Blood vessels are in control : vasculature regulates the neural niche in cranial sensory ganglia
Cranial sensory ganglia are groups of neurons located in the head of chordates outside the central nervous system that allow individuals to sense and perceive information from the outer world. The regulation of neural proliferation and differentiation is key for cranial ganglia formation and functio...
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| Tipo de recurso: | tesis doctoral |
| Estado: | Versión publicada |
| Fecha de publicación: | 2019 |
| País: | España |
| Institución: | CBUC, CESCA |
| Repositorio: | TDR. Tesis Doctorales en Red |
| OAI Identifier: | oai:www.tdx.cat:10803/668054 |
| Acceso en línea: | http://hdl.handle.net/10803/668054 |
| Access Level: | acceso abierto |
| Palabra clave: | Neurovascular Cranial ganglia Dll4/Notch Cytonemes Bood flow Ganglis granials Flux sanguini 616.8 |
| Sumario: | Cranial sensory ganglia are groups of neurons located in the head of chordates outside the central nervous system that allow individuals to sense and perceive information from the outer world. The regulation of neural proliferation and differentiation is key for cranial ganglia formation and functioning. This control is carried out by signals provided by their niche. Blood vessels have emerged as key components in the adult neural stem cell niche. However, the putative function of vasculature on neural behaviour has yet not been studied in the peripheral nervous system. In the present work, I have described the anatomical relationship of cranial sensory ganglia with vasculature during their development, focusing in the statoacoustic ganglion and using zebrafish as a model system. Secondly, I have demonstrated that two independent signalling mechanisms exist from vasculature to the developing sensory neurons. Early in development, endothelial cells maintain neural cells’ quiescence via Dll4/Notch1 signalling and cytoneme contacts. Later, blood flow onset produces transcriptional changes in neural cells related to oxygen sensing and is required for the differentiation of sensory neurons. |
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