Microfluidic device on fused silica for raman spectroscopy of liquid samples

Water testing is becoming increasingly important due to dangerous phenomena such as Harmful Algal Blooms (HABs). Commonly, the content of a water sample is measured for the detection, monitoring and control of these events. Raman spectroscopy is a technique for the molecular characterization of mate...

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Autores: Goméz Galdós, Celia, Pérez Asensio, Andrea|||0009-0009-9565-0746, Fernández Manteca, María Gabriela, García García, Borja|||0009-0006-0686-483X, Algorri Genaro, José Francisco|||0000-0002-2654-583X, López Higuera, José Miguel|||0000-0002-8615-8487, Rodríguez Cobo, Luis|||0000-0002-2068-2956, Cobo García, Adolfo|||0000-0003-1498-9238
Tipo de recurso: artículo
Fecha de publicación:2025
País:España
Institución:Universidad de Cantabria (UC)
Repositorio:UCrea Repositorio Abierto de la Universidad de Cantabria
Idioma:inglés
OAI Identifier:oai:repositorio.unican.es:10902/36379
Acceso en línea:https://hdl.handle.net/10902/36379
Access Level:acceso abierto
Palabra clave:Microfluidic
ULAE
Raman spectroscopy
Cyanobacteria
Continuous flow
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spelling Microfluidic device on fused silica for raman spectroscopy of liquid samplesGoméz Galdós, CeliaPérez Asensio, Andrea|||0009-0009-9565-0746Fernández Manteca, María GabrielaGarcía García, Borja|||0009-0006-0686-483XAlgorri Genaro, José Francisco|||0000-0002-2654-583XLópez Higuera, José Miguel|||0000-0002-8615-8487Rodríguez Cobo, Luis|||0000-0002-2068-2956Cobo García, Adolfo|||0000-0003-1498-9238MicrofluidicULAERaman spectroscopyCyanobacteriaContinuous flowWater testing is becoming increasingly important due to dangerous phenomena such as Harmful Algal Blooms (HABs). Commonly, the content of a water sample is measured for the detection, monitoring and control of these events. Raman spectroscopy is a technique for the molecular characterization of materials in solid, liquid or gaseous form, which makes it an attractive method for analysing materials’ components. However, Raman scattering is a weak optical process and requires an accurate system for detection. In our work, we present, from design to fabrication, a microfluidic device on fused silica adapted to optimise the Raman spectrum of liquid samples when using a Raman probe. The device features a portable design for rapid on-site continuous flow measurements avoiding the use of large, costly and complex laboratory equipment. The main manufacturing technique used was ultrafast laser-assisted etching (ULAE). Finally, the effectiveness of the microfluidic device was demonstrated by comparing the Raman spectra of a known species of cyanobacteria with those obtained using other conventional substrates in laboratory analysis. The results demonstrate that the microfluidic device, under continuous flow conditions, exhibited a lower standard deviation of the Raman signal, reduced background noise and avoided signal variations caused by sample drying in static measurements.This work was supported by the R+D projects INNVAL23/10 and INNVAL24-28, and PREVAL23/05 funded by Instituto de Investigación Marqués de Valdecilla (IDIVAL); C.G.-G. acknowledges the University of Cantabria for the support provided through the Concepción Arenal PhD research grant; J.F.A. acknowledges RYC2022-035279-I, funded by MCIN/AEI/10.13039/501100011033 and FSE+; TED2021-130378BC21, funded by MCIN/AEI/10.13039/501100011033 and European Union NextGenerationEU/PRTR; PID2022-137269OB-C22, funded by MCIN/AEI/10.13039/501100011033 and FEDER, UE; Plan Nacional de I+D+i and Instituto de Salud Carlos III (ISCIII), Subdirección General de Redes y Centros de Investigación Cooperativa, Ministerio de Ciencia, Innovación y Universidades, through CIBER-BBN (CB16/01/00430).MDPIUniversidad de Cantabria20252025-03-06journal articlehttp://purl.org/coar/resource_type/c_6501NAhttp://purl.org/coar/version/c_be7fb7dd8ff6fe43info:eu-repo/semantics/articlehttps://hdl.handle.net/10902/36379Biosensors, 2025, 15(3), 172reponame:UCrea Repositorio Abierto de la Universidad de Cantabriainstname:Universidad de Cantabria (UC)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2Attribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:repositorio.unican.es:10902/363792026-06-02T12:39:31Z
dc.title.none.fl_str_mv Microfluidic device on fused silica for raman spectroscopy of liquid samples
title Microfluidic device on fused silica for raman spectroscopy of liquid samples
spellingShingle Microfluidic device on fused silica for raman spectroscopy of liquid samples
Goméz Galdós, Celia
Microfluidic
ULAE
Raman spectroscopy
Cyanobacteria
Continuous flow
title_short Microfluidic device on fused silica for raman spectroscopy of liquid samples
title_full Microfluidic device on fused silica for raman spectroscopy of liquid samples
title_fullStr Microfluidic device on fused silica for raman spectroscopy of liquid samples
title_full_unstemmed Microfluidic device on fused silica for raman spectroscopy of liquid samples
title_sort Microfluidic device on fused silica for raman spectroscopy of liquid samples
dc.creator.none.fl_str_mv Goméz Galdós, Celia
Pérez Asensio, Andrea|||0009-0009-9565-0746
Fernández Manteca, María Gabriela
García García, Borja|||0009-0006-0686-483X
Algorri Genaro, José Francisco|||0000-0002-2654-583X
López Higuera, José Miguel|||0000-0002-8615-8487
Rodríguez Cobo, Luis|||0000-0002-2068-2956
Cobo García, Adolfo|||0000-0003-1498-9238
author Goméz Galdós, Celia
author_facet Goméz Galdós, Celia
Pérez Asensio, Andrea|||0009-0009-9565-0746
Fernández Manteca, María Gabriela
García García, Borja|||0009-0006-0686-483X
Algorri Genaro, José Francisco|||0000-0002-2654-583X
López Higuera, José Miguel|||0000-0002-8615-8487
Rodríguez Cobo, Luis|||0000-0002-2068-2956
Cobo García, Adolfo|||0000-0003-1498-9238
author_role author
author2 Pérez Asensio, Andrea|||0009-0009-9565-0746
Fernández Manteca, María Gabriela
García García, Borja|||0009-0006-0686-483X
Algorri Genaro, José Francisco|||0000-0002-2654-583X
López Higuera, José Miguel|||0000-0002-8615-8487
Rodríguez Cobo, Luis|||0000-0002-2068-2956
Cobo García, Adolfo|||0000-0003-1498-9238
author2_role author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidad de Cantabria
dc.subject.none.fl_str_mv Microfluidic
ULAE
Raman spectroscopy
Cyanobacteria
Continuous flow
topic Microfluidic
ULAE
Raman spectroscopy
Cyanobacteria
Continuous flow
description Water testing is becoming increasingly important due to dangerous phenomena such as Harmful Algal Blooms (HABs). Commonly, the content of a water sample is measured for the detection, monitoring and control of these events. Raman spectroscopy is a technique for the molecular characterization of materials in solid, liquid or gaseous form, which makes it an attractive method for analysing materials’ components. However, Raman scattering is a weak optical process and requires an accurate system for detection. In our work, we present, from design to fabrication, a microfluidic device on fused silica adapted to optimise the Raman spectrum of liquid samples when using a Raman probe. The device features a portable design for rapid on-site continuous flow measurements avoiding the use of large, costly and complex laboratory equipment. The main manufacturing technique used was ultrafast laser-assisted etching (ULAE). Finally, the effectiveness of the microfluidic device was demonstrated by comparing the Raman spectra of a known species of cyanobacteria with those obtained using other conventional substrates in laboratory analysis. The results demonstrate that the microfluidic device, under continuous flow conditions, exhibited a lower standard deviation of the Raman signal, reduced background noise and avoided signal variations caused by sample drying in static measurements.
publishDate 2025
dc.date.none.fl_str_mv 2025
2025-03-06
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
NA
http://purl.org/coar/version/c_be7fb7dd8ff6fe43
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/10902/36379
url https://hdl.handle.net/10902/36379
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv Biosensors, 2025, 15(3), 172
reponame:UCrea Repositorio Abierto de la Universidad de Cantabria
instname:Universidad de Cantabria (UC)
instname_str Universidad de Cantabria (UC)
reponame_str UCrea Repositorio Abierto de la Universidad de Cantabria
collection UCrea Repositorio Abierto de la Universidad de Cantabria
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,812429

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