Overeating, caloric restriction and mammographic density in Spanish women. DDM-Spain study

Objectives: Mammographic density (MD) is a strong risk factor for breast cancer. The present study evaluates the association between relative caloric intake and MD in Spanish women. Study design: We conducted a cross-sectional study in which 3517 women were recruited from seven breast cancer screeni...

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Autores: Del Pozo MDP, Castelló A, Vidal C, Salas-Trejo D, Sánchez-Contador C, Pedraz-Pingarrón C, Moreo P, Santamariña C, Ederra M, Llobet R, Vioque J, Pérez-Gómez B, Pollán M, Lope V
Formato: artículo
Estado:Versión publicada
Fecha de publicación:2018
País:España
Recursos:Instituto de Investigación Biomédica y Sanitaria de Alicante (ISABIAL)
Repositorio:r-ISABIAL. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica y Sanitaria de Alicante
OAI Identifier:oai:isabial.fundanetsuite.com:p2553
Acesso em linha:https://isabial.portalinvestigacion.com/publicaciones2553
Access Level:acceso abierto
Palavra-chave:Breast density
Calories
Energy intake
Caloric intake
Basal metabolic rate
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spelling Overeating, caloric restriction and mammographic density in Spanish women. DDM-Spain studyDel Pozo MDPCastelló AVidal CSalas-Trejo DSánchez-Contador CPedraz-Pingarrón CMoreo PSantamariña CEderra MLlobet RVioque JPérez-Gómez BPollán MLope VBreast densityCaloriesEnergy intakeCaloric intakeBasal metabolic rateObjectives: Mammographic density (MD) is a strong risk factor for breast cancer. The present study evaluates the association between relative caloric intake and MD in Spanish women. Study design: We conducted a cross-sectional study in which 3517 women were recruited from seven breast cancer screening centers. MD was measured by an experienced radiologist using craniocaudal mammography and Boyd's semi-quantitative scale. Information was collected through an epidemiological survey. Predicted calories were calculated using linear regression models, including the basal metabolic rate and physical activity as explanatory variables. Overeating and caloric restriction were defined taking into account the 99% confidence interval of the predicted value. Odds ratios (OR) and 95% confidence intervals (95%CI) were estimated using center-specific mixed ordinal logistic regression models, adjusted for age, menopausal status, body mass index, parity, tobacco use, family history of breast cancer, previous biopsies, age at menarche and adherence to a Western diet. Main outcome measure: Mammographic density. Results: Those women with an excessive caloric intake ( > 40% above predicted) presented higher MD (OR = 1.41, 95%CI = 0.97-2.03; p = 0.070). For every 20% increase in relative caloric consumption the probability of having higher MD increased by 5% (OR = 1.05, 95%CI = 0.98-1.14; p = 0.178), not observing differences between the categories of explanatory variables. Caloric restriction was not associated with MD in our study. Conclusions: This is the first study exploring the association between MD and the effect of caloric deficit or excessive caloric consumption according to the energy requirements of each woman. Although caloric restriction does not seem to affect breast density, a caloric intake above predicted levels seems to increase this phenotype.ELSEVIER IRELAND LTD2018info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://isabial.portalinvestigacion.com/publicaciones2553MATURITASISSN: 03785122ISSNe: 18734111reponame:r-ISABIAL. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica y Sanitaria de Alicanteinstname:Instituto de Investigación Biomédica y Sanitaria de Alicante (ISABIAL)Inglésinfo:eu-repo/semantics/openAccessoai:isabial.fundanetsuite.com:p25532026-06-12T10:20:37Z
dc.title.none.fl_str_mv Overeating, caloric restriction and mammographic density in Spanish women. DDM-Spain study
title Overeating, caloric restriction and mammographic density in Spanish women. DDM-Spain study
spellingShingle Overeating, caloric restriction and mammographic density in Spanish women. DDM-Spain study
Del Pozo MDP
Breast density
Calories
Energy intake
Caloric intake
Basal metabolic rate
title_short Overeating, caloric restriction and mammographic density in Spanish women. DDM-Spain study
title_full Overeating, caloric restriction and mammographic density in Spanish women. DDM-Spain study
title_fullStr Overeating, caloric restriction and mammographic density in Spanish women. DDM-Spain study
title_full_unstemmed Overeating, caloric restriction and mammographic density in Spanish women. DDM-Spain study
title_sort Overeating, caloric restriction and mammographic density in Spanish women. DDM-Spain study
dc.creator.none.fl_str_mv Del Pozo MDP
Castelló A
Vidal C
Salas-Trejo D
Sánchez-Contador C
Pedraz-Pingarrón C
Moreo P
Santamariña C
Ederra M
Llobet R
Vioque J
Pérez-Gómez B
Pollán M
Lope V
author Del Pozo MDP
author_facet Del Pozo MDP
Castelló A
Vidal C
Salas-Trejo D
Sánchez-Contador C
Pedraz-Pingarrón C
Moreo P
Santamariña C
Ederra M
Llobet R
Vioque J
Pérez-Gómez B
Pollán M
Lope V
author_role author
author2 Castelló A
Vidal C
Salas-Trejo D
Sánchez-Contador C
Pedraz-Pingarrón C
Moreo P
Santamariña C
Ederra M
Llobet R
Vioque J
Pérez-Gómez B
Pollán M
Lope V
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Breast density
Calories
Energy intake
Caloric intake
Basal metabolic rate
topic Breast density
Calories
Energy intake
Caloric intake
Basal metabolic rate
description Objectives: Mammographic density (MD) is a strong risk factor for breast cancer. The present study evaluates the association between relative caloric intake and MD in Spanish women. Study design: We conducted a cross-sectional study in which 3517 women were recruited from seven breast cancer screening centers. MD was measured by an experienced radiologist using craniocaudal mammography and Boyd's semi-quantitative scale. Information was collected through an epidemiological survey. Predicted calories were calculated using linear regression models, including the basal metabolic rate and physical activity as explanatory variables. Overeating and caloric restriction were defined taking into account the 99% confidence interval of the predicted value. Odds ratios (OR) and 95% confidence intervals (95%CI) were estimated using center-specific mixed ordinal logistic regression models, adjusted for age, menopausal status, body mass index, parity, tobacco use, family history of breast cancer, previous biopsies, age at menarche and adherence to a Western diet. Main outcome measure: Mammographic density. Results: Those women with an excessive caloric intake ( > 40% above predicted) presented higher MD (OR = 1.41, 95%CI = 0.97-2.03; p = 0.070). For every 20% increase in relative caloric consumption the probability of having higher MD increased by 5% (OR = 1.05, 95%CI = 0.98-1.14; p = 0.178), not observing differences between the categories of explanatory variables. Caloric restriction was not associated with MD in our study. Conclusions: This is the first study exploring the association between MD and the effect of caloric deficit or excessive caloric consumption according to the energy requirements of each woman. Although caloric restriction does not seem to affect breast density, a caloric intake above predicted levels seems to increase this phenotype.
publishDate 2018
dc.date.none.fl_str_mv 2018
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://isabial.portalinvestigacion.com/publicaciones2553
url https://isabial.portalinvestigacion.com/publicaciones2553
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv ELSEVIER IRELAND LTD
publisher.none.fl_str_mv ELSEVIER IRELAND LTD
dc.source.none.fl_str_mv MATURITAS
ISSN: 03785122
ISSNe: 18734111
reponame:r-ISABIAL. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica y Sanitaria de Alicante
instname:Instituto de Investigación Biomédica y Sanitaria de Alicante (ISABIAL)
instname_str Instituto de Investigación Biomédica y Sanitaria de Alicante (ISABIAL)
reponame_str r-ISABIAL. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica y Sanitaria de Alicante
collection r-ISABIAL. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica y Sanitaria de Alicante
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,198674

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