Clinical Features, Neuropsychology and Neuroimaging in Bipolar and Borderline Personality Disorder

Background: Bipolar Disorder (BD) and Borderline Personality Disorder (BPD) have clinically been evolving as separate disorders, though there is still debate on the nosological valence of both conditions, their interaction in terms of co-morbidity or disorder spectrum and their distinct pathophysiol...

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Authors: Massó Rodriguez, Anna, Hogg, Bridget|||0000-0002-2405-0593, Gardoki-Souto, Itxaso|||0000-0002-0775-1275, Valiente Gomez, Alicia|||0000-0003-0220-2397, Trabsa, Amira|||0000-0002-8669-0676, Mosquera, Dolores, García-Estela, Aitana|||0000-0001-8529-544X, Colom, Francesc|||0000-0002-9516-9030, Pérez Solà, Víctor|||0000-0002-5825-2337, Padberg, Frank|||0000-0001-7638-8310, Moreno Alcázar, Ana|||0000-0002-3392-5590, Amann, Benedikt L.|||0000-0002-4407-1519
Format: article
Publication Date:2021
Country:España
Institution:Universitat Autònoma de Barcelona
Repository:Dipòsit Digital de Documents de la UAB
Language:English
OAI Identifier:oai:ddd.uab.cat:256412
Online Access:https://ddd.uab.cat/record/256412
https://dx.doi.org/urn:doi:10.3389/fpsyt.2021.681876
Access Level:Open access
Keyword:Bipolar disorder
Borderline personality disorder
Clinical features
Cognitive functions
Neuroimaging
Affective continuum
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network_name_str España
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dc.title.none.fl_str_mv Clinical Features, Neuropsychology and Neuroimaging in Bipolar and Borderline Personality Disorder
A Systematic Review of Cross-Diagnostic Studies
title Clinical Features, Neuropsychology and Neuroimaging in Bipolar and Borderline Personality Disorder
spellingShingle Clinical Features, Neuropsychology and Neuroimaging in Bipolar and Borderline Personality Disorder
Massó Rodriguez, Anna
Bipolar disorder
Borderline personality disorder
Clinical features
Cognitive functions
Neuroimaging
Affective continuum
title_short Clinical Features, Neuropsychology and Neuroimaging in Bipolar and Borderline Personality Disorder
title_full Clinical Features, Neuropsychology and Neuroimaging in Bipolar and Borderline Personality Disorder
title_fullStr Clinical Features, Neuropsychology and Neuroimaging in Bipolar and Borderline Personality Disorder
title_full_unstemmed Clinical Features, Neuropsychology and Neuroimaging in Bipolar and Borderline Personality Disorder
title_sort Clinical Features, Neuropsychology and Neuroimaging in Bipolar and Borderline Personality Disorder
dc.creator.none.fl_str_mv Massó Rodriguez, Anna
Hogg, Bridget|||0000-0002-2405-0593
Gardoki-Souto, Itxaso|||0000-0002-0775-1275
Valiente Gomez, Alicia|||0000-0003-0220-2397
Trabsa, Amira|||0000-0002-8669-0676
Mosquera, Dolores
García-Estela, Aitana|||0000-0001-8529-544X
Colom, Francesc|||0000-0002-9516-9030
Pérez Solà, Víctor|||0000-0002-5825-2337
Padberg, Frank|||0000-0001-7638-8310
Moreno Alcázar, Ana|||0000-0002-3392-5590
Amann, Benedikt L.|||0000-0002-4407-1519
author Massó Rodriguez, Anna
author_facet Massó Rodriguez, Anna
Hogg, Bridget|||0000-0002-2405-0593
Gardoki-Souto, Itxaso|||0000-0002-0775-1275
Valiente Gomez, Alicia|||0000-0003-0220-2397
Trabsa, Amira|||0000-0002-8669-0676
Mosquera, Dolores
García-Estela, Aitana|||0000-0001-8529-544X
Colom, Francesc|||0000-0002-9516-9030
Pérez Solà, Víctor|||0000-0002-5825-2337
Padberg, Frank|||0000-0001-7638-8310
Moreno Alcázar, Ana|||0000-0002-3392-5590
Amann, Benedikt L.|||0000-0002-4407-1519
author_role author
author2 Hogg, Bridget|||0000-0002-2405-0593
Gardoki-Souto, Itxaso|||0000-0002-0775-1275
Valiente Gomez, Alicia|||0000-0003-0220-2397
Trabsa, Amira|||0000-0002-8669-0676
Mosquera, Dolores
García-Estela, Aitana|||0000-0001-8529-544X
Colom, Francesc|||0000-0002-9516-9030
Pérez Solà, Víctor|||0000-0002-5825-2337
Padberg, Frank|||0000-0001-7638-8310
Moreno Alcázar, Ana|||0000-0002-3392-5590
Amann, Benedikt L.|||0000-0002-4407-1519
author2_role author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Bipolar disorder
Borderline personality disorder
Clinical features
Cognitive functions
Neuroimaging
Affective continuum
topic Bipolar disorder
Borderline personality disorder
Clinical features
Cognitive functions
Neuroimaging
Affective continuum
description Background: Bipolar Disorder (BD) and Borderline Personality Disorder (BPD) have clinically been evolving as separate disorders, though there is still debate on the nosological valence of both conditions, their interaction in terms of co-morbidity or disorder spectrum and their distinct pathophysiology. Objective: The objective of this review is to summarize evidence regarding clinical features, neuropsychological performance and neuroimaging findings from cross-diagnostic studies comparing BD and BPD, to further caracterize their complex interplay. Methods: Using PubMed, PsycINFO and TripDataBase, we conducted a systematic literature search based on PRISMA guidelines of studies published from January 1980 to September 2019 which directly compared BD and BPD. Results: A total of 28 studies comparing BD and BPD were included: 19 compared clinical features, 6 neuropsychological performance and three neuroimaging abnormalities. Depressive symptoms have an earlier onset in BPD than BD. BD patients present more mixed or manic symptoms, with BD-I differing from BPD in manic phases. BPD patients show more negative attitudes toward others and self, more conflictive interpersonal relationships, and more maladaptive regulation strategies in affective instability with separate pathways. Impulsivity seems more a trait in BPD rather than a state as in BD. Otherwise, BD and BPD overlap in depressive and anxious symptoms, dysphoria, various abnormal temperamental traits, suicidal ideation, and childhood trauma. Both disorders differ and share deficits in neuropsychological and neuroimaging findings. Conclusion: Clinical data provide evidence of overlapping features in both disorders, with most of those shared symptoms being more persistent and intense in BPD. Thus, categorical classifications should be compared to dimensional approaches in transdiagnostic studies investigating BPD features in BD regarding their respective explanatory power for individual trajectories. Systematic Review Registration: The search strategy was pre-registered in PROSPERO: CRD42018100268.
publishDate 2021
dc.date.none.fl_str_mv 2
2021-01-01
2021
2021-01-01
dc.type.none.fl_str_mv Article
http://purl.org/coar/resource_type/c_6501
VoR
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format article
dc.identifier.none.fl_str_mv https://ddd.uab.cat/record/256412
https://dx.doi.org/urn:doi:10.3389/fpsyt.2021.681876
url https://ddd.uab.cat/record/256412
https://dx.doi.org/urn:doi:10.3389/fpsyt.2021.681876
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.relation.none.fl_str_mv Instituto de Salud Carlos III https://doi.org/10.13039/501100004587 PI/15/02242
Instituto de Salud Carlos III https://doi.org/10.13039/501100004587 PI18/00009
Ministerio de Ciencia e Innovación https://doi.org/10.13039/501100004837 FI10/00017
Generalitat de Catalunya https://doi.org/10.13039/501100002809 PERIS; G60072253
Agència de Gestió d'Ajuts Universitaris i de Recerca https://doi.org/10.13039/501100003030 2017/SGR-134
Ministerio de Economía y Competitividad https://doi.org/10.13039/501100003329 PI15/00588
Instituto de Salud Carlos III https://doi.org/10.13039/501100004587 PI19/00009
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by/4.0/
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https://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Dipòsit Digital de Documents de la UAB
instname:Universitat Autònoma de Barcelona
instname_str Universitat Autònoma de Barcelona
reponame_str Dipòsit Digital de Documents de la UAB
collection Dipòsit Digital de Documents de la UAB
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repository.mail.fl_str_mv
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spelling Clinical Features, Neuropsychology and Neuroimaging in Bipolar and Borderline Personality DisorderA Systematic Review of Cross-Diagnostic StudiesMassó Rodriguez, AnnaHogg, Bridget|||0000-0002-2405-0593Gardoki-Souto, Itxaso|||0000-0002-0775-1275Valiente Gomez, Alicia|||0000-0003-0220-2397Trabsa, Amira|||0000-0002-8669-0676Mosquera, DoloresGarcía-Estela, Aitana|||0000-0001-8529-544XColom, Francesc|||0000-0002-9516-9030Pérez Solà, Víctor|||0000-0002-5825-2337Padberg, Frank|||0000-0001-7638-8310Moreno Alcázar, Ana|||0000-0002-3392-5590Amann, Benedikt L.|||0000-0002-4407-1519Bipolar disorderBorderline personality disorderClinical featuresCognitive functionsNeuroimagingAffective continuumBackground: Bipolar Disorder (BD) and Borderline Personality Disorder (BPD) have clinically been evolving as separate disorders, though there is still debate on the nosological valence of both conditions, their interaction in terms of co-morbidity or disorder spectrum and their distinct pathophysiology. Objective: The objective of this review is to summarize evidence regarding clinical features, neuropsychological performance and neuroimaging findings from cross-diagnostic studies comparing BD and BPD, to further caracterize their complex interplay. Methods: Using PubMed, PsycINFO and TripDataBase, we conducted a systematic literature search based on PRISMA guidelines of studies published from January 1980 to September 2019 which directly compared BD and BPD. Results: A total of 28 studies comparing BD and BPD were included: 19 compared clinical features, 6 neuropsychological performance and three neuroimaging abnormalities. Depressive symptoms have an earlier onset in BPD than BD. BD patients present more mixed or manic symptoms, with BD-I differing from BPD in manic phases. BPD patients show more negative attitudes toward others and self, more conflictive interpersonal relationships, and more maladaptive regulation strategies in affective instability with separate pathways. Impulsivity seems more a trait in BPD rather than a state as in BD. Otherwise, BD and BPD overlap in depressive and anxious symptoms, dysphoria, various abnormal temperamental traits, suicidal ideation, and childhood trauma. Both disorders differ and share deficits in neuropsychological and neuroimaging findings. Conclusion: Clinical data provide evidence of overlapping features in both disorders, with most of those shared symptoms being more persistent and intense in BPD. Thus, categorical classifications should be compared to dimensional approaches in transdiagnostic studies investigating BPD features in BD regarding their respective explanatory power for individual trajectories. Systematic Review Registration: The search strategy was pre-registered in PROSPERO: CRD42018100268. 22021-01-0120212021-01-01Articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://ddd.uab.cat/record/256412https://dx.doi.org/urn:doi:10.3389/fpsyt.2021.681876reponame:Dipòsit Digital de Documents de la UABinstname:Universitat Autònoma de BarcelonaInglésengInstituto de Salud Carlos III https://doi.org/10.13039/501100004587 PI/15/02242Instituto de Salud Carlos III https://doi.org/10.13039/501100004587 PI18/00009Ministerio de Ciencia e Innovación https://doi.org/10.13039/501100004837 FI10/00017Generalitat de Catalunya https://doi.org/10.13039/501100002809 PERIS; G60072253Agència de Gestió d'Ajuts Universitaris i de Recerca https://doi.org/10.13039/501100003030 2017/SGR-134Ministerio de Economía y Competitividad https://doi.org/10.13039/501100003329 PI15/00588Instituto de Salud Carlos III https://doi.org/10.13039/501100004587 PI19/00009open accesshttp://purl.org/coar/access_right/c_abf2Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:ddd.uab.cat:2564122026-06-06T12:50:31Z
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