Polypropylene and polyvinylidene fluoride transobturator slings for the treatment of female stress urinary incontinence

To compare the effectiveness and safety of polypropylene (PP) and polyvinylidene fluoride (PVDF) transobturator tapes (TOT) for the treatment of female stress urinary incontinence (SUI). This is a multicentre randomized trial. Women with SUI or stress-predominant mixed urinary incontinence and sched...

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Detalles Bibliográficos
Autores: Sabadell, Jordi|||0000-0001-9380-0338, Pereda-Núñez, Anna, Ojeda-de-los-Santos, Fernando, Urbaneja, Manuel, González-García, Carmen, Camps-Lloveras, Narcís, Pérez-Plantado, Àngela, Canet Rodriguez, Judit|||0000-0001-7387-1462, Pérez-Espejo, Maria Paz, Rodríguez-Mias, Nuria, Sarasa-Castelló, Núria, Palau Gauthier, Marta|||0000-0002-4567-9868, Montero-Armengol, Anabel, Salicrú, Sabina, Gil-Moreno, Antonio|||0000-0003-1106-5590, Poza, Jose L.
Tipo de recurso: artículo
Fecha de publicación:2020
País:España
Institución:Universitat Autònoma de Barcelona
Repositorio:Dipòsit Digital de Documents de la UAB
Idioma:inglés
OAI Identifier:oai:ddd.uab.cat:238671
Acceso en línea:https://ddd.uab.cat/record/238671
https://dx.doi.org/urn:doi:10.1002/nau.24586
Access Level:acceso abierto
Palabra clave:De novo urgency incontinence
Midurethral sling
Polypropylene
Polyvinylidene fluoride
PVDF
Sling complications
Stress urinary incontinence
Suburethral sling
Suburethral tape
Transobturator
Descripción
Sumario:To compare the effectiveness and safety of polypropylene (PP) and polyvinylidene fluoride (PVDF) transobturator tapes (TOT) for the treatment of female stress urinary incontinence (SUI). This is a multicentre randomized trial. Women with SUI or stress-predominant mixed urinary incontinence and scheduled for a TOT procedure were randomized to PP or PVDF slings. The primary outcome was 1-year cure or improvement rate using composite criteria. Complications were also compared. Relationships with outcomes were analyzed using multivariable logistic regressions models. From April 2016 to January 2018 285 participants were randomized. PP and PVDF slings showed similar high cure or improvement rate (91.0% vs. 95.6%, p = .138). Improvement in validated questionnaires was also similar. PVDF slings were associated with a lower rate of de novo urgency incontinence (adjusted odds ratio = 0.35; 95% confidence interval = 0.15-0.80). We found no statistical differences in complications rates, although a higher incidence of long-term pain events were observed in the PP group. The study is underpowered to find differences in specific complications owing to the low number of events. PP and PVDF TOTs are equally effective, although PVDF is associated with fewer cases of de novo urgency incontinence. Further studies are needed to give robust conclusions on safety profiles.

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