Progression-free survival after front line, second line and third line in patients with follicular lymphoma treated in clinical practice

Background: The modern-day therapeutic landscape for follicular lymphoma (FL) includes a number of highly effective therapies. Patients and methods: We set out to determine progression-free survival (PFS) after front line, second line, and third line of therapy on the basis of relevant biological ch...

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Autores: Rajamäki, Aino, Sorigue, Marc|||0000-0002-0587-591X, Prusila, Roosa E.I., Kuusisto, Milla E.L., Kuitunen, Hanne, Jantunen, Esa, Mercadal, Santiago|||0000-0003-4741-7885, Turpeenniemi-Hujanen, Taina, Sancho, Juan Manuel, Sunela, Kaisa, Kuittinen, Outi
Tipo de recurso: artículo
Fecha de publicación:2024
País:España
Institución:Universitat Autònoma de Barcelona
Repositorio:Dipòsit Digital de Documents de la UAB
Idioma:inglés
OAI Identifier:oai:ddd.uab.cat:302160
Acceso en línea:https://ddd.uab.cat/record/302160
https://dx.doi.org/urn:doi:10.2340/1651-226X.2024.24377
Access Level:acceso abierto
Palabra clave:Follicular lymphoma
Survival
Progression-free
Treatment
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spelling Progression-free survival after front line, second line and third line in patients with follicular lymphoma treated in clinical practiceRajamäki, AinoSorigue, Marc|||0000-0002-0587-591XPrusila, Roosa E.I.Kuusisto, Milla E.L.Kuitunen, HanneJantunen, EsaMercadal, Santiago|||0000-0003-4741-7885Turpeenniemi-Hujanen, TainaSancho, Juan ManuelSunela, KaisaKuittinen, OutiFollicular lymphomaSurvivalProgression-freeSurvivalTreatmentBackground: The modern-day therapeutic landscape for follicular lymphoma (FL) includes a number of highly effective therapies. Patients and methods: We set out to determine progression-free survival (PFS) after front line, second line, and third line of therapy on the basis of relevant biological characteristics and therapeutic choices. Patients (n = 743, 51% females, median 60 years old) diagnosed with grade 1-2 FL between 1997 and 2016 in nine institutions were included. Results: The median PFS1, PFS2, and PFS3 were 8.1 years (95% confidence interval [CI]: 7-9.3 years), 4.2 years (95% CI: 2.8-5.6 years) and 2.2 years (95% CI 1.7-2.8 years). We found longer PFS1 for (1) females, (2) younger age, (3) lower-risk follicular lymphoma international prognostic index (FLIPI), (4) standard intensity (over low intensity) regimens and (5) immunochemotherapy strategies and (6) maintenance rituximab. We found a shorter PFS2 for patients who received front-line immunochemotherapy. Older age at diagnosis correlated with a shorter PFS3. Intensity of front-line chemotherapy, maintenance, or POD24 status did not correlate with PFS2 or PFS3 in this dataset. Interpretation: With current immunochemotherapy strategies, the natural course of FL is characterized by shorter-lasting remissions after each relapse. It will be interesting to see whether new therapies can alter this pattern. 22024-01-0120242024-01-01Articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://ddd.uab.cat/record/302160https://dx.doi.org/urn:doi:10.2340/1651-226X.2024.24377reponame:Dipòsit Digital de Documents de la UABinstname:Universitat Autònoma de BarcelonaInglésengopen accesshttp://purl.org/coar/access_right/c_abf2Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:ddd.uab.cat:3021602026-06-06T12:50:31Z
dc.title.none.fl_str_mv Progression-free survival after front line, second line and third line in patients with follicular lymphoma treated in clinical practice
title Progression-free survival after front line, second line and third line in patients with follicular lymphoma treated in clinical practice
spellingShingle Progression-free survival after front line, second line and third line in patients with follicular lymphoma treated in clinical practice
Rajamäki, Aino
Follicular lymphoma
Survival
Progression-free
Survival
Treatment
title_short Progression-free survival after front line, second line and third line in patients with follicular lymphoma treated in clinical practice
title_full Progression-free survival after front line, second line and third line in patients with follicular lymphoma treated in clinical practice
title_fullStr Progression-free survival after front line, second line and third line in patients with follicular lymphoma treated in clinical practice
title_full_unstemmed Progression-free survival after front line, second line and third line in patients with follicular lymphoma treated in clinical practice
title_sort Progression-free survival after front line, second line and third line in patients with follicular lymphoma treated in clinical practice
dc.creator.none.fl_str_mv Rajamäki, Aino
Sorigue, Marc|||0000-0002-0587-591X
Prusila, Roosa E.I.
Kuusisto, Milla E.L.
Kuitunen, Hanne
Jantunen, Esa
Mercadal, Santiago|||0000-0003-4741-7885
Turpeenniemi-Hujanen, Taina
Sancho, Juan Manuel
Sunela, Kaisa
Kuittinen, Outi
author Rajamäki, Aino
author_facet Rajamäki, Aino
Sorigue, Marc|||0000-0002-0587-591X
Prusila, Roosa E.I.
Kuusisto, Milla E.L.
Kuitunen, Hanne
Jantunen, Esa
Mercadal, Santiago|||0000-0003-4741-7885
Turpeenniemi-Hujanen, Taina
Sancho, Juan Manuel
Sunela, Kaisa
Kuittinen, Outi
author_role author
author2 Sorigue, Marc|||0000-0002-0587-591X
Prusila, Roosa E.I.
Kuusisto, Milla E.L.
Kuitunen, Hanne
Jantunen, Esa
Mercadal, Santiago|||0000-0003-4741-7885
Turpeenniemi-Hujanen, Taina
Sancho, Juan Manuel
Sunela, Kaisa
Kuittinen, Outi
author2_role author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Follicular lymphoma
Survival
Progression-free
Survival
Treatment
topic Follicular lymphoma
Survival
Progression-free
Survival
Treatment
description Background: The modern-day therapeutic landscape for follicular lymphoma (FL) includes a number of highly effective therapies. Patients and methods: We set out to determine progression-free survival (PFS) after front line, second line, and third line of therapy on the basis of relevant biological characteristics and therapeutic choices. Patients (n = 743, 51% females, median 60 years old) diagnosed with grade 1-2 FL between 1997 and 2016 in nine institutions were included. Results: The median PFS1, PFS2, and PFS3 were 8.1 years (95% confidence interval [CI]: 7-9.3 years), 4.2 years (95% CI: 2.8-5.6 years) and 2.2 years (95% CI 1.7-2.8 years). We found longer PFS1 for (1) females, (2) younger age, (3) lower-risk follicular lymphoma international prognostic index (FLIPI), (4) standard intensity (over low intensity) regimens and (5) immunochemotherapy strategies and (6) maintenance rituximab. We found a shorter PFS2 for patients who received front-line immunochemotherapy. Older age at diagnosis correlated with a shorter PFS3. Intensity of front-line chemotherapy, maintenance, or POD24 status did not correlate with PFS2 or PFS3 in this dataset. Interpretation: With current immunochemotherapy strategies, the natural course of FL is characterized by shorter-lasting remissions after each relapse. It will be interesting to see whether new therapies can alter this pattern.
publishDate 2024
dc.date.none.fl_str_mv 2
2024-01-01
2024
2024-01-01
dc.type.none.fl_str_mv Article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://ddd.uab.cat/record/302160
https://dx.doi.org/urn:doi:10.2340/1651-226X.2024.24377
url https://ddd.uab.cat/record/302160
https://dx.doi.org/urn:doi:10.2340/1651-226X.2024.24377
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Dipòsit Digital de Documents de la UAB
instname:Universitat Autònoma de Barcelona
instname_str Universitat Autònoma de Barcelona
reponame_str Dipòsit Digital de Documents de la UAB
collection Dipòsit Digital de Documents de la UAB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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