Protocol to assess rewarding brain stimulation as a learning and memory modulating treatment

Intracranial electrical self-stimulation (ICSS) is a useful procedure in animal research. This form of administration ensures that areas of the brain reward system (BRS) are being functionally activated, since the animals must perform an operant response to self-administer an electrical stimulus. Re...

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Autores: Vila-Solés, Laia, García-Brito, Soleil|||0000-0002-4292-3212, Aldavert Vera, Laura|||0000-0002-1506-4790, Kádár, Elisabet|||0000-0001-9135-4637, Huguet, Gemma|||0000-0002-1439-5053, Morgado-Bernal, Ignacio|||0000-0002-6008-7449, Segura Torres, Pilar|||0000-0001-6963-8625
Formato: artículo
Fecha de publicación:2022
País:España
Recursos:Universitat Autònoma de Barcelona
Repositorio:Dipòsit Digital de Documents de la UAB
Idioma:inglés
OAI Identifier:oai:ddd.uab.cat:270751
Acesso em linha:https://ddd.uab.cat/record/270751
https://dx.doi.org/urn:doi:10.3389/fnbeh.2022.1046259
Access Level:acceso abierto
Palavra-chave:Intracranial self-stimulation
Medial forebrain bundle (MFB)
Brain reward system
Learning
Memory
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spelling Protocol to assess rewarding brain stimulation as a learning and memory modulating treatmentComparison between self-administration and experimenter-administrationVila-Solés, LaiaGarcía-Brito, Soleil|||0000-0002-4292-3212Aldavert Vera, Laura|||0000-0002-1506-4790Kádár, Elisabet|||0000-0001-9135-4637Huguet, Gemma|||0000-0002-1439-5053Morgado-Bernal, Ignacio|||0000-0002-6008-7449Segura Torres, Pilar|||0000-0001-6963-8625Intracranial self-stimulationMedial forebrain bundle (MFB)Brain reward systemLearningMemoryIntracranial electrical self-stimulation (ICSS) is a useful procedure in animal research. This form of administration ensures that areas of the brain reward system (BRS) are being functionally activated, since the animals must perform an operant response to self-administer an electrical stimulus. Rewarding post-training ICSS of the medial forebrain bundle (MFB), an important system of the BRS, has been shown to consistently improve rats' acquisition and retention in several learning tasks. In the clinical setting, deep brain stimulation (DBS) of different targets is currently being used to palliate the memory impairment that occurs in some neurodegenerative diseases. However, the stimulation of the MFB has only been used to treat emotional alterations, not memory disorders. Since DBS stimulation treatments in humans are exclusively administered by external sources, studies comparing the efficacy of that form of application to a self-administered stimulation are key to the translationality of ICSS. This protocol compares self-administered (ICSS) and experimenter-administered (EAS) stimulation of the MFB on the spatial Morris Water Maze task (MWM). c-Fos immunohistochemistry procedure was carried out to evaluate neural activation after retention. Results show that the stimulation of the MFB improves the MWM task regardless of the form of administration, although some differences in c-Fos expression were found. Present results suggest that MFB-ICSS is a valid animal model to study the effects of MFB electrical stimulation on memory, which could guide clinical applications of DBS. The present protocol is a useful guide for establishing ICSS behavior in rats, which could be used as a learning and memory-modulating treatment. Comprehensive timeline of an experiment using self-administered or experimenter-administered intracranial stimulation to modulate learning and memory.Universitat Autònoma de Barcelona. Institut de Neurociències 22022-01-0120222022-01-01Articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://ddd.uab.cat/record/270751https://dx.doi.org/urn:doi:10.3389/fnbeh.2022.1046259reponame:Dipòsit Digital de Documents de la UABinstname:Universitat Autònoma de BarcelonaInglésengAgencia Estatal de Investigación https://doi.org/10.13039/501100011033 PID2020-117101RB-C21Agencia Estatal de Investigación https://doi.org/10.13039/501100011033 PID2020-117101RB-C22open accesshttp://purl.org/coar/access_right/c_abf2Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:ddd.uab.cat:2707512026-06-06T12:50:31Z
dc.title.none.fl_str_mv Protocol to assess rewarding brain stimulation as a learning and memory modulating treatment
Comparison between self-administration and experimenter-administration
title Protocol to assess rewarding brain stimulation as a learning and memory modulating treatment
spellingShingle Protocol to assess rewarding brain stimulation as a learning and memory modulating treatment
Vila-Solés, Laia
Intracranial self-stimulation
Medial forebrain bundle (MFB)
Brain reward system
Learning
Memory
title_short Protocol to assess rewarding brain stimulation as a learning and memory modulating treatment
title_full Protocol to assess rewarding brain stimulation as a learning and memory modulating treatment
title_fullStr Protocol to assess rewarding brain stimulation as a learning and memory modulating treatment
title_full_unstemmed Protocol to assess rewarding brain stimulation as a learning and memory modulating treatment
title_sort Protocol to assess rewarding brain stimulation as a learning and memory modulating treatment
dc.creator.none.fl_str_mv Vila-Solés, Laia
García-Brito, Soleil|||0000-0002-4292-3212
Aldavert Vera, Laura|||0000-0002-1506-4790
Kádár, Elisabet|||0000-0001-9135-4637
Huguet, Gemma|||0000-0002-1439-5053
Morgado-Bernal, Ignacio|||0000-0002-6008-7449
Segura Torres, Pilar|||0000-0001-6963-8625
author Vila-Solés, Laia
author_facet Vila-Solés, Laia
García-Brito, Soleil|||0000-0002-4292-3212
Aldavert Vera, Laura|||0000-0002-1506-4790
Kádár, Elisabet|||0000-0001-9135-4637
Huguet, Gemma|||0000-0002-1439-5053
Morgado-Bernal, Ignacio|||0000-0002-6008-7449
Segura Torres, Pilar|||0000-0001-6963-8625
author_role author
author2 García-Brito, Soleil|||0000-0002-4292-3212
Aldavert Vera, Laura|||0000-0002-1506-4790
Kádár, Elisabet|||0000-0001-9135-4637
Huguet, Gemma|||0000-0002-1439-5053
Morgado-Bernal, Ignacio|||0000-0002-6008-7449
Segura Torres, Pilar|||0000-0001-6963-8625
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universitat Autònoma de Barcelona. Institut de Neurociències
dc.subject.none.fl_str_mv Intracranial self-stimulation
Medial forebrain bundle (MFB)
Brain reward system
Learning
Memory
topic Intracranial self-stimulation
Medial forebrain bundle (MFB)
Brain reward system
Learning
Memory
description Intracranial electrical self-stimulation (ICSS) is a useful procedure in animal research. This form of administration ensures that areas of the brain reward system (BRS) are being functionally activated, since the animals must perform an operant response to self-administer an electrical stimulus. Rewarding post-training ICSS of the medial forebrain bundle (MFB), an important system of the BRS, has been shown to consistently improve rats' acquisition and retention in several learning tasks. In the clinical setting, deep brain stimulation (DBS) of different targets is currently being used to palliate the memory impairment that occurs in some neurodegenerative diseases. However, the stimulation of the MFB has only been used to treat emotional alterations, not memory disorders. Since DBS stimulation treatments in humans are exclusively administered by external sources, studies comparing the efficacy of that form of application to a self-administered stimulation are key to the translationality of ICSS. This protocol compares self-administered (ICSS) and experimenter-administered (EAS) stimulation of the MFB on the spatial Morris Water Maze task (MWM). c-Fos immunohistochemistry procedure was carried out to evaluate neural activation after retention. Results show that the stimulation of the MFB improves the MWM task regardless of the form of administration, although some differences in c-Fos expression were found. Present results suggest that MFB-ICSS is a valid animal model to study the effects of MFB electrical stimulation on memory, which could guide clinical applications of DBS. The present protocol is a useful guide for establishing ICSS behavior in rats, which could be used as a learning and memory-modulating treatment. Comprehensive timeline of an experiment using self-administered or experimenter-administered intracranial stimulation to modulate learning and memory.
publishDate 2022
dc.date.none.fl_str_mv 2
2022-01-01
2022
2022-01-01
dc.type.none.fl_str_mv Article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://ddd.uab.cat/record/270751
https://dx.doi.org/urn:doi:10.3389/fnbeh.2022.1046259
url https://ddd.uab.cat/record/270751
https://dx.doi.org/urn:doi:10.3389/fnbeh.2022.1046259
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.relation.none.fl_str_mv Agencia Estatal de Investigación https://doi.org/10.13039/501100011033 PID2020-117101RB-C21
Agencia Estatal de Investigación https://doi.org/10.13039/501100011033 PID2020-117101RB-C22
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Dipòsit Digital de Documents de la UAB
instname:Universitat Autònoma de Barcelona
instname_str Universitat Autònoma de Barcelona
reponame_str Dipòsit Digital de Documents de la UAB
collection Dipòsit Digital de Documents de la UAB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,301603

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