Treating BCG-Induced Cystitis with Combined Chondroitin and Hyaluronic Acid Instillations in Bladder Cancer
In non-muscle invasive bladder cancer, Bacillus Calmette-Guérin (BCG) responders benefit from strong Th1-type inflammatory and T cell responses mediating tumor rejection. However, the corresponding lack of anti-inflammatory Th2-type immunity impairs tissue repair in the bladder wall and facilitates...
| Autores: | , , , , , , , , , , , , , , , , , |
|---|---|
| Formato: | artículo |
| Fecha de publicación: | 2024 |
| País: | España |
| Recursos: | Universitat Autònoma de Barcelona |
| Repositorio: | Dipòsit Digital de Documents de la UAB |
| Idioma: | inglés |
| OAI Identifier: | oai:ddd.uab.cat:306323 |
| Acesso em linha: | https://ddd.uab.cat/record/306323 https://dx.doi.org/urn:doi:10.3390/jcm13072031 |
| Access Level: | acceso abierto |
| Palavra-chave: | BCG Bladder cancer Chondroitin Cystitis Hyaluronic acid Intravesical instillations |
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Treating BCG-Induced Cystitis with Combined Chondroitin and Hyaluronic Acid Instillations in Bladder CancerPichler, Renate|||0000-0001-5286-9048Stäblein, JohannesMari, Andrea|||0000-0001-9070-5706Afferi, Luca|||0000-0002-5472-1933D'Andrea, David|||0000-0003-1625-1077Marcq, Gautier|||0000-0002-1806-1448Del Giudice, Francesco|||0000-0003-3865-5988Soria, Francesco|||0000-0001-8443-8453Caño-Velasco, JorgeSubiela, José Daniel|||0000-0003-4176-8174Gallioli, Andrea|||0000-0002-3316-5691Tully, Karl Heinrich|||0000-0002-9499-0169Mori, Keiichiro|||0000-0002-6147-6569Herms, AchimPradere, Benjamin|||0000-0002-7768-8558Moschini, Marco|||0000-0002-3084-2458Mertens, Laura S.|||0000-0003-3317-6427Thurnher, Martin|||0000-0001-9940-7326BCGBladder cancerChondroitinCystitisHyaluronic acidIntravesical instillationsIn non-muscle invasive bladder cancer, Bacillus Calmette-Guérin (BCG) responders benefit from strong Th1-type inflammatory and T cell responses mediating tumor rejection. However, the corresponding lack of anti-inflammatory Th2-type immunity impairs tissue repair in the bladder wall and facilitates the development of cystitis, causing urinary pain, urgency, incontinence, and frequency. Mechanistically, the leakage of the glycosaminoglycan (GAG) layer enables an influx of potassium ions, bacteria, and urine solutes towards the underlying bladder tissue, promoting chronic inflammation. Treatments directed towards re-establishing this mucopolysaccharide-based protective barrier are urgently needed. We discuss the pathomechanisms, as well as the therapeutic rationale of how chondroitin and hyaluronic acid instillations can reduce or prevent BCG-induced irritative bladder symptoms. Moreover, we present a case series of five patients with refractory BCG-induced cystitis successfully treated with combined chondroitin and hyaluronic acid instillations.Universitat Autònoma de Barcelona 22024-01-0120242024-01-01Articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://ddd.uab.cat/record/306323https://dx.doi.org/urn:doi:10.3390/jcm13072031reponame:Dipòsit Digital de Documents de la UABinstname:Universitat Autònoma de BarcelonaInglésengopen accesshttp://purl.org/coar/access_right/c_abf2Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:ddd.uab.cat:3063232026-06-06T12:50:31Z |
| dc.title.none.fl_str_mv |
Treating BCG-Induced Cystitis with Combined Chondroitin and Hyaluronic Acid Instillations in Bladder Cancer |
| title |
Treating BCG-Induced Cystitis with Combined Chondroitin and Hyaluronic Acid Instillations in Bladder Cancer |
| spellingShingle |
Treating BCG-Induced Cystitis with Combined Chondroitin and Hyaluronic Acid Instillations in Bladder Cancer Pichler, Renate|||0000-0001-5286-9048 BCG Bladder cancer Chondroitin Cystitis Hyaluronic acid Intravesical instillations |
| title_short |
Treating BCG-Induced Cystitis with Combined Chondroitin and Hyaluronic Acid Instillations in Bladder Cancer |
| title_full |
Treating BCG-Induced Cystitis with Combined Chondroitin and Hyaluronic Acid Instillations in Bladder Cancer |
| title_fullStr |
Treating BCG-Induced Cystitis with Combined Chondroitin and Hyaluronic Acid Instillations in Bladder Cancer |
| title_full_unstemmed |
Treating BCG-Induced Cystitis with Combined Chondroitin and Hyaluronic Acid Instillations in Bladder Cancer |
| title_sort |
Treating BCG-Induced Cystitis with Combined Chondroitin and Hyaluronic Acid Instillations in Bladder Cancer |
| dc.creator.none.fl_str_mv |
Pichler, Renate|||0000-0001-5286-9048 Stäblein, Johannes Mari, Andrea|||0000-0001-9070-5706 Afferi, Luca|||0000-0002-5472-1933 D'Andrea, David|||0000-0003-1625-1077 Marcq, Gautier|||0000-0002-1806-1448 Del Giudice, Francesco|||0000-0003-3865-5988 Soria, Francesco|||0000-0001-8443-8453 Caño-Velasco, Jorge Subiela, José Daniel|||0000-0003-4176-8174 Gallioli, Andrea|||0000-0002-3316-5691 Tully, Karl Heinrich|||0000-0002-9499-0169 Mori, Keiichiro|||0000-0002-6147-6569 Herms, Achim Pradere, Benjamin|||0000-0002-7768-8558 Moschini, Marco|||0000-0002-3084-2458 Mertens, Laura S.|||0000-0003-3317-6427 Thurnher, Martin|||0000-0001-9940-7326 |
| author |
Pichler, Renate|||0000-0001-5286-9048 |
| author_facet |
Pichler, Renate|||0000-0001-5286-9048 Stäblein, Johannes Mari, Andrea|||0000-0001-9070-5706 Afferi, Luca|||0000-0002-5472-1933 D'Andrea, David|||0000-0003-1625-1077 Marcq, Gautier|||0000-0002-1806-1448 Del Giudice, Francesco|||0000-0003-3865-5988 Soria, Francesco|||0000-0001-8443-8453 Caño-Velasco, Jorge Subiela, José Daniel|||0000-0003-4176-8174 Gallioli, Andrea|||0000-0002-3316-5691 Tully, Karl Heinrich|||0000-0002-9499-0169 Mori, Keiichiro|||0000-0002-6147-6569 Herms, Achim Pradere, Benjamin|||0000-0002-7768-8558 Moschini, Marco|||0000-0002-3084-2458 Mertens, Laura S.|||0000-0003-3317-6427 Thurnher, Martin|||0000-0001-9940-7326 |
| author_role |
author |
| author2 |
Stäblein, Johannes Mari, Andrea|||0000-0001-9070-5706 Afferi, Luca|||0000-0002-5472-1933 D'Andrea, David|||0000-0003-1625-1077 Marcq, Gautier|||0000-0002-1806-1448 Del Giudice, Francesco|||0000-0003-3865-5988 Soria, Francesco|||0000-0001-8443-8453 Caño-Velasco, Jorge Subiela, José Daniel|||0000-0003-4176-8174 Gallioli, Andrea|||0000-0002-3316-5691 Tully, Karl Heinrich|||0000-0002-9499-0169 Mori, Keiichiro|||0000-0002-6147-6569 Herms, Achim Pradere, Benjamin|||0000-0002-7768-8558 Moschini, Marco|||0000-0002-3084-2458 Mertens, Laura S.|||0000-0003-3317-6427 Thurnher, Martin|||0000-0001-9940-7326 |
| author2_role |
author author author author author author author author author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
Universitat Autònoma de Barcelona |
| dc.subject.none.fl_str_mv |
BCG Bladder cancer Chondroitin Cystitis Hyaluronic acid Intravesical instillations |
| topic |
BCG Bladder cancer Chondroitin Cystitis Hyaluronic acid Intravesical instillations |
| description |
In non-muscle invasive bladder cancer, Bacillus Calmette-Guérin (BCG) responders benefit from strong Th1-type inflammatory and T cell responses mediating tumor rejection. However, the corresponding lack of anti-inflammatory Th2-type immunity impairs tissue repair in the bladder wall and facilitates the development of cystitis, causing urinary pain, urgency, incontinence, and frequency. Mechanistically, the leakage of the glycosaminoglycan (GAG) layer enables an influx of potassium ions, bacteria, and urine solutes towards the underlying bladder tissue, promoting chronic inflammation. Treatments directed towards re-establishing this mucopolysaccharide-based protective barrier are urgently needed. We discuss the pathomechanisms, as well as the therapeutic rationale of how chondroitin and hyaluronic acid instillations can reduce or prevent BCG-induced irritative bladder symptoms. Moreover, we present a case series of five patients with refractory BCG-induced cystitis successfully treated with combined chondroitin and hyaluronic acid instillations. |
| publishDate |
2024 |
| dc.date.none.fl_str_mv |
2 2024-01-01 2024 2024-01-01 |
| dc.type.none.fl_str_mv |
Article http://purl.org/coar/resource_type/c_6501 VoR http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| dc.type.openaire.fl_str_mv |
info:eu-repo/semantics/article |
| format |
article |
| dc.identifier.none.fl_str_mv |
https://ddd.uab.cat/record/306323 https://dx.doi.org/urn:doi:10.3390/jcm13072031 |
| url |
https://ddd.uab.cat/record/306323 https://dx.doi.org/urn:doi:10.3390/jcm13072031 |
| dc.language.none.fl_str_mv |
Inglés eng |
| language_invalid_str_mv |
Inglés |
| language |
eng |
| dc.rights.none.fl_str_mv |
open access http://purl.org/coar/access_right/c_abf2 https://creativecommons.org/licenses/by/4.0/ |
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info:eu-repo/semantics/openAccess |
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open access http://purl.org/coar/access_right/c_abf2 https://creativecommons.org/licenses/by/4.0/ |
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openAccess |
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application/pdf |
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reponame:Dipòsit Digital de Documents de la UAB instname:Universitat Autònoma de Barcelona |
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