Osteoblastic cell response to spark plasma-sintered zirconia/titanium cermets

Ceramic/metal composites, cermets, arise from the idea to combine the dissimilar properties in the pure materials. This work aims to study the biocompatibility of new micro-nanostructured 3Y-TZP/Ti materials with 25, 50 and 75vol.% Ti, which have been successfully obtained by spark slasma sintering...

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Autores: Fernandez Garcia, Elisa, Guillem Martí, Jordi|||0000-0003-0307-2221, Gutierrez Gonzalez, Carlos, Fernandez, Adolfo, Ginebra Molins, Maria Pau|||0000-0002-4700-5621, Lopez Esteban, Sonia
Formato: artículo
Fecha de publicación:2015
País:España
Recursos:Universitat Politècnica de Catalunya (UPC)
Repositorio:UPCommons. Portal del coneixement obert de la UPC
Idioma:inglés
OAI Identifier:oai:upcommons.upc.edu:2117/85880
Acesso em linha:https://hdl.handle.net/2117/85880
https://dx.doi.org/10.1177/0885328214547400
Access Level:acceso abierto
Palavra-chave:Bone cements
Zirconia
titanium
nanostructured
spark plasma sintering
biocompatibility
zirconia ceramics
3y-tzp/nb composites
joint replacement
dental implants
adhesion
differentiation
topography
surfaces
osseointegration
Ciments ossis
Àrees temàtiques de la UPC::Enginyeria dels materials
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spelling Osteoblastic cell response to spark plasma-sintered zirconia/titanium cermetsFernandez Garcia, ElisaGuillem Martí, Jordi|||0000-0003-0307-2221Gutierrez Gonzalez, CarlosFernandez, AdolfoGinebra Molins, Maria Pau|||0000-0002-4700-5621Lopez Esteban, SoniaBone cementsZirconiatitaniumnanostructuredspark plasma sinteringbiocompatibilityzirconia ceramics3y-tzp/nb compositesjoint replacementdental implantsadhesiontitaniumdifferentiationtopographysurfacesosseointegrationCiments ossisÀrees temàtiques de la UPC::Enginyeria dels materialsCeramic/metal composites, cermets, arise from the idea to combine the dissimilar properties in the pure materials. This work aims to study the biocompatibility of new micro-nanostructured 3Y-TZP/Ti materials with 25, 50 and 75vol.% Ti, which have been successfully obtained by spark slasma sintering technology, as well as to correlate their surface properties (roughness, wettability and chemical composition) with the osteoblastic cell response. All samples had isotropic and slightly waved microstructure, with sub-micrometric average roughness. Composites with 75vol.% Ti had the highest surface hydrophilicity. Surface chemical composition of the cermets correlated well with the relative amounts used for their fabrication. A cell viability rate over 80% dismissed any cytotoxicity risk due to manufacturing. Cell adhesion and early differentiation were significantly enhanced on materials containing the nanostructured 3Y-TZP phase. Proliferation and differentiation of SaOS-2 were significantly improved in their late-stage on the composite with 75vol.% Ti that, from the osseointegration standpoint, is presented as an excellent biomaterial for bone replacement. Thus, spark plasma sintering is consolidated as a suitable technology for manufacturing nanostructured biomaterials with enhanced bioactivity.Peer Reviewed20152015-01-0120162016-04-19journal articlehttp://purl.org/coar/resource_type/c_6501AMhttp://purl.org/coar/version/c_ab4af688f83e57aainfo:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/2117/85880https://dx.doi.org/10.1177/0885328214547400reponame:UPCommons. Portal del coneixement obert de la UPCinstname:Universitat Politècnica de Catalunya (UPC)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2http://creativecommons.org/licenses/by-nc-nd/3.0/es/info:eu-repo/semantics/openAccessoai:upcommons.upc.edu:2117/858802026-05-27T15:37:01Z
dc.title.none.fl_str_mv Osteoblastic cell response to spark plasma-sintered zirconia/titanium cermets
title Osteoblastic cell response to spark plasma-sintered zirconia/titanium cermets
spellingShingle Osteoblastic cell response to spark plasma-sintered zirconia/titanium cermets
Fernandez Garcia, Elisa
Bone cements
Zirconia
titanium
nanostructured
spark plasma sintering
biocompatibility
zirconia ceramics
3y-tzp/nb composites
joint replacement
dental implants
adhesion
titanium
differentiation
topography
surfaces
osseointegration
Ciments ossis
Àrees temàtiques de la UPC::Enginyeria dels materials
title_short Osteoblastic cell response to spark plasma-sintered zirconia/titanium cermets
title_full Osteoblastic cell response to spark plasma-sintered zirconia/titanium cermets
title_fullStr Osteoblastic cell response to spark plasma-sintered zirconia/titanium cermets
title_full_unstemmed Osteoblastic cell response to spark plasma-sintered zirconia/titanium cermets
title_sort Osteoblastic cell response to spark plasma-sintered zirconia/titanium cermets
dc.creator.none.fl_str_mv Fernandez Garcia, Elisa
Guillem Martí, Jordi|||0000-0003-0307-2221
Gutierrez Gonzalez, Carlos
Fernandez, Adolfo
Ginebra Molins, Maria Pau|||0000-0002-4700-5621
Lopez Esteban, Sonia
author Fernandez Garcia, Elisa
author_facet Fernandez Garcia, Elisa
Guillem Martí, Jordi|||0000-0003-0307-2221
Gutierrez Gonzalez, Carlos
Fernandez, Adolfo
Ginebra Molins, Maria Pau|||0000-0002-4700-5621
Lopez Esteban, Sonia
author_role author
author2 Guillem Martí, Jordi|||0000-0003-0307-2221
Gutierrez Gonzalez, Carlos
Fernandez, Adolfo
Ginebra Molins, Maria Pau|||0000-0002-4700-5621
Lopez Esteban, Sonia
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv Bone cements
Zirconia
titanium
nanostructured
spark plasma sintering
biocompatibility
zirconia ceramics
3y-tzp/nb composites
joint replacement
dental implants
adhesion
titanium
differentiation
topography
surfaces
osseointegration
Ciments ossis
Àrees temàtiques de la UPC::Enginyeria dels materials
topic Bone cements
Zirconia
titanium
nanostructured
spark plasma sintering
biocompatibility
zirconia ceramics
3y-tzp/nb composites
joint replacement
dental implants
adhesion
titanium
differentiation
topography
surfaces
osseointegration
Ciments ossis
Àrees temàtiques de la UPC::Enginyeria dels materials
description Ceramic/metal composites, cermets, arise from the idea to combine the dissimilar properties in the pure materials. This work aims to study the biocompatibility of new micro-nanostructured 3Y-TZP/Ti materials with 25, 50 and 75vol.% Ti, which have been successfully obtained by spark slasma sintering technology, as well as to correlate their surface properties (roughness, wettability and chemical composition) with the osteoblastic cell response. All samples had isotropic and slightly waved microstructure, with sub-micrometric average roughness. Composites with 75vol.% Ti had the highest surface hydrophilicity. Surface chemical composition of the cermets correlated well with the relative amounts used for their fabrication. A cell viability rate over 80% dismissed any cytotoxicity risk due to manufacturing. Cell adhesion and early differentiation were significantly enhanced on materials containing the nanostructured 3Y-TZP phase. Proliferation and differentiation of SaOS-2 were significantly improved in their late-stage on the composite with 75vol.% Ti that, from the osseointegration standpoint, is presented as an excellent biomaterial for bone replacement. Thus, spark plasma sintering is consolidated as a suitable technology for manufacturing nanostructured biomaterials with enhanced bioactivity.
publishDate 2015
dc.date.none.fl_str_mv 2015
2015-01-01
2016
2016-04-19
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
AM
http://purl.org/coar/version/c_ab4af688f83e57aa
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/2117/85880
https://dx.doi.org/10.1177/0885328214547400
url https://hdl.handle.net/2117/85880
https://dx.doi.org/10.1177/0885328214547400
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2

http://creativecommons.org/licenses/by-nc-nd/3.0/es/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2

http://creativecommons.org/licenses/by-nc-nd/3.0/es/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:UPCommons. Portal del coneixement obert de la UPC
instname:Universitat Politècnica de Catalunya (UPC)
instname_str Universitat Politècnica de Catalunya (UPC)
reponame_str UPCommons. Portal del coneixement obert de la UPC
collection UPCommons. Portal del coneixement obert de la UPC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,301603

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