Biomedical Applications of the Biopolymer Poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV): Drug Encapsulation and Scaffold Fabrication

Poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) is a biodegradable and biocompatible biopolymer that has gained popularity in the field of biomedicine. This review provides an overview of recent advances and potential applications of PHBV, with special emphasis on drug encapsulation and scaffold...

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Autores: Rodríguez Cendal, Ana Isabel, Gómez Seoane, Iván, De Toro Santos, Francisco Javier, Fuentes Boquete, Isaac, Señaris Rodriguez, Jose, Díaz Prado, Silvia María
Tipo de recurso: artículo
Fecha de publicación:2023
País:España
Institución:Servizo Galego de Saúde (SERGAS)
Repositorio:RUNA. Repositorio da Consellería de Sanidade e Sergas
OAI Identifier:oai:runa.sergas.gal:20.500.11940/21159
Acceso en línea:https://portalcientifico.sergas.gal//documentos/64e2a52e4a4f093d56e71ce5
http://hdl.handle.net/20.500.11940/21159
Access Level:acceso abierto
Palabra clave:Tissue Scaffolds
Pharmaceutical Preparations
Polyesters
Tissue Engineering
CHUAC
INIBIC
AS A Coruña
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spelling Biomedical Applications of the Biopolymer Poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV): Drug Encapsulation and Scaffold FabricationRodríguez Cendal, Ana IsabelGómez Seoane, IvánDe Toro Santos, Francisco JavierFuentes Boquete, IsaacSeñaris Rodriguez, JoseDíaz Prado, Silvia MaríaTissue ScaffoldsPharmaceutical PreparationsPolyestersTissue EngineeringCHUACINIBICAS A CoruñaINIBICAS A CoruñaCHUACAS A CoruñaCHUACAS A CoruñaCHUACPoly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) is a biodegradable and biocompatible biopolymer that has gained popularity in the field of biomedicine. This review provides an overview of recent advances and potential applications of PHBV, with special emphasis on drug encapsulation and scaffold construction. PHBV has shown to be a versatile platform for drug delivery, offering controlled release, enhanced therapeutic efficacy, and reduced side effects. The encapsulation of various drugs, such as anticancer agents, antibiotics, and anti-inflammatory drugs, in PHBV nanoparticles or microspheres has been extensively investigated, demonstrating enhanced drug stability, prolonged release kinetics, and increased bioavailability. Additionally, PHBV has been used as a scaffold material for tissue engineering applications, such as bone, cartilage, and skin regeneration. The incorporation of PHBV into scaffolds has been shown to improve mechanical properties, biocompatibility, and cellular interactions, making them suitable for tissue engineering constructs. This review highlights the potential of PHBV in drug encapsulation and scaffold fabrication, showing its promising role in advancing biomedical applications.Instituto de Salud Carlos III-General Subdirection of Assessment and Promotion of the Research-European Regional Development Fund (FEDER) A way of making Europe (PI20/00933 and PI17/02197), ayudas para proyectos Semilla-Disruptivos entre grupos del CICA 2O21 (POLIBIOMED) de la Universidade de A Coruna, Grupos con Potencial de Crecemento, Xunta de Galicia (ED431B 2020/55) and Fundacion Profesor Novoa Santos, proyectos de Desarrollo y Transferencia 2022.2023info:eu-repo/semantics/articlehttps://portalcientifico.sergas.gal//documentos/64e2a52e4a4f093d56e71ce5http://hdl.handle.net/20.500.11940/21159reponame:RUNA. Repositorio da Consellería de Sanidade e Sergasinstname:Servizo Galego de Saúde (SERGAS)Ingléshttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:runa.sergas.gal:20.500.11940/211592026-06-12T08:40:47Z
dc.title.none.fl_str_mv Biomedical Applications of the Biopolymer Poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV): Drug Encapsulation and Scaffold Fabrication
title Biomedical Applications of the Biopolymer Poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV): Drug Encapsulation and Scaffold Fabrication
spellingShingle Biomedical Applications of the Biopolymer Poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV): Drug Encapsulation and Scaffold Fabrication
Rodríguez Cendal, Ana Isabel
Tissue Scaffolds
Pharmaceutical Preparations
Polyesters
Tissue Engineering
CHUAC
INIBIC
AS A Coruña
INIBIC
AS A Coruña
CHUAC
AS A Coruña
CHUAC
AS A Coruña
CHUAC
title_short Biomedical Applications of the Biopolymer Poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV): Drug Encapsulation and Scaffold Fabrication
title_full Biomedical Applications of the Biopolymer Poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV): Drug Encapsulation and Scaffold Fabrication
title_fullStr Biomedical Applications of the Biopolymer Poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV): Drug Encapsulation and Scaffold Fabrication
title_full_unstemmed Biomedical Applications of the Biopolymer Poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV): Drug Encapsulation and Scaffold Fabrication
title_sort Biomedical Applications of the Biopolymer Poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV): Drug Encapsulation and Scaffold Fabrication
dc.creator.none.fl_str_mv Rodríguez Cendal, Ana Isabel
Gómez Seoane, Iván
De Toro Santos, Francisco Javier
Fuentes Boquete, Isaac
Señaris Rodriguez, Jose
Díaz Prado, Silvia María
author Rodríguez Cendal, Ana Isabel
author_facet Rodríguez Cendal, Ana Isabel
Gómez Seoane, Iván
De Toro Santos, Francisco Javier
Fuentes Boquete, Isaac
Señaris Rodriguez, Jose
Díaz Prado, Silvia María
author_role author
author2 Gómez Seoane, Iván
De Toro Santos, Francisco Javier
Fuentes Boquete, Isaac
Señaris Rodriguez, Jose
Díaz Prado, Silvia María
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv Tissue Scaffolds
Pharmaceutical Preparations
Polyesters
Tissue Engineering
CHUAC
INIBIC
AS A Coruña
INIBIC
AS A Coruña
CHUAC
AS A Coruña
CHUAC
AS A Coruña
CHUAC
topic Tissue Scaffolds
Pharmaceutical Preparations
Polyesters
Tissue Engineering
CHUAC
INIBIC
AS A Coruña
INIBIC
AS A Coruña
CHUAC
AS A Coruña
CHUAC
AS A Coruña
CHUAC
description Poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) is a biodegradable and biocompatible biopolymer that has gained popularity in the field of biomedicine. This review provides an overview of recent advances and potential applications of PHBV, with special emphasis on drug encapsulation and scaffold construction. PHBV has shown to be a versatile platform for drug delivery, offering controlled release, enhanced therapeutic efficacy, and reduced side effects. The encapsulation of various drugs, such as anticancer agents, antibiotics, and anti-inflammatory drugs, in PHBV nanoparticles or microspheres has been extensively investigated, demonstrating enhanced drug stability, prolonged release kinetics, and increased bioavailability. Additionally, PHBV has been used as a scaffold material for tissue engineering applications, such as bone, cartilage, and skin regeneration. The incorporation of PHBV into scaffolds has been shown to improve mechanical properties, biocompatibility, and cellular interactions, making them suitable for tissue engineering constructs. This review highlights the potential of PHBV in drug encapsulation and scaffold fabrication, showing its promising role in advancing biomedical applications.
publishDate 2023
dc.date.none.fl_str_mv 2023
dc.type.none.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://portalcientifico.sergas.gal//documentos/64e2a52e4a4f093d56e71ce5
http://hdl.handle.net/20.500.11940/21159
url https://portalcientifico.sergas.gal//documentos/64e2a52e4a4f093d56e71ce5
http://hdl.handle.net/20.500.11940/21159
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv http://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.source.none.fl_str_mv reponame:RUNA. Repositorio da Consellería de Sanidade e Sergas
instname:Servizo Galego de Saúde (SERGAS)
instname_str Servizo Galego de Saúde (SERGAS)
reponame_str RUNA. Repositorio da Consellería de Sanidade e Sergas
collection RUNA. Repositorio da Consellería de Sanidade e Sergas
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,811543

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