The relationship between urinary total polyphenols and the frailty phenotype in a community-dwelling older population: the InCHIANTI study.

Background. Frailty, an age-related state of increased vulnerability, is associated with a higher risk of multiple adverse events. Studies have suggested that the quality of dietary intake may affect the development of frailty. We hypothesized that frailty in older subjects would be associated with...

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Autores: Urpí Sardà, Mireia, Andrés Lacueva, Ma. Cristina, Rabassa Bonet, Montserrat, Ruggiero, Carmelinda, Zamora-Ros, Raul, Bandinelli, Stefania, Ferrucci, Luigi, Cherubini, Antonio
Tipo de recurso: artículo
Estado:Versión aceptada para publicación
Fecha de publicación:2015
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/164088
Acceso en línea:https://hdl.handle.net/2445/164088
Access Level:acceso abierto
Palabra clave:Persones grans
Nutrició
Cuina mediterrània
Fragilitat
Marcadors bioquímics
Polifenols
Orina
Epidemiologia
Fenotip
Itàlia
Older people
Nutrition
Mediterranean cooking
Brittleness
Biochemical markers
Polyphenols
Urine
Epidemiology
Phenotype
Italy
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spelling The relationship between urinary total polyphenols and the frailty phenotype in a community-dwelling older population: the InCHIANTI study.Urpí Sardà, MireiaAndrés Lacueva, Ma. CristinaRabassa Bonet, MontserratRuggiero, CarmelindaZamora-Ros, RaulBandinelli, StefaniaFerrucci, LuigiCherubini, AntonioPersones gransNutricióCuina mediterràniaFragilitatMarcadors bioquímicsPolifenolsOrinaEpidemiologiaFenotipItàliaOlder peopleNutritionMediterranean cookingBrittlenessBiochemical markersPolyphenolsUrineEpidemiologyPhenotypeItalyBackground. Frailty, an age-related state of increased vulnerability, is associated with a higher risk of multiple adverse events. Studies have suggested that the quality of dietary intake may affect the development of frailty. We hypothesized that frailty in older subjects would be associated with dietary total polyphenols (DTP) intake and its biomarker, urinary total polyphenols (UTP). Methods. The Invecchiare in Chianti (InCHIANTI) Study is a prospective cohort study set in the Chianti area (Italy). We used data at baseline from 811 participants aged 65 years and older. UTP was determined using the Folin-Ciocalteu assay after solid-phase extraction. DTP was estimated using a validated Food Frequency Questionnaire and our own polyphenol database. The frailty, prefrailty, and nonfrailty states were defined according to the Fried and colleagues' criteria. Multinomial logistic regressions adjusted for potential confounders were used to assess the relationship between polyphenols and frailty. Results. Both DTP and UTP concentrations progressively decrease from nonfrail to frail participants. Participants in the highest UTP tertile compared to those in the lowest tertile were significantly less likely to be both frail (odds ratio [OR] = 0.36 [0.14-0.88], p = .025) and prefrail (OR = 0.64 [0.42-0.98], p = .038). Exhaustion and slowness were the only individual frailty criteria significantly associated with UTP tertiles. No significant association was observed between frailty and DTP, after adjustment for covariates. Conclusions. High concentrations of UTP were associated with lower prevalence of frailty and prefrailty in an older community-dwelling population. A polyphenol-rich diet may protect against frailty in older persons. Our findings should be confirmed in longitudinal studies.Gerontological Society of America2020202020152020info:eu-repo/semantics/articleinfo:eu-repo/semantics/acceptedVersion7 p.application/pdfhttps://hdl.handle.net/2445/164088Articles publicats en revistes (Nutrició, Ciències de l'Alimentació i Gastronomia)reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésVersió postprint del document publicat a: https://doi.org/10.1093/gerona/glv026Journals of Gerontology Series A: Biomedical Sciences and Medical Sciences, 2015, vol. 70, num. 9, p. 1141-1147https://doi.org/10.1093/gerona/glv026(c) Urpí Sardà, Mireia et al., 2015info:eu-repo/semantics/openAccessoai:recercat.cat:2445/1640882026-05-29T05:05:01Z
dc.title.none.fl_str_mv The relationship between urinary total polyphenols and the frailty phenotype in a community-dwelling older population: the InCHIANTI study.
title The relationship between urinary total polyphenols and the frailty phenotype in a community-dwelling older population: the InCHIANTI study.
spellingShingle The relationship between urinary total polyphenols and the frailty phenotype in a community-dwelling older population: the InCHIANTI study.
Urpí Sardà, Mireia
Persones grans
Nutrició
Cuina mediterrània
Fragilitat
Marcadors bioquímics
Polifenols
Orina
Epidemiologia
Fenotip
Itàlia
Older people
Nutrition
Mediterranean cooking
Brittleness
Biochemical markers
Polyphenols
Urine
Epidemiology
Phenotype
Italy
title_short The relationship between urinary total polyphenols and the frailty phenotype in a community-dwelling older population: the InCHIANTI study.
title_full The relationship between urinary total polyphenols and the frailty phenotype in a community-dwelling older population: the InCHIANTI study.
title_fullStr The relationship between urinary total polyphenols and the frailty phenotype in a community-dwelling older population: the InCHIANTI study.
title_full_unstemmed The relationship between urinary total polyphenols and the frailty phenotype in a community-dwelling older population: the InCHIANTI study.
title_sort The relationship between urinary total polyphenols and the frailty phenotype in a community-dwelling older population: the InCHIANTI study.
dc.creator.none.fl_str_mv Urpí Sardà, Mireia
Andrés Lacueva, Ma. Cristina
Rabassa Bonet, Montserrat
Ruggiero, Carmelinda
Zamora-Ros, Raul
Bandinelli, Stefania
Ferrucci, Luigi
Cherubini, Antonio
author Urpí Sardà, Mireia
author_facet Urpí Sardà, Mireia
Andrés Lacueva, Ma. Cristina
Rabassa Bonet, Montserrat
Ruggiero, Carmelinda
Zamora-Ros, Raul
Bandinelli, Stefania
Ferrucci, Luigi
Cherubini, Antonio
author_role author
author2 Andrés Lacueva, Ma. Cristina
Rabassa Bonet, Montserrat
Ruggiero, Carmelinda
Zamora-Ros, Raul
Bandinelli, Stefania
Ferrucci, Luigi
Cherubini, Antonio
author2_role author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Persones grans
Nutrició
Cuina mediterrània
Fragilitat
Marcadors bioquímics
Polifenols
Orina
Epidemiologia
Fenotip
Itàlia
Older people
Nutrition
Mediterranean cooking
Brittleness
Biochemical markers
Polyphenols
Urine
Epidemiology
Phenotype
Italy
topic Persones grans
Nutrició
Cuina mediterrània
Fragilitat
Marcadors bioquímics
Polifenols
Orina
Epidemiologia
Fenotip
Itàlia
Older people
Nutrition
Mediterranean cooking
Brittleness
Biochemical markers
Polyphenols
Urine
Epidemiology
Phenotype
Italy
description Background. Frailty, an age-related state of increased vulnerability, is associated with a higher risk of multiple adverse events. Studies have suggested that the quality of dietary intake may affect the development of frailty. We hypothesized that frailty in older subjects would be associated with dietary total polyphenols (DTP) intake and its biomarker, urinary total polyphenols (UTP). Methods. The Invecchiare in Chianti (InCHIANTI) Study is a prospective cohort study set in the Chianti area (Italy). We used data at baseline from 811 participants aged 65 years and older. UTP was determined using the Folin-Ciocalteu assay after solid-phase extraction. DTP was estimated using a validated Food Frequency Questionnaire and our own polyphenol database. The frailty, prefrailty, and nonfrailty states were defined according to the Fried and colleagues' criteria. Multinomial logistic regressions adjusted for potential confounders were used to assess the relationship between polyphenols and frailty. Results. Both DTP and UTP concentrations progressively decrease from nonfrail to frail participants. Participants in the highest UTP tertile compared to those in the lowest tertile were significantly less likely to be both frail (odds ratio [OR] = 0.36 [0.14-0.88], p = .025) and prefrail (OR = 0.64 [0.42-0.98], p = .038). Exhaustion and slowness were the only individual frailty criteria significantly associated with UTP tertiles. No significant association was observed between frailty and DTP, after adjustment for covariates. Conclusions. High concentrations of UTP were associated with lower prevalence of frailty and prefrailty in an older community-dwelling population. A polyphenol-rich diet may protect against frailty in older persons. Our findings should be confirmed in longitudinal studies.
publishDate 2015
dc.date.none.fl_str_mv 2015
2020
2020
2020
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/acceptedVersion
format article
status_str acceptedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/164088
url https://hdl.handle.net/2445/164088
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Versió postprint del document publicat a: https://doi.org/10.1093/gerona/glv026
Journals of Gerontology Series A: Biomedical Sciences and Medical Sciences, 2015, vol. 70, num. 9, p. 1141-1147
https://doi.org/10.1093/gerona/glv026
dc.rights.none.fl_str_mv (c) Urpí Sardà, Mireia et al., 2015
info:eu-repo/semantics/openAccess
rights_invalid_str_mv (c) Urpí Sardà, Mireia et al., 2015
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 7 p.
application/pdf
dc.publisher.none.fl_str_mv Gerontological Society of America
publisher.none.fl_str_mv Gerontological Society of America
dc.source.none.fl_str_mv Articles publicats en revistes (Nutrició, Ciències de l'Alimentació i Gastronomia)
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,812429

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