Alternative Anaphylactic Routes: The Potential Role of Macrophages.

Anaphylaxis is an acute, life-threatening, multisystem syndrome resulting from the sudden release of mediators from effector cells. There are two potential pathways for anaphylaxis. The first one, IgE-dependent anaphylaxis, is induced by antigen (Ag) cross-linking of Ag-specific IgE bound to the hig...

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Detalhes bibliográficos
Autores: Rosace, Domenico, Chivato, Tomas, Fernández, Tahia D, Corbí, Angel L
Formato: artículo
Fecha de publicación:2017
País:España
Recursos:Instituto de Salud Carlos III (ISCIII)
Repositorio:Repisalud
Idioma:inglés
OAI Identifier:oai:repisalud.isciii.es:20.500.12105/17309
Acesso em linha:http://hdl.handle.net/20.500.12105/17309
Access Level:acceso abierto
Palavra-chave:IgE
IgG
anaphylaxis
macrophages
serotonin
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repository_id_str
spelling Alternative Anaphylactic Routes: The Potential Role of Macrophages.Rosace, DomenicoChivato, TomasFernández, Tahia DCorbí, Angel LIgEIgGanaphylaxismacrophagesserotoninAnaphylaxis is an acute, life-threatening, multisystem syndrome resulting from the sudden release of mediators from effector cells. There are two potential pathways for anaphylaxis. The first one, IgE-dependent anaphylaxis, is induced by antigen (Ag) cross-linking of Ag-specific IgE bound to the high-affinity IgE receptor (FcεRI) on mast cells and basophils. The second one, IgG-dependent anaphylaxis is induced by Ag cross-linking of Ag-specific IgG bound to IgG receptors (FcγRI, FcγRIIA, FcγRIIB, FcγRIIC, and FcγRIIIA) on macrophages, neutrophils, and basophils. Macrophages exhibit a huge functional plasticity and are capable of exerting their scavenging, bactericidal, and regulatory functions under a wide variety of tissue conditions. Herein, we will review their potential role in the triggering and development of anaphylaxis. Thereby, macrophages, among other immune cells, play a role in both anaphylactic pathways (1) by responding to anaphylactic mediators secreted by mast cells after specific IgE cross-linking or (2) by acting as effector cells in the anaphylactic response mediated by IgG. In this review, we will go over the cellular and molecular mechanisms that take place in the above-mentioned anaphylactic pathways and will discuss the clinical implications in human allergic reactions.20242024-01-2320172017-05-0820172017-05-08research articlehttp://purl.org/coar/resource_type/c_2df8fbb1VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articlehttp://hdl.handle.net/20.500.12105/17309reponame:Repisaludinstname:Instituto de Salud Carlos III (ISCIII)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2Attribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:repisalud.isciii.es:20.500.12105/173092026-06-12T12:43:37Z
dc.title.none.fl_str_mv Alternative Anaphylactic Routes: The Potential Role of Macrophages.
title Alternative Anaphylactic Routes: The Potential Role of Macrophages.
spellingShingle Alternative Anaphylactic Routes: The Potential Role of Macrophages.
Rosace, Domenico
IgE
IgG
anaphylaxis
macrophages
serotonin
title_short Alternative Anaphylactic Routes: The Potential Role of Macrophages.
title_full Alternative Anaphylactic Routes: The Potential Role of Macrophages.
title_fullStr Alternative Anaphylactic Routes: The Potential Role of Macrophages.
title_full_unstemmed Alternative Anaphylactic Routes: The Potential Role of Macrophages.
title_sort Alternative Anaphylactic Routes: The Potential Role of Macrophages.
dc.creator.none.fl_str_mv Rosace, Domenico
Chivato, Tomas
Fernández, Tahia D
Corbí, Angel L
author Rosace, Domenico
author_facet Rosace, Domenico
Chivato, Tomas
Fernández, Tahia D
Corbí, Angel L
author_role author
author2 Chivato, Tomas
Fernández, Tahia D
Corbí, Angel L
author2_role author
author
author
dc.contributor.none.fl_str_mv
dc.subject.none.fl_str_mv IgE
IgG
anaphylaxis
macrophages
serotonin
topic IgE
IgG
anaphylaxis
macrophages
serotonin
description Anaphylaxis is an acute, life-threatening, multisystem syndrome resulting from the sudden release of mediators from effector cells. There are two potential pathways for anaphylaxis. The first one, IgE-dependent anaphylaxis, is induced by antigen (Ag) cross-linking of Ag-specific IgE bound to the high-affinity IgE receptor (FcεRI) on mast cells and basophils. The second one, IgG-dependent anaphylaxis is induced by Ag cross-linking of Ag-specific IgG bound to IgG receptors (FcγRI, FcγRIIA, FcγRIIB, FcγRIIC, and FcγRIIIA) on macrophages, neutrophils, and basophils. Macrophages exhibit a huge functional plasticity and are capable of exerting their scavenging, bactericidal, and regulatory functions under a wide variety of tissue conditions. Herein, we will review their potential role in the triggering and development of anaphylaxis. Thereby, macrophages, among other immune cells, play a role in both anaphylactic pathways (1) by responding to anaphylactic mediators secreted by mast cells after specific IgE cross-linking or (2) by acting as effector cells in the anaphylactic response mediated by IgG. In this review, we will go over the cellular and molecular mechanisms that take place in the above-mentioned anaphylactic pathways and will discuss the clinical implications in human allergic reactions.
publishDate 2017
dc.date.none.fl_str_mv 2017
2017-05-08
2017
2017-05-08
2024
2024-01-23
dc.type.none.fl_str_mv research article
http://purl.org/coar/resource_type/c_2df8fbb1
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/20.500.12105/17309
url http://hdl.handle.net/20.500.12105/17309
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.source.none.fl_str_mv reponame:Repisalud
instname:Instituto de Salud Carlos III (ISCIII)
instname_str Instituto de Salud Carlos III (ISCIII)
reponame_str Repisalud
collection Repisalud
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,812429

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