Clinical Outcomes and Quality of Life in Older De Novo Kidney Transplant Recipients Under Once‐Daily Tacrolimus Formulations: The BITACORA Study

ABSTRACT Introduction Although advanced age is no longer a contraindication for renal transplantation, real‐world data on elderly transplant recipients remain limited. Methods This multicenter, prospective study enrolled de novo kidney transplant recipients aged 60 years or older receiving once‐dail...

Descripción completa

Detalles Bibliográficos
Autores: Andrés, Amado, Jiménez, Sara, Aladrén Regidor, Maria José, Moreso, Francesc, Crespo, Marta, Serra Cabañas, Nuria, Gómez Marqués, Gonzalo, López, Verónica, Carmen Díaz Corte, Maria del, Fraile‐Gómez, Pilar, Lorenzo, Inmaculada, Ruiz San Millán, Juan Carlos, Cañas, Laura, Rodríguez Benot, Alberto, Calvo Romero, Natividad, Diekmann, Fritz, Mendiluce, Alicia, Fernández Rivera, Constantino, Gallego, Roberto, Jiménez, Carlos, Martin‐Moreno, Paloma L., Fernández Tagarro, Ernesto, Díaz, Cándido, Martín Urcuyo, Basilio, González Roncero, Francisco Manuel
Tipo de recurso: artículo
Fecha de publicación:2026
País:España
Institución:Conselleria de Salut i Consum del Govern de les Illes Balears
Repositorio:Docusalut
Idioma:inglés
OAI Identifier:oai:docusalut.com:20.500.13003/26838
Acceso en línea:https://hdl.handle.net/20.500.13003/26838
Access Level:acceso abierto
Palabra clave:Aged
Female
Follow-Up Studies
Glomerular Filtration Rate
Graft Rejection
Graft Survival
Humans
Immunosuppressive Agents
Kidney Failure, Chronic
Kidney Function Tests
Kidney Transplantation
Male
Middle Aged
Postoperative Complications
Prognosis
Prospective Studies
Quality of Life
Risk Factors
Tacrolimus
Anciano
Femenino
Estudios de Seguimiento
Tasa de Filtración Glomerular
Rechazo de Injerto
Supervivencia de Injerto
Humanos
Inmunosupresores
Fallo Renal Crónico
Pruebas de Función Renal
Trasplante de Riñón
Masculino
Persona de Mediana Edad
Complicaciones Posoperatorias
Pronóstico
Estudios Prospectivos
Calidad de Vida
Factores de Riesgo
elderly
kidney transplant
rejection
tacrolimus
Descripción
Sumario:ABSTRACT Introduction Although advanced age is no longer a contraindication for renal transplantation, real‐world data on elderly transplant recipients remain limited. Methods This multicenter, prospective study enrolled de novo kidney transplant recipients aged 60 years or older receiving once‐daily tacrolimus immunosuppression, following recovery of renal function and referral to the transplant clinic. The primary objective was to describe clinical characteristics and post‐transplant outcomes over a 12‐month follow‐up. Secondary objectives included assessing changes in quality of life and the relationship between biopsy‐proven acute rejection (BPAR) and tacrolimus levels. Results Of 280 evaluable patients, 239 completed the 12‐month follow‐up (mean recipient age: 69.8 years; mean donor age: 69.1 years) and 41 (14.6%) terminated due to graft loss (13, 31.7%), tacrolimus termination (12, 29.3%), death (10, 24.4%), loss to follow‐up (3, 7.3%), other (2, 4.9%), and temporary tacrolimus interruption (1, 2.4%). BPAR occurred in 8.2% of patients who showed significantly higher tacrolimus levels vs those without BPAR over the follow‐up (9.8 ng/mL vs. 8.9 ng/mL; p = 0.01). Opportunistic infections were reported in 78.3% patients with BPAR vs 58.8% without BPAR ( p = 0.07). Quality of life improved across different domains of the Kidney Transplant Questionnaire and the ESRD‐SCL. Conclusion This study monitored clinical outcomes during the first year post‐transplant in older de novo kidney transplant recipients receiving grafts from older donors and under a once‐daily tacrolimus‐based immunosuppressive regimen. The incidence of BPAR, graft loss, and mortality was low, and patients generally experienced an improvement in quality of life, indicating an effective and safe procedure in this population.

Similares en LA Referencia