Incorporation of chloramphenicol and captopril into poly(GL)-b-poly(GL-co-TMC-co-CL)-b-poly(GL) monofilar surgical sutures
Incorporation of chloramphenicol and captopril into coated and uncoated monofilament sutures was evaluated, as well as the derived bactericide and wound healing effects. To this end, a commercially available suture and an amorphous random copolymer constituted by trimethylene carbonate and lactide u...
| Autores: | , , , , , , |
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| Tipo de recurso: | artículo |
| Fecha de publicación: | 2017 |
| País: | España |
| Institución: | Universitat Politècnica de Catalunya (UPC) |
| Repositorio: | UPCommons. Portal del coneixement obert de la UPC |
| Idioma: | inglés |
| OAI Identifier: | oai:upcommons.upc.edu:2117/104122 |
| Acceso en línea: | https://hdl.handle.net/2117/104122 https://dx.doi.org/10.1002/app.44762 |
| Access Level: | acceso abierto |
| Palabra clave: | Chloramphenicol Captopril Anti-infective agents Wound healing Ferides i lesions Agents antiinfecciosos -- Ús terapèutic Àrees temàtiques de la UPC::Enginyeria química |
| Sumario: | Incorporation of chloramphenicol and captopril into coated and uncoated monofilament sutures was evaluated, as well as the derived bactericide and wound healing effects. To this end, a commercially available suture and an amorphous random copolymer constituted by trimethylene carbonate and lactide units were considered. The suture had a segmented architecture based on polyglycolide hard blocks and a soft block constituted by glycolide, trimethylene carbonate and ε-caprolactone units. Chloramphenicol was better loaded when the coating copolymer was employed due to its protective effect whereas captopril showed an opposite behavior due to partial solubilization during immersion in the coating bath. Interestingly, the release behavior was very different for the two studied drugs since a significant retention of chloramphenicol was always detected, suggesting the establishment of interactions between drug and copolymers. On the other hand, delivery of captopril showed a typical dose dependent behavior. A low in vitro toxicity of the two drugs was determined considering both epithelial-like and fibroblast-like cells. Bactericide effect of chloramphenicol against Gram-negative and Gram-positive bacteria was demonstrated at a dose that was non-toxic for all assayed cells. An accelerating wound healing effect of captopril was also demonstrated for early events. In this case, the use of a coating copolymer was fundamental to avoid cytotoxic effects on highly loaded sutures. |
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