurogenesis
dc.creator.none.fl_str_mv	Celorrio, M. (Marta)\|\|\|/items/1c21ed29-2398-4b36-9da9-ceee1b049605 Abellanas-Sánchez, M.A. (Miguel Ángel)\|\|\|/items/007133d0-5288-468d-b322-6dac2e55713e Rhodes, J. (James)\|\|\|/items/2f516455-6d36-4dd7-8692-65e93469628e Goodwin, V. (Victoria)\|\|\|/items/9cf47818-916d-4bc3-9aaf-6cf4b943024b Moritz, J. (Jennie)\|\|\|/items/41e5b6d6-ef64-49ae-a070-7aaadaf69ea9 Vadivelu, S. (Sangeetha)\|\|\|/items/8c3d8df8-a865-486a-9a0d-03fda9498bb5 Wang, L. (Leran)\|\|\|/items/379528a9-7813-47ed-8673-cc52ee56f80f Rodgers, R. (Rachel)\|\|\|/items/af840211-4eea-48ec-8375-8b598abebe71 Xiao, S. (Sophia)\|\|\|/items/7f73dfb6-b0d8-4524-8d1f-ee807863e31c Anabayan, I. (Ilakkia)\|\|\|/items/8479018d-f761-4e8a-b86b-ca5571023b16 Payne, C. (Camryn)\|\|\|/items/15670357-f607-47eb-9a8c-2507960d05dc Perry, A.M. (Alexandra M.)\|\|\|/items/3ead2fa5-6f96-4316-98ae-96609540fa43 Baldridge, M.T. (Megan T.)\|\|\|/items/009fc443-c0d5-4420-b072-db477c000aa1 Aymerich-Soler, M.S. (María Soledad)\|\|\|/items/f65ae32b-d1a8-4fa4-ba9f-b8b10241f470 Steed, A. (Ashley)\|\|\|/items/56340a2f-1c43-475a-8098-7d82cb001195 Friess, H. (Helmut)\|\|\|/items/7e18c499-9b12-4978-8af5-e6783a789107
author	Celorrio, M. (Marta)\|\|\|/items/1c21ed29-2398-4b36-9da9-ceee1b049605
author_facet	Celorrio, M. (Marta)\|\|\|/items/1c21ed29-2398-4b36-9da9-ceee1b049605 Abellanas-Sánchez, M.A. (Miguel Ángel)\|\|\|/items/007133d0-5288-468d-b322-6dac2e55713e Rhodes, J. (James)\|\|\|/items/2f516455-6d36-4dd7-8692-65e93469628e Goodwin, V. (Victoria)\|\|\|/items/9cf47818-916d-4bc3-9aaf-6cf4b943024b Moritz, J. (Jennie)\|\|\|/items/41e5b6d6-ef64-49ae-a070-7aaadaf69ea9 Vadivelu, S. (Sangeetha)\|\|\|/items/8c3d8df8-a865-486a-9a0d-03fda9498bb5 Wang, L. (Leran)\|\|\|/items/379528a9-7813-47ed-8673-cc52ee56f80f Rodgers, R. (Rachel)\|\|\|/items/af840211-4eea-48ec-8375-8b598abebe71 Xiao, S. (Sophia)\|\|\|/items/7f73dfb6-b0d8-4524-8d1f-ee807863e31c Anabayan, I. (Ilakkia)\|\|\|/items/8479018d-f761-4e8a-b86b-ca5571023b16 Payne, C. (Camryn)\|\|\|/items/15670357-f607-47eb-9a8c-2507960d05dc Perry, A.M. (Alexandra M.)\|\|\|/items/3ead2fa5-6f96-4316-98ae-96609540fa43 Baldridge, M.T. (Megan T.)\|\|\|/items/009fc443-c0d5-4420-b072-db477c000aa1 Aymerich-Soler, M.S. (María Soledad)\|\|\|/items/f65ae32b-d1a8-4fa4-ba9f-b8b10241f470 Steed, A. (Ashley)\|\|\|/items/56340a2f-1c43-475a-8098-7d82cb001195 Friess, H. (Helmut)\|\|\|/items/7e18c499-9b12-4978-8af5-e6783a789107
author_role	author
author2	Abellanas-Sánchez, M.A. (Miguel Ángel)\|\|\|/items/007133d0-5288-468d-b322-6dac2e55713e Rhodes, J. (James)\|\|\|/items/2f516455-6d36-4dd7-8692-65e93469628e Goodwin, V. (Victoria)\|\|\|/items/9cf47818-916d-4bc3-9aaf-6cf4b943024b Moritz, J. (Jennie)\|\|\|/items/41e5b6d6-ef64-49ae-a070-7aaadaf69ea9 Vadivelu, S. (Sangeetha)\|\|\|/items/8c3d8df8-a865-486a-9a0d-03fda9498bb5 Wang, L. (Leran)\|\|\|/items/379528a9-7813-47ed-8673-cc52ee56f80f Rodgers, R. (Rachel)\|\|\|/items/af840211-4eea-48ec-8375-8b598abebe71 Xiao, S. (Sophia)\|\|\|/items/7f73dfb6-b0d8-4524-8d1f-ee807863e31c Anabayan, I. (Ilakkia)\|\|\|/items/8479018d-f761-4e8a-b86b-ca5571023b16 Payne, C. (Camryn)\|\|\|/items/15670357-f607-47eb-9a8c-2507960d05dc Perry, A.M. (Alexandra M.)\|\|\|/items/3ead2fa5-6f96-4316-98ae-96609540fa43 Baldridge, M.T. (Megan T.)\|\|\|/items/009fc443-c0d5-4420-b072-db477c000aa1 Aymerich-Soler, M.S. (María Soledad)\|\|\|/items/f65ae32b-d1a8-4fa4-ba9f-b8b10241f470 Steed, A. (Ashley)\|\|\|/items/56340a2f-1c43-475a-8098-7d82cb001195 Friess, H. (Helmut)\|\|\|/items/7e18c499-9b12-4978-8af5-e6783a789107
author2_role	author author author author author author author author author author author author author author author
dc.contributor.none.fl_str_mv	Dadun. Depósito Académico Digital Universidad de Navarra
dc.subject.none.fl_str_mv	Antibiotics Fear conditioning Gut microbial dysbiosis Microglia Monocytes Neurogenesis T cells Traumatic brain injury
topic	Antibiotics Fear conditioning Gut microbial dysbiosis Microglia Monocytes Neurogenesis T cells Traumatic brain injury
description	The influence of the gut microbiota on traumatic brain injury (TBI) is presently unknown. This knowledge gap is of paramount clinical significance as TBI patients are highly susceptible to alterations in the gut microbiota by antibiotic exposure. Antibiotic-induced gut microbial dysbiosis established prior to TBI significantly worsened neuronal loss and reduced microglia activation in the injured hippocampus with concomitant changes in fear memory response. Importantly, antibiotic exposure for 1 week after TBI reduced cortical infiltration of Ly6Chigh monocytes, increased microglial pro-inflammatory markers, and decreased T lymphocyte infiltration, which persisted through 1 month post-injury. Moreover, microbial dysbiosis was associated with reduced neurogenesis in the dentate gyrus 1 week after TBI. By 3 months after injury (11 weeks after discontinuation of the antibiotics), we observed increased microglial proliferation, increased hippocampal neuronal loss, and modulation of fear memory response. These data demonstrate that antibiotic-induced gut microbial dysbiosis after TBI impacts neuroinflammation, neurogenesis, and fear memory and implicate gut microbial modulation as a potential therapeutic intervention for TBI.
publishDate	2021
dc.date.none.fl_str_mv	2021 2021-01-01 2021 2021-01-01
dc.type.none.fl_str_mv	journal article http://purl.org/coar/resource_type/c_6501
dc.type.openaire.fl_str_mv	info:eu-repo/semantics/article
format	article
dc.identifier.none.fl_str_mv	https://hdl.handle.net/10171/115638
url	https://hdl.handle.net/10171/115638
dc.language.none.fl_str_mv	Inglés eng
language_invalid_str_mv	Inglés
language	eng
dc.rights.none.fl_str_mv	open access http://purl.org/coar/access_right/c_abf2
dc.rights.openaire.fl_str_mv	info:eu-repo/semantics/openAccess
rights_invalid_str_mv	open access http://purl.org/coar/access_right/c_abf2
eu_rights_str_mv	openAccess
dc.format.none.fl_str_mv	application/pdf
dc.publisher.none.fl_str_mv	BioMed Central
publisher.none.fl_str_mv	BioMed Central
dc.source.none.fl_str_mv	reponame:Dadun. Depósito Académico Digital de la Universidad de Navarra instname:Universidad de Navarra
instname_str	Universidad de Navarra
reponame_str	Dadun. Depósito Académico Digital de la Universidad de Navarra
collection	Dadun. Depósito Académico Digital de la Universidad de Navarra
repository.name.fl_str_mv
repository.mail.fl_str_mv
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Gut microbial dysbiosis after traumatic brain injury modulates the immune response and impairs neurogenesis

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