Influence of congenital human cytomegalovirus infection and the NKG2C genotype on NK-cell subset distribution in children

Human cytomegalovirus (HCMV) has been reported to reshape the NK-cell receptor (NKR) distribution, promoting an expansion of CD94/NKG2C+ NK and T cells. The role of NK cells in congenital HCMV infection is ill-defined. Here we studied the expression of NKR (i.e., NKG2C, NKG2A, LILRB1, CD161) and the...

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Autores: Noyola DE, Fortuny C, Muntasell A, Noguera-Julian A, Muñoz-Almagro C, Alarcón A, Juncosa T, Moraru M, Vilches C, López-Botet M
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2012
País:España
Institución:Fundació Sant Joan de Déu
Repositorio:r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
OAI Identifier:oai:fsjd.fundanetsuite.com:p304
Acceso en línea:https://fsjd.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=304
Access Level:acceso abierto
Palabra clave:Congenital infection
Cytomegalovirus
NK cells
NKG2C
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spelling Influence of congenital human cytomegalovirus infection and the NKG2C genotype on NK-cell subset distribution in childrenNoyola DEFortuny CMuntasell ANoguera-Julian AMuñoz-Almagro CAlarcón AJuncosa TMoraru MVilches CLópez-Botet MCongenital infectionCytomegalovirusNK cellsNKG2CHuman cytomegalovirus (HCMV) has been reported to reshape the NK-cell receptor (NKR) distribution, promoting an expansion of CD94/NKG2C+ NK and T cells. The role of NK cells in congenital HCMV infection is ill-defined. Here we studied the expression of NKR (i.e., NKG2C, NKG2A, LILRB1, CD161) and the frequency of the NKG2C gene deletion in children with past congenital infection, both symptomatic (n = 15) and asymptomatic (n = 11), including as controls children with postnatal infection (n = 11) and noninfected (n = 20). The expansion of NKG2C+ NK cells in HCMV-infected individuals appeared particularly marked and was associated with an increased number of LILRB1+ NK cells in cases with symptomatic congenital infection. Increased numbers of NKG2C+, NKG2A+, and CD161+ T cells were also associated to HCMV infection. The NKG2C deletion frequency was comparable in children with congenital HCMV infection and controls. Remarkably, the homozygous NKG2C+/+ genotype appeared associated with increased absolute numbers of NKG2C+ NK cells. Moreover, HCMV-infected NKG2C+/+ children displayed higher absolute numbers of NKG2A+ and total NK cells than NKG2C+/- individuals. Our study provides novel insights on the impact of HCMV infection on the homeostasis of the NK-cell compartment in children, revealing a modulatory influence of NKG2C copy number.WILEY2012info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://fsjd.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=304EUROPEAN JOURNAL OF IMMUNOLOGYISSN: 00142980ISSNe: 15214141reponame:r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déuinstname:Fundació Sant Joan de DéuInglésinfo:eu-repo/semantics/openAccessoai:fsjd.fundanetsuite.com:p3042026-05-27T12:37:41Z
dc.title.none.fl_str_mv Influence of congenital human cytomegalovirus infection and the NKG2C genotype on NK-cell subset distribution in children
title Influence of congenital human cytomegalovirus infection and the NKG2C genotype on NK-cell subset distribution in children
spellingShingle Influence of congenital human cytomegalovirus infection and the NKG2C genotype on NK-cell subset distribution in children
Noyola DE
Congenital infection
Cytomegalovirus
NK cells
NKG2C
title_short Influence of congenital human cytomegalovirus infection and the NKG2C genotype on NK-cell subset distribution in children
title_full Influence of congenital human cytomegalovirus infection and the NKG2C genotype on NK-cell subset distribution in children
title_fullStr Influence of congenital human cytomegalovirus infection and the NKG2C genotype on NK-cell subset distribution in children
title_full_unstemmed Influence of congenital human cytomegalovirus infection and the NKG2C genotype on NK-cell subset distribution in children
title_sort Influence of congenital human cytomegalovirus infection and the NKG2C genotype on NK-cell subset distribution in children
dc.creator.none.fl_str_mv Noyola DE
Fortuny C
Muntasell A
Noguera-Julian A
Muñoz-Almagro C
Alarcón A
Juncosa T
Moraru M
Vilches C
López-Botet M
author Noyola DE
author_facet Noyola DE
Fortuny C
Muntasell A
Noguera-Julian A
Muñoz-Almagro C
Alarcón A
Juncosa T
Moraru M
Vilches C
López-Botet M
author_role author
author2 Fortuny C
Muntasell A
Noguera-Julian A
Muñoz-Almagro C
Alarcón A
Juncosa T
Moraru M
Vilches C
López-Botet M
author2_role author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Congenital infection
Cytomegalovirus
NK cells
NKG2C
topic Congenital infection
Cytomegalovirus
NK cells
NKG2C
description Human cytomegalovirus (HCMV) has been reported to reshape the NK-cell receptor (NKR) distribution, promoting an expansion of CD94/NKG2C+ NK and T cells. The role of NK cells in congenital HCMV infection is ill-defined. Here we studied the expression of NKR (i.e., NKG2C, NKG2A, LILRB1, CD161) and the frequency of the NKG2C gene deletion in children with past congenital infection, both symptomatic (n = 15) and asymptomatic (n = 11), including as controls children with postnatal infection (n = 11) and noninfected (n = 20). The expansion of NKG2C+ NK cells in HCMV-infected individuals appeared particularly marked and was associated with an increased number of LILRB1+ NK cells in cases with symptomatic congenital infection. Increased numbers of NKG2C+, NKG2A+, and CD161+ T cells were also associated to HCMV infection. The NKG2C deletion frequency was comparable in children with congenital HCMV infection and controls. Remarkably, the homozygous NKG2C+/+ genotype appeared associated with increased absolute numbers of NKG2C+ NK cells. Moreover, HCMV-infected NKG2C+/+ children displayed higher absolute numbers of NKG2A+ and total NK cells than NKG2C+/- individuals. Our study provides novel insights on the impact of HCMV infection on the homeostasis of the NK-cell compartment in children, revealing a modulatory influence of NKG2C copy number.
publishDate 2012
dc.date.none.fl_str_mv 2012
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://fsjd.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=304
url https://fsjd.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=304
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv WILEY
publisher.none.fl_str_mv WILEY
dc.source.none.fl_str_mv EUROPEAN JOURNAL OF IMMUNOLOGY
ISSN: 00142980
ISSNe: 15214141
reponame:r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
instname:Fundació Sant Joan de Déu
instname_str Fundació Sant Joan de Déu
reponame_str r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
collection r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
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