PVT1 long non-coding RNA in gastrointestinal cancer

Whole genome and transcriptome sequencing technologies have led to the identification of many long non-coding RNAs (lncRNAs) and stimulated the research of their role in health and disease. LncRNAs participate in the regulation of critical signaling pathways including cell growth, motility, apoptosi...

Descripción completa

Detalles Bibliográficos
Autores: Martínez Barriocanal, Águeda, Arango, Diego, Dopeso, Higinio
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2020
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:10459.1/70057
Acceso en línea:https://doi.org/10.3389/fonc.2020.00038
http://hdl.handle.net/10459.1/70057
Access Level:acceso abierto
Palabra clave:ceRNA
PVT1
lncRNA
siRNA
Còlon--Càncer
id ES_2222de4e8bbb27ddbdc2a64fe1975372
oai_identifier_str oai:recercat.cat:10459.1/70057
network_acronym_str ES
network_name_str España
repository_id_str
spelling PVT1 long non-coding RNA in gastrointestinal cancerMartínez Barriocanal, ÁguedaArango, DiegoDopeso, HiginioceRNAPVT1lncRNAsiRNACòlon--CàncerWhole genome and transcriptome sequencing technologies have led to the identification of many long non-coding RNAs (lncRNAs) and stimulated the research of their role in health and disease. LncRNAs participate in the regulation of critical signaling pathways including cell growth, motility, apoptosis, and differentiation; and their expression has been found dysregulated in human tumors. Thus, lncRNAs have emerged as new players in the initiation, maintenance and progression of tumorigenesis. PVT1 (plasmacytoma variant translocation 1) lncRNA is located on chromosomal 8q24.21, a large locus frequently amplified in human cancers and predictive of increased cancer risk in genome-wide association studies (GWAS). Combined, colorectal and gastric adenocarcinomas are the most frequent tumor malignancies and also the leading cause of cancer-related deaths worldwide. PVT1 expression is elevated in gastrointestinal tumors and correlates with poor patient prognosis. In this review, we discuss the mechanisms of action underlying PVT1 oncogenic role in colorectal and gastric cancer such as MYC upregulation, miRNA production, competitive endogenous RNA (ceRNA) function, protein stabilization, and epigenetic regulation. We also illustrate the potential role of PVT1 as prognostic biomarker and its relationship with resistance to current chemotherapeutic treatments.This study was partially funded by grants of the Spanish Ministry for Economy and Competitiveness (PI16/00540, AC15/00066, AC19/00095, and PI19/00993) and the Spanish Association Against Cancer (AECC GCA15152966ARAN) to DA.Frontiers Media202020202020info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://doi.org/10.3389/fonc.2020.00038http://hdl.handle.net/10459.1/70057http://hdl.handle.net/10459.1/70057reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésReproducció del document publicat a https://doi.org/10.3389/fonc.2020.00038Frontiers in Oncology, 2020, vol. 10, núm. 38, p.1-16cc-by (c) Martínez et al., 2020info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by/4.0/oai:recercat.cat:10459.1/700572026-05-29T05:05:01Z
dc.title.none.fl_str_mv PVT1 long non-coding RNA in gastrointestinal cancer
title PVT1 long non-coding RNA in gastrointestinal cancer
spellingShingle PVT1 long non-coding RNA in gastrointestinal cancer
Martínez Barriocanal, Águeda
ceRNA
PVT1
lncRNA
siRNA
Còlon--Càncer
title_short PVT1 long non-coding RNA in gastrointestinal cancer
title_full PVT1 long non-coding RNA in gastrointestinal cancer
title_fullStr PVT1 long non-coding RNA in gastrointestinal cancer
title_full_unstemmed PVT1 long non-coding RNA in gastrointestinal cancer
title_sort PVT1 long non-coding RNA in gastrointestinal cancer
dc.creator.none.fl_str_mv Martínez Barriocanal, Águeda
Arango, Diego
Dopeso, Higinio
author Martínez Barriocanal, Águeda
author_facet Martínez Barriocanal, Águeda
Arango, Diego
Dopeso, Higinio
author_role author
author2 Arango, Diego
Dopeso, Higinio
author2_role author
author
dc.subject.none.fl_str_mv ceRNA
PVT1
lncRNA
siRNA
Còlon--Càncer
topic ceRNA
PVT1
lncRNA
siRNA
Còlon--Càncer
description Whole genome and transcriptome sequencing technologies have led to the identification of many long non-coding RNAs (lncRNAs) and stimulated the research of their role in health and disease. LncRNAs participate in the regulation of critical signaling pathways including cell growth, motility, apoptosis, and differentiation; and their expression has been found dysregulated in human tumors. Thus, lncRNAs have emerged as new players in the initiation, maintenance and progression of tumorigenesis. PVT1 (plasmacytoma variant translocation 1) lncRNA is located on chromosomal 8q24.21, a large locus frequently amplified in human cancers and predictive of increased cancer risk in genome-wide association studies (GWAS). Combined, colorectal and gastric adenocarcinomas are the most frequent tumor malignancies and also the leading cause of cancer-related deaths worldwide. PVT1 expression is elevated in gastrointestinal tumors and correlates with poor patient prognosis. In this review, we discuss the mechanisms of action underlying PVT1 oncogenic role in colorectal and gastric cancer such as MYC upregulation, miRNA production, competitive endogenous RNA (ceRNA) function, protein stabilization, and epigenetic regulation. We also illustrate the potential role of PVT1 as prognostic biomarker and its relationship with resistance to current chemotherapeutic treatments.
publishDate 2020
dc.date.none.fl_str_mv 2020
2020
2020
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://doi.org/10.3389/fonc.2020.00038
http://hdl.handle.net/10459.1/70057
http://hdl.handle.net/10459.1/70057
url https://doi.org/10.3389/fonc.2020.00038
http://hdl.handle.net/10459.1/70057
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a https://doi.org/10.3389/fonc.2020.00038
Frontiers in Oncology, 2020, vol. 10, núm. 38, p.1-16
dc.rights.none.fl_str_mv cc-by (c) Martínez et al., 2020
info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by/4.0/
rights_invalid_str_mv cc-by (c) Martínez et al., 2020
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Frontiers Media
publisher.none.fl_str_mv Frontiers Media
dc.source.none.fl_str_mv reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869404559803154432
score 15,812455

Similares en LA Referencia