A Receptor of the Immunoglobulin Superfamily Regulates Adaptive Thermogenesis

Exquisite regulation of energy homeostasis protects from nutrient deprivation but causes metabolic dysfunction upon nutrient excess. In human and murine adipose tissue, the accumulation of ligands of the receptor for advanced glycation end products (RAGE) accompanies obesity, implicating this recept...

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Detalles Bibliográficos
Autores: Hurtado del Pozo, Carmen, Ruiz, Henry, Arivazhagan, Lakshmi, Aranda Gómez, Juan Francisco, Shim, Cynthia, Daya, Peter, Derk, Julia, MacLean, Michael, He, Meilun, Frye, Laura, Randall, Friedline, Hye, Lim Noh, Kim, Jason, Friedman, Richard, Ramasamy, Ravichandran, Schmidt, Ann Marie
Tipo de recurso: artículo
Fecha de publicación:2019
País:España
Institución:Universidad Complutense de Madrid (UCM)
Repositorio:Docta Complutense
Idioma:inglés
OAI Identifier:oai:docta.ucm.es:20.500.14352/95020
Acceso en línea:https://hdl.handle.net/20.500.14352/95020
Access Level:acceso abierto
Palabra clave:611.018.26
Adaptive thermogenesis
Adipocyte
Adipose tissue
Cold tolerance
Obesity
Protein kinase A
Receptor for advanced glycation end products
RAGE
Signal transduction
Advanced glycation end products
Bioquímica (Biología)
2403 Bioquímica
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oai_identifier_str oai:docta.ucm.es:20.500.14352/95020
network_acronym_str ES
network_name_str España
repository_id_str
spelling A Receptor of the Immunoglobulin Superfamily Regulates Adaptive ThermogenesisHurtado del Pozo, CarmenRuiz, HenryArivazhagan, LakshmiAranda Gómez, Juan FranciscoShim, CynthiaDaya, PeterDerk, JuliaMacLean, MichaelHe, MeilunFrye, LauraRandall, FriedlineHye, Lim NohKim, JasonFriedman, RichardRamasamy, RavichandranSchmidt, Ann Marie611.018.26Adaptive thermogenesisAdipocyteAdipose tissueCold toleranceObesityProtein kinase AReceptor for advanced glycation end productsRAGESignal transductionAdvanced glycation end productsBioquímica (Biología)2403 BioquímicaExquisite regulation of energy homeostasis protects from nutrient deprivation but causes metabolic dysfunction upon nutrient excess. In human and murine adipose tissue, the accumulation of ligands of the receptor for advanced glycation end products (RAGE) accompanies obesity, implicating this receptor in energy metabolism. Here, we demonstrate that mice bearing global- or adipocyte-specific deletion of Ager, the gene encoding RAGE, display superior metabolic recovery after fasting, a cold challenge, or high-fat feeding. The RAGE-dependent mechanisms were traced to suppression of protein kinase A (PKA)-mediated phosphorylation of its key targets, hormone-sensitive lipase and p38 mitogen-activated protein kinase, upon β-adrenergic receptor stimulation—processes that dampen the expression and activity of uncoupling protein 1 (UCP1) and thermogenic programs. This work identifies the innate role of RAGE as a key node in the immunometabolic networks that control responses to nutrient supply and cold challenges, and it unveils opportunities to harness energy expenditure in environmental and metabolic stress.Cell PressElsevierUniversidad Complutense de Madrid20192019-01-0120192019-01-01journal articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/20.500.14352/95020reponame:Docta Complutenseinstname:Universidad Complutense de Madrid (UCM)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2Attribution-NonCommercial-NoDerivatives 4.0 Internationalhttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:docta.ucm.es:20.500.14352/950202026-06-02T12:44:21Z
dc.title.none.fl_str_mv A Receptor of the Immunoglobulin Superfamily Regulates Adaptive Thermogenesis
title A Receptor of the Immunoglobulin Superfamily Regulates Adaptive Thermogenesis
spellingShingle A Receptor of the Immunoglobulin Superfamily Regulates Adaptive Thermogenesis
Hurtado del Pozo, Carmen
611.018.26
Adaptive thermogenesis
Adipocyte
Adipose tissue
Cold tolerance
Obesity
Protein kinase A
Receptor for advanced glycation end products
RAGE
Signal transduction
Advanced glycation end products
Bioquímica (Biología)
2403 Bioquímica
title_short A Receptor of the Immunoglobulin Superfamily Regulates Adaptive Thermogenesis
title_full A Receptor of the Immunoglobulin Superfamily Regulates Adaptive Thermogenesis
title_fullStr A Receptor of the Immunoglobulin Superfamily Regulates Adaptive Thermogenesis
title_full_unstemmed A Receptor of the Immunoglobulin Superfamily Regulates Adaptive Thermogenesis
title_sort A Receptor of the Immunoglobulin Superfamily Regulates Adaptive Thermogenesis
dc.creator.none.fl_str_mv Hurtado del Pozo, Carmen
Ruiz, Henry
Arivazhagan, Lakshmi
Aranda Gómez, Juan Francisco
Shim, Cynthia
Daya, Peter
Derk, Julia
MacLean, Michael
He, Meilun
Frye, Laura
Randall, Friedline
Hye, Lim Noh
Kim, Jason
Friedman, Richard
Ramasamy, Ravichandran
Schmidt, Ann Marie
author Hurtado del Pozo, Carmen
author_facet Hurtado del Pozo, Carmen
Ruiz, Henry
Arivazhagan, Lakshmi
Aranda Gómez, Juan Francisco
Shim, Cynthia
Daya, Peter
Derk, Julia
MacLean, Michael
He, Meilun
Frye, Laura
Randall, Friedline
Hye, Lim Noh
Kim, Jason
Friedman, Richard
Ramasamy, Ravichandran
Schmidt, Ann Marie
author_role author
author2 Ruiz, Henry
Arivazhagan, Lakshmi
Aranda Gómez, Juan Francisco
Shim, Cynthia
Daya, Peter
Derk, Julia
MacLean, Michael
He, Meilun
Frye, Laura
Randall, Friedline
Hye, Lim Noh
Kim, Jason
Friedman, Richard
Ramasamy, Ravichandran
Schmidt, Ann Marie
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidad Complutense de Madrid
dc.subject.none.fl_str_mv 611.018.26
Adaptive thermogenesis
Adipocyte
Adipose tissue
Cold tolerance
Obesity
Protein kinase A
Receptor for advanced glycation end products
RAGE
Signal transduction
Advanced glycation end products
Bioquímica (Biología)
2403 Bioquímica
topic 611.018.26
Adaptive thermogenesis
Adipocyte
Adipose tissue
Cold tolerance
Obesity
Protein kinase A
Receptor for advanced glycation end products
RAGE
Signal transduction
Advanced glycation end products
Bioquímica (Biología)
2403 Bioquímica
description Exquisite regulation of energy homeostasis protects from nutrient deprivation but causes metabolic dysfunction upon nutrient excess. In human and murine adipose tissue, the accumulation of ligands of the receptor for advanced glycation end products (RAGE) accompanies obesity, implicating this receptor in energy metabolism. Here, we demonstrate that mice bearing global- or adipocyte-specific deletion of Ager, the gene encoding RAGE, display superior metabolic recovery after fasting, a cold challenge, or high-fat feeding. The RAGE-dependent mechanisms were traced to suppression of protein kinase A (PKA)-mediated phosphorylation of its key targets, hormone-sensitive lipase and p38 mitogen-activated protein kinase, upon β-adrenergic receptor stimulation—processes that dampen the expression and activity of uncoupling protein 1 (UCP1) and thermogenic programs. This work identifies the innate role of RAGE as a key node in the immunometabolic networks that control responses to nutrient supply and cold challenges, and it unveils opportunities to harness energy expenditure in environmental and metabolic stress.
publishDate 2019
dc.date.none.fl_str_mv 2019
2019-01-01
2019
2019-01-01
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/20.500.14352/95020
url https://hdl.handle.net/20.500.14352/95020
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial-NoDerivatives 4.0 International
http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial-NoDerivatives 4.0 International
http://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Cell Press
Elsevier
publisher.none.fl_str_mv Cell Press
Elsevier
dc.source.none.fl_str_mv reponame:Docta Complutense
instname:Universidad Complutense de Madrid (UCM)
instname_str Universidad Complutense de Madrid (UCM)
reponame_str Docta Complutense
collection Docta Complutense
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869404673232863232
score 15,300719

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