Phosphorylated tau181 in plasma as a potential biomarker for Alzheimer's disease in adults with Down syndrome

Plasma tau phosphorylated at threonine 181 (p-tau181) predicts Alzheimer's disease (AD) pathology with high accuracy in the general population. In this study, we investigated plasma p-tau181 as a biomarker of AD in individuals with Down syndrome (DS). We included 366 adults with DS (240 asympto...

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Authors: Lleo, A, Zetterberg, H, Pegueroles, J, Karikari, TK, Carmona-Iragui, M, Ashton, NJ, Montal, V, Barroeta, I, Lantero-Rodriguez, J, Videla, L, Altuna, M, Benejam, B, Fernandez, S, Valldeneu, S, Garzon, D, Bejanin, A, Iulita, MF, Camacho, V, Medrano-Martorell, S, Belbin, O, Clarimon, J, Lehmann, S, Alcolea, D, Blesa, R, Blennow, K, Fortea, J
Format: article
Status:Published version
Publication Date:2021
Country:España
Institution:Institut d’Investigació Biomèdica Sant Pau (IIB Sant Pau)
Repository:r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
OAI Identifier:oai:iibsantpau.fundanetsuite.com:p4518
Online Access:https://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=4518
Access Level:Open access
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spelling Phosphorylated tau181 in plasma as a potential biomarker for Alzheimer's disease in adults with Down syndromeLleo, AZetterberg, HPegueroles, JKarikari, TKCarmona-Iragui, MAshton, NJMontal, VBarroeta, ILantero-Rodriguez, JVidela, LAltuna, MBenejam, BFernandez, SValldeneu, SGarzon, DBejanin, AIulita, MFCamacho, VMedrano-Martorell, SBelbin, OClarimon, JLehmann, SAlcolea, DBlesa, RBlennow, KFortea, JPlasma tau phosphorylated at threonine 181 (p-tau181) predicts Alzheimer's disease (AD) pathology with high accuracy in the general population. In this study, we investigated plasma p-tau181 as a biomarker of AD in individuals with Down syndrome (DS). We included 366 adults with DS (240 asymptomatic, 43 prodromal AD, 83 AD dementia) and 44 euploid cognitively normal controls. We measured plasma p-tau181 with a Single molecule array (Simoa) assay. We examined the diagnostic performance of p-tau181 for the detection of AD and the relationship with other fluid and imaging biomarkers. Plasma p-tau181 concentration showed an area under the curve of 0.80 [95% CI 0.73-0.87] and 0.92 [95% CI 0.89-0.95] for the discrimination between asymptomatic individuals versus those in the prodromal and dementia groups, respectively. Plasma p-tau181 correlated with atrophy and hypometabolism in temporoparietal regions. Our findings indicate that plasma p-tau181 concentration can be useful to detect AD in DS. Plasma tau phosphorylated at threonine 181 (p-tau181) predicts Alzheimer's disease (AD) pathology. Here, the authors investigated whether plasma ptau181 could be a potential biomarker of AD in individuals with Down syndrome (DS) and find plasma p-tau181 can detect AD in DS adults.NATURE PUBLISHING GROUP2021info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=4518Nature CommunicationsISSN: 20411723reponame:r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pauinstname:Institut d’Investigació Biomèdica Sant Pau (IIB Sant Pau)Inglésinfo:eu-repo/semantics/openAccessoai:iibsantpau.fundanetsuite.com:p45182026-06-14T12:41:47Z
dc.title.none.fl_str_mv Phosphorylated tau181 in plasma as a potential biomarker for Alzheimer's disease in adults with Down syndrome
title Phosphorylated tau181 in plasma as a potential biomarker for Alzheimer's disease in adults with Down syndrome
spellingShingle Phosphorylated tau181 in plasma as a potential biomarker for Alzheimer's disease in adults with Down syndrome
Lleo, A
title_short Phosphorylated tau181 in plasma as a potential biomarker for Alzheimer's disease in adults with Down syndrome
title_full Phosphorylated tau181 in plasma as a potential biomarker for Alzheimer's disease in adults with Down syndrome
title_fullStr Phosphorylated tau181 in plasma as a potential biomarker for Alzheimer's disease in adults with Down syndrome
title_full_unstemmed Phosphorylated tau181 in plasma as a potential biomarker for Alzheimer's disease in adults with Down syndrome
title_sort Phosphorylated tau181 in plasma as a potential biomarker for Alzheimer's disease in adults with Down syndrome
dc.creator.none.fl_str_mv Lleo, A
Zetterberg, H
Pegueroles, J
Karikari, TK
Carmona-Iragui, M
Ashton, NJ
Montal, V
Barroeta, I
Lantero-Rodriguez, J
Videla, L
Altuna, M
Benejam, B
Fernandez, S
Valldeneu, S
Garzon, D
Bejanin, A
Iulita, MF
Camacho, V
Medrano-Martorell, S
Belbin, O
Clarimon, J
Lehmann, S
Alcolea, D
Blesa, R
Blennow, K
Fortea, J
author Lleo, A
author_facet Lleo, A
Zetterberg, H
Pegueroles, J
Karikari, TK
Carmona-Iragui, M
Ashton, NJ
Montal, V
Barroeta, I
Lantero-Rodriguez, J
Videla, L
Altuna, M
Benejam, B
Fernandez, S
Valldeneu, S
Garzon, D
Bejanin, A
Iulita, MF
Camacho, V
Medrano-Martorell, S
Belbin, O
Clarimon, J
Lehmann, S
Alcolea, D
Blesa, R
Blennow, K
Fortea, J
author_role author
author2 Zetterberg, H
Pegueroles, J
Karikari, TK
Carmona-Iragui, M
Ashton, NJ
Montal, V
Barroeta, I
Lantero-Rodriguez, J
Videla, L
Altuna, M
Benejam, B
Fernandez, S
Valldeneu, S
Garzon, D
Bejanin, A
Iulita, MF
Camacho, V
Medrano-Martorell, S
Belbin, O
Clarimon, J
Lehmann, S
Alcolea, D
Blesa, R
Blennow, K
Fortea, J
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
description Plasma tau phosphorylated at threonine 181 (p-tau181) predicts Alzheimer's disease (AD) pathology with high accuracy in the general population. In this study, we investigated plasma p-tau181 as a biomarker of AD in individuals with Down syndrome (DS). We included 366 adults with DS (240 asymptomatic, 43 prodromal AD, 83 AD dementia) and 44 euploid cognitively normal controls. We measured plasma p-tau181 with a Single molecule array (Simoa) assay. We examined the diagnostic performance of p-tau181 for the detection of AD and the relationship with other fluid and imaging biomarkers. Plasma p-tau181 concentration showed an area under the curve of 0.80 [95% CI 0.73-0.87] and 0.92 [95% CI 0.89-0.95] for the discrimination between asymptomatic individuals versus those in the prodromal and dementia groups, respectively. Plasma p-tau181 correlated with atrophy and hypometabolism in temporoparietal regions. Our findings indicate that plasma p-tau181 concentration can be useful to detect AD in DS. Plasma tau phosphorylated at threonine 181 (p-tau181) predicts Alzheimer's disease (AD) pathology. Here, the authors investigated whether plasma ptau181 could be a potential biomarker of AD in individuals with Down syndrome (DS) and find plasma p-tau181 can detect AD in DS adults.
publishDate 2021
dc.date.none.fl_str_mv 2021
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=4518
url https://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=4518
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv NATURE PUBLISHING GROUP
publisher.none.fl_str_mv NATURE PUBLISHING GROUP
dc.source.none.fl_str_mv Nature Communications
ISSN: 20411723
reponame:r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
instname:Institut d’Investigació Biomèdica Sant Pau (IIB Sant Pau)
instname_str Institut d’Investigació Biomèdica Sant Pau (IIB Sant Pau)
reponame_str r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
collection r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
repository.name.fl_str_mv
repository.mail.fl_str_mv
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