Short- and Long-Term Neurobehavioral Effects of Developmental Exposure to Valproic Acid in Zebrafish

Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by impairments in social interaction and communication, anxiety, hyperactivity, and interest restricted to specific subjects. In addition to the genetic factors, multiple environmental factors have been related to the deve...

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Autores: Ricarte, Marina, Tagkalidou, Niki, Bellot, Marina, Bedrossiantz, Juliette, Prats, Eva, Gómez-Canela, Cristian, Garcia-Reyero, Natàlia, Raldúa, Demetrio
Tipo de recurso: artículo
Fecha de publicación:2024
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:20.500.14342/4750
Acceso en línea:http://hdl.handle.net/20.500.14342/4750
https://doi.org/10.3390/ijms25147688
Access Level:acceso abierto
Palabra clave:valproic acid
animal model
zebrafish
autism spectrum disorder
social behavior
neurotransmitter
615
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spelling Short- and Long-Term Neurobehavioral Effects of Developmental Exposure to Valproic Acid in ZebrafishRicarte, MarinaTagkalidou, NikiBellot, MarinaBedrossiantz, JuliettePrats, EvaGómez-Canela, CristianGarcia-Reyero, NatàliaRaldúa, Demetriovalproic acidanimal modelzebrafishautism spectrum disordersocial behaviorneurotransmitter615Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by impairments in social interaction and communication, anxiety, hyperactivity, and interest restricted to specific subjects. In addition to the genetic factors, multiple environmental factors have been related to the development of ASD. Animal models can serve as crucial tools for understanding the complexity of ASD. In this study, a chemical model of ASD has been developed in zebrafish by exposing embryos to valproic acid (VPA) from 4 to 48 h post-fertilization, rearing them to the adult stage in fish water. For the first time, an integrative approach combining behavioral analysis and neurotransmitters profile has been used for determining the effects of early-life exposure to VPA both in the larval and adult stages. Larvae from VPA-treated embryos showed hyperactivity and decreased visual and vibrational escape responses, as well as an altered neurotransmitters profile, with increased glutamate and decreased acetylcholine and norepinephrine levels. Adults from VPA-treated embryos exhibited impaired social behavior characterized by larger shoal sizes and a decreased interest for their conspecifics. A neurotransmitter analysis revealed a significant decrease in dopamine and GABA levels in the brain. These results support the potential predictive validity of this model for ASD research.info:eu-repo/semantics/publishedVersionMDPIUniversitat Ramon Llull. IQS2024info:eu-repo/semantics/article12 p.http://hdl.handle.net/20.500.14342/4750https://doi.org/10.3390/ijms25147688reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésInternational Journal of Molecular Sciences. 2024;25(14):7688info:eu-repo/grantAgreement/MCIN/PN I+D/PID2020-113371RB-C21info:eu-repo/grantAgreement/MCIN/PN I+D/PID2020-113371RB-C21info:eu-repo/grantAgreement/MCIN/PN I+D/TED2021-130845B-C3info:eu-repo/grantAgreement/MCIN i IDAEA-CSIC/PN I+D/CEX2018-000794-Sinfo:eu-repo/grantAgreement/MICIN i FSE/FI/PRE2018-083513© L'autor/aAttribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:recercat.cat:20.500.14342/47502026-05-29T05:05:01Z
dc.title.none.fl_str_mv Short- and Long-Term Neurobehavioral Effects of Developmental Exposure to Valproic Acid in Zebrafish
title Short- and Long-Term Neurobehavioral Effects of Developmental Exposure to Valproic Acid in Zebrafish
spellingShingle Short- and Long-Term Neurobehavioral Effects of Developmental Exposure to Valproic Acid in Zebrafish
Ricarte, Marina
valproic acid
animal model
zebrafish
autism spectrum disorder
social behavior
neurotransmitter
615
title_short Short- and Long-Term Neurobehavioral Effects of Developmental Exposure to Valproic Acid in Zebrafish
title_full Short- and Long-Term Neurobehavioral Effects of Developmental Exposure to Valproic Acid in Zebrafish
title_fullStr Short- and Long-Term Neurobehavioral Effects of Developmental Exposure to Valproic Acid in Zebrafish
title_full_unstemmed Short- and Long-Term Neurobehavioral Effects of Developmental Exposure to Valproic Acid in Zebrafish
title_sort Short- and Long-Term Neurobehavioral Effects of Developmental Exposure to Valproic Acid in Zebrafish
dc.creator.none.fl_str_mv Ricarte, Marina
Tagkalidou, Niki
Bellot, Marina
Bedrossiantz, Juliette
Prats, Eva
Gómez-Canela, Cristian
Garcia-Reyero, Natàlia
Raldúa, Demetrio
author Ricarte, Marina
author_facet Ricarte, Marina
Tagkalidou, Niki
Bellot, Marina
Bedrossiantz, Juliette
Prats, Eva
Gómez-Canela, Cristian
Garcia-Reyero, Natàlia
Raldúa, Demetrio
author_role author
author2 Tagkalidou, Niki
Bellot, Marina
Bedrossiantz, Juliette
Prats, Eva
Gómez-Canela, Cristian
Garcia-Reyero, Natàlia
Raldúa, Demetrio
author2_role author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universitat Ramon Llull. IQS
dc.subject.none.fl_str_mv valproic acid
animal model
zebrafish
autism spectrum disorder
social behavior
neurotransmitter
615
topic valproic acid
animal model
zebrafish
autism spectrum disorder
social behavior
neurotransmitter
615
description Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by impairments in social interaction and communication, anxiety, hyperactivity, and interest restricted to specific subjects. In addition to the genetic factors, multiple environmental factors have been related to the development of ASD. Animal models can serve as crucial tools for understanding the complexity of ASD. In this study, a chemical model of ASD has been developed in zebrafish by exposing embryos to valproic acid (VPA) from 4 to 48 h post-fertilization, rearing them to the adult stage in fish water. For the first time, an integrative approach combining behavioral analysis and neurotransmitters profile has been used for determining the effects of early-life exposure to VPA both in the larval and adult stages. Larvae from VPA-treated embryos showed hyperactivity and decreased visual and vibrational escape responses, as well as an altered neurotransmitters profile, with increased glutamate and decreased acetylcholine and norepinephrine levels. Adults from VPA-treated embryos exhibited impaired social behavior characterized by larger shoal sizes and a decreased interest for their conspecifics. A neurotransmitter analysis revealed a significant decrease in dopamine and GABA levels in the brain. These results support the potential predictive validity of this model for ASD research.
publishDate 2024
dc.date.none.fl_str_mv 2024
dc.type.none.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/20.500.14342/4750
https://doi.org/10.3390/ijms25147688
url http://hdl.handle.net/20.500.14342/4750
https://doi.org/10.3390/ijms25147688
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv International Journal of Molecular Sciences. 2024;25(14):7688
info:eu-repo/grantAgreement/MCIN/PN I+D/PID2020-113371RB-C21
info:eu-repo/grantAgreement/MCIN/PN I+D/PID2020-113371RB-C21
info:eu-repo/grantAgreement/MCIN/PN I+D/TED2021-130845B-C3
info:eu-repo/grantAgreement/MCIN i IDAEA-CSIC/PN I+D/CEX2018-000794-S
info:eu-repo/grantAgreement/MICIN i FSE/FI/PRE2018-083513
dc.rights.none.fl_str_mv © L'autor/a
Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv © L'autor/a
Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 12 p.
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.812429

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