Improved prognostic stratification with the FIGO 2023 endometrial cancer staging system. A multicenter Spanish cohort study.

To evaluate the impact of applying the FIGO 2023 staging system compared with FIGO 2009 in a real-world cohort of patients with early-stage endometrial cancer who underwent surgery. This multicenter retrospective cohort study included patients with apparent early-stage endometrial cancer diagnosed b...

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Autores: Veiga, Nadia, Padilla Iserte, Pablo, Oliver, Reyes, Arencibia, Octavio, Díaz Feijoo, Berta, Gil Moreno, Antonio, Coronado, Pluvio J., Martín Salamanca, María Belén, Pantoja Garrido, Manuel, Marcos Sanmartin, Josefa, Gilabert Estellés, Juan, Lorenzo, Cristina, Cazorla, Eduardo, Cabezas, Elena, Roldán Rivas, Fernando, Rodríguez Hernández, José Ramón, Álvarez, Sara, Sánchez, Lourdes, Enguita German, Mónica, Muruzábal, Juan Carlos, SEGO Spain GOG Group
Formato: artículo
Estado:Versión aceptada para publicación
Fecha de publicación:2026
País:España
Recursos:Universidad de Barcelona
Repositorio:Dipòsit Digital de la UB
OAI Identifier:oai:dnet:ubarcelona__::807ac8e1d0750787fbe0cd8760e31196
Acesso em linha:https://hdl.handle.net/2445/228553
Access Level:acceso embargado
Palavra-chave:Càncer d'endometri
Endoscòpia
Càncer de mama
Endometrial cancer
Endoscopy
Breast cancer
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spelling Improved prognostic stratification with the FIGO 2023 endometrial cancer staging system. A multicenter Spanish cohort study.Veiga, Nadia Padilla Iserte, Pablo Oliver, ReyesArencibia, Octavio Díaz Feijoo, BertaGil Moreno, Antonio Coronado, Pluvio J. Martín Salamanca, María BelénPantoja Garrido, Manuel Marcos Sanmartin, JosefaGilabert Estellés, Juan Lorenzo, Cristina Cazorla, EduardoCabezas, ElenaRoldán Rivas, Fernando Rodríguez Hernández, José RamónÁlvarez, Sara Sánchez, LourdesEnguita German, Mónica Muruzábal, Juan CarlosSEGO Spain GOG GroupCàncer d'endometriEndoscòpiaCàncer de mamaEndometrial cancerEndoscopyBreast cancerTo evaluate the impact of applying the FIGO 2023 staging system compared with FIGO 2009 in a real-world cohort of patients with early-stage endometrial cancer who underwent surgery. This multicenter retrospective cohort study included patients with apparent early-stage endometrial cancer diagnosed between 2000 and 2020 across 18 Spanish centers. All patients underwent primary surgery and were classified according to both FIGO 2009 and FIGO 2023 criteria. Stage migration was assessed, and the characteristics of newly defined subgroups were described. Survival outcomes, including overall survival (OS) and progression-free survival (PFS), were compared between classifications. A total of 4566 patients were included. Application of the FIGO 2023 system resulted in stage migration in 909 patients (19.9%) compared with FIGO 2009. The FIGO 2023 system showed a higher 5-year OS for Stage I patients than the 2009 classification (91.3% vs. 88.2%). Within the new substages, 5-year OS was 93.9% in Stage IA1 and 91.9% in Stage IA2, and Stage IA3 demonstrated distinct survival outcomes. Overall survival for Stage III remained comparable between classifications, although outcomes varied across subcategories. In a simplified classification (Stages I-III), the FIGO 2023 system showed improved prognostic discrimination for both PFS and OS according to Harrell's C-index. The FIGO 2023 staging system leads to substantial reclassification of early-stage endometrial cancer patients and introduces new prognostic subgroups. This increased granularity improves prognostic stratification and may support individualized treatment decisions, even when molecular testing is limited.John Wiley & Sons Ltd2026info:eu-repo/semantics/articleinfo:eu-repo/semantics/acceptedVersionapplication/pdfhttps://hdl.handle.net/2445/228553Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer)reponame:Dipòsit Digital de la UBinstname:Universidad de BarcelonaInglésVersió postprint del document publicat a: https://doi.org/10.1002/ijgo.70951International Journal of Gynecology and Obstetricshttps://doi.org/10.1002/ijgo.70951(c) International Federation of Gynecology and Obstetrics, 2026info:eu-repo/semantics/embargoedAccessoai:dnet:ubarcelona__::807ac8e1d0750787fbe0cd8760e311962026-05-27T06:46:51Z
dc.title.none.fl_str_mv Improved prognostic stratification with the FIGO 2023 endometrial cancer staging system. A multicenter Spanish cohort study.
title Improved prognostic stratification with the FIGO 2023 endometrial cancer staging system. A multicenter Spanish cohort study.
spellingShingle Improved prognostic stratification with the FIGO 2023 endometrial cancer staging system. A multicenter Spanish cohort study.
Veiga, Nadia
Càncer d'endometri
Endoscòpia
Càncer de mama
Endometrial cancer
Endoscopy
Breast cancer
title_short Improved prognostic stratification with the FIGO 2023 endometrial cancer staging system. A multicenter Spanish cohort study.
title_full Improved prognostic stratification with the FIGO 2023 endometrial cancer staging system. A multicenter Spanish cohort study.
title_fullStr Improved prognostic stratification with the FIGO 2023 endometrial cancer staging system. A multicenter Spanish cohort study.
title_full_unstemmed Improved prognostic stratification with the FIGO 2023 endometrial cancer staging system. A multicenter Spanish cohort study.
title_sort Improved prognostic stratification with the FIGO 2023 endometrial cancer staging system. A multicenter Spanish cohort study.
dc.creator.none.fl_str_mv Veiga, Nadia
Padilla Iserte, Pablo
Oliver, Reyes
Arencibia, Octavio
Díaz Feijoo, Berta
Gil Moreno, Antonio
Coronado, Pluvio J.
Martín Salamanca, María Belén
Pantoja Garrido, Manuel
Marcos Sanmartin, Josefa
Gilabert Estellés, Juan
Lorenzo, Cristina
Cazorla, Eduardo
Cabezas, Elena
Roldán Rivas, Fernando
Rodríguez Hernández, José Ramón
Álvarez, Sara
Sánchez, Lourdes
Enguita German, Mónica
Muruzábal, Juan Carlos
SEGO Spain GOG Group
author Veiga, Nadia
author_facet Veiga, Nadia
Padilla Iserte, Pablo
Oliver, Reyes
Arencibia, Octavio
Díaz Feijoo, Berta
Gil Moreno, Antonio
Coronado, Pluvio J.
Martín Salamanca, María Belén
Pantoja Garrido, Manuel
Marcos Sanmartin, Josefa
Gilabert Estellés, Juan
Lorenzo, Cristina
Cazorla, Eduardo
Cabezas, Elena
Roldán Rivas, Fernando
Rodríguez Hernández, José Ramón
Álvarez, Sara
Sánchez, Lourdes
Enguita German, Mónica
Muruzábal, Juan Carlos
SEGO Spain GOG Group
author_role author
author2 Padilla Iserte, Pablo
Oliver, Reyes
Arencibia, Octavio
Díaz Feijoo, Berta
Gil Moreno, Antonio
Coronado, Pluvio J.
Martín Salamanca, María Belén
Pantoja Garrido, Manuel
Marcos Sanmartin, Josefa
Gilabert Estellés, Juan
Lorenzo, Cristina
Cazorla, Eduardo
Cabezas, Elena
Roldán Rivas, Fernando
Rodríguez Hernández, José Ramón
Álvarez, Sara
Sánchez, Lourdes
Enguita German, Mónica
Muruzábal, Juan Carlos
SEGO Spain GOG Group
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Càncer d'endometri
Endoscòpia
Càncer de mama
Endometrial cancer
Endoscopy
Breast cancer
topic Càncer d'endometri
Endoscòpia
Càncer de mama
Endometrial cancer
Endoscopy
Breast cancer
description To evaluate the impact of applying the FIGO 2023 staging system compared with FIGO 2009 in a real-world cohort of patients with early-stage endometrial cancer who underwent surgery. This multicenter retrospective cohort study included patients with apparent early-stage endometrial cancer diagnosed between 2000 and 2020 across 18 Spanish centers. All patients underwent primary surgery and were classified according to both FIGO 2009 and FIGO 2023 criteria. Stage migration was assessed, and the characteristics of newly defined subgroups were described. Survival outcomes, including overall survival (OS) and progression-free survival (PFS), were compared between classifications. A total of 4566 patients were included. Application of the FIGO 2023 system resulted in stage migration in 909 patients (19.9%) compared with FIGO 2009. The FIGO 2023 system showed a higher 5-year OS for Stage I patients than the 2009 classification (91.3% vs. 88.2%). Within the new substages, 5-year OS was 93.9% in Stage IA1 and 91.9% in Stage IA2, and Stage IA3 demonstrated distinct survival outcomes. Overall survival for Stage III remained comparable between classifications, although outcomes varied across subcategories. In a simplified classification (Stages I-III), the FIGO 2023 system showed improved prognostic discrimination for both PFS and OS according to Harrell's C-index. The FIGO 2023 staging system leads to substantial reclassification of early-stage endometrial cancer patients and introduces new prognostic subgroups. This increased granularity improves prognostic stratification and may support individualized treatment decisions, even when molecular testing is limited.
publishDate 2026
dc.date.none.fl_str_mv 2026
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/acceptedVersion
format article
status_str acceptedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/228553
url https://hdl.handle.net/2445/228553
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Versió postprint del document publicat a: https://doi.org/10.1002/ijgo.70951
International Journal of Gynecology and Obstetrics
https://doi.org/10.1002/ijgo.70951
dc.rights.none.fl_str_mv (c) International Federation of Gynecology and Obstetrics, 2026
info:eu-repo/semantics/embargoedAccess
rights_invalid_str_mv (c) International Federation of Gynecology and Obstetrics, 2026
eu_rights_str_mv embargoedAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv John Wiley & Sons Ltd
publisher.none.fl_str_mv John Wiley & Sons Ltd
dc.source.none.fl_str_mv Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer)
reponame:Dipòsit Digital de la UB
instname:Universidad de Barcelona
instname_str Universidad de Barcelona
reponame_str Dipòsit Digital de la UB
collection Dipòsit Digital de la UB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.812429

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