Radiochromic film dosimetry for monitoring preclinical FLASH protontherapy experiments
In this work FLASH radiotherapy has been studied in a theoretical and experimental way. First, this work is based on a bibliographic research of the current state of the art. Secondly, the study is particularized on FLASH protontherapy. In this second part of the work, I conducted the dosimetry of a...
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| Formato: | tesis de maestría |
| Fecha de publicación: | 2020 |
| País: | España |
| Recursos: | Universidad Complutense de Madrid (UCM) |
| Repositorio: | Docta Complutense |
| Idioma: | inglés |
| OAI Identifier: | oai:docta.ucm.es:20.500.14352/9165 |
| Acesso em linha: | https://hdl.handle.net/20.500.14352/9165 |
| Access Level: | acceso abierto |
| Palavra-chave: | 539.1 FLASH radiotherapy FLASH effect Radiochromic films FLASH protontherapy Dosimetry Quenching effect Radioterapia FLASH Efecto FLASH Películas radiocrómicas Protonterapia FLASH Dosimetría Efecto quenching Física nuclear Oncología 2207 Física Atómica y Nuclear 3201.01 Oncología |
| Resumo: | In this work FLASH radiotherapy has been studied in a theoretical and experimental way. First, this work is based on a bibliographic research of the current state of the art. Secondly, the study is particularized on FLASH protontherapy. In this second part of the work, I conducted the dosimetry of a preclinical experiment made by the Group of Nuclear Physics (GFN) of Universidad Complutense de Madrid (UCM). In this experiment different samples were exposed to 3-MeV protons delivered with FLASH and conventional irradiation rates. The dosimetry of the experiment was performed with radiochromic (RC) films. This process required a prior calibration of the RC film to allow measurement of absolute dose during the experiment. The experiment also included characterization of the beam lateral spread. Furthermore, we conducted a theoretical study of the RC film dose response as a function of the linear energy transfer of protons, concluding that RC films show a dose under response in the proximity of Bragg peak (quenching effect). This theoretical study was verified with the measured beam profiles and a Monte Carlo simulation using TOPAS. |
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