Stimuli-responsive mesoporous nanomatrices for drug delivery
The overall objective of this PhD thesis has been the design and production of engineered mesoporous nanoparticles for biomedical applications. In this sense, the efforts during this doctoral thesis have been headed towards the development of nanomatrices with potential applicability in the treatmen...
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| Tipo de recurso: | tesis doctoral |
| Fecha de publicación: | 2019 |
| País: | España |
| Institución: | Universidad Complutense de Madrid (UCM) |
| Repositorio: | Docta Complutense |
| Idioma: | inglés |
| OAI Identifier: | oai:docta.ucm.es:20.500.14352/10772 |
| Acceso en línea: | https://hdl.handle.net/20.500.14352/10772 |
| Access Level: | acceso abierto |
| Palabra clave: | 539.2:620.1(043.2) Nanopartículas Nanoparticules Farmacia |
| Sumario: | The overall objective of this PhD thesis has been the design and production of engineered mesoporous nanoparticles for biomedical applications. In this sense, the efforts during this doctoral thesis have been headed towards the development of nanomatrices with potential applicability in the treatment of complex diseases, such as bone and wound healing and cancer. The initial context of this doctoral thesis was the European project “MOZART” (“MesopOrous matrices for localiZed pH-triggered releAse of theRapeuTic ions and drugs”), which included many different European partners (11) from both academic and industrial environments. The proposal involved the use of mesoporous materials to treat delayed bone healing and chronic wound healing. The objective was to load therapeutic agents and ions within the mesoporous framework that would be released in the affected areas, boosting the healing and improving the health of the patients. The use of a stimuli responsive gatekeeper for the pore entrances to minimize potential premature release was considered. In this sense, the acid pH that was expected to be found in those pathological scenarios was selected as stimulus to trigger the payload release... |
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