Metabolomics for Biomarkers of Type 2 Diabetes Mellitus: Advances and Nutritional Intervention Trends

Abstract Metabolic characterization of type 2 diabetes mellitus (T2DM) is crucial for the identification of individuals at risk for developing diabetes and T2DM-related vascular complications as well as for monitoring disease progression. The application of metabolomics to diabetes research may lead...

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Autores: Urpí Sardà, Mireia, Almanza Aguilera, Enrique, Tulipani, Sara, Tinahones, Francisco J., Salas Salvadó, Jordi, Andrés Lacueva, Ma. Cristina
Formato: artículo
Estado:Versión aceptada para publicación
Fecha de publicación:2015
País:España
Recursos:Universidad de Barcelona
Repositorio:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/169101
Acesso em linha:https://hdl.handle.net/2445/169101
Access Level:acceso abierto
Palavra-chave:Diabetis
Obesitat
Metabolisme
Diabetes
Obesity
Metabolism
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spelling Metabolomics for Biomarkers of Type 2 Diabetes Mellitus: Advances and Nutritional Intervention TrendsUrpí Sardà, MireiaAlmanza Aguilera, EnriqueTulipani, SaraTinahones, Francisco J.Salas Salvadó, JordiAndrés Lacueva, Ma. CristinaDiabetisObesitatMetabolismeDiabetesObesityMetabolismAbstract Metabolic characterization of type 2 diabetes mellitus (T2DM) is crucial for the identification of individuals at risk for developing diabetes and T2DM-related vascular complications as well as for monitoring disease progression. The application of metabolomics to diabetes research may lead to the identification and discovery of diagnostic and prognostic T2DM biomarkers, in addition to elucidating disease pathways. In the present review, we summarize the distinct classes of metabolites that have been proposed as potential biomarkers for progressing stages of T2DM by metabolomic approaches. Several studies have demonstrated that the metabolism of carbohydrates, lipids, and amino acids is considerably altered in prediabetes and continue to vary over the course of T2DM progression. The identification of intermediate metabolites involved in glycolysis, gluconeogenesis, the tricarboxylic acid cycle, lipolysis, and proteolysis have provided evidence of these metabolic dysfunctions. Finally, given the increasing worldwide incidence of T2DM and its related complications, research should focus on the impact of lifestyle factors, particularly diet, at the metabolomic level for better understanding and improved healthcare strategiesSpringer Nature2015info:eu-repo/semantics/articleinfo:eu-repo/semantics/acceptedVersionapplication/pdfhttps://hdl.handle.net/2445/169101Articles publicats en revistes (Nutrició, Ciències de l'Alimentació i Gastronomia)reponame:Dipòsit Digital de la UBinstname:Universidad de BarcelonaInglésVersió postprint del document publicat a:Current Cardiovascular Risk Reports, 2015, vol. 9, num. 12(c) Springer Nature, 2015info:eu-repo/semantics/openAccessoai:diposit.ub.edu:2445/1691012026-05-27T06:46:51Z
dc.title.none.fl_str_mv Metabolomics for Biomarkers of Type 2 Diabetes Mellitus: Advances and Nutritional Intervention Trends
title Metabolomics for Biomarkers of Type 2 Diabetes Mellitus: Advances and Nutritional Intervention Trends
spellingShingle Metabolomics for Biomarkers of Type 2 Diabetes Mellitus: Advances and Nutritional Intervention Trends
Urpí Sardà, Mireia
Diabetis
Obesitat
Metabolisme
Diabetes
Obesity
Metabolism
title_short Metabolomics for Biomarkers of Type 2 Diabetes Mellitus: Advances and Nutritional Intervention Trends
title_full Metabolomics for Biomarkers of Type 2 Diabetes Mellitus: Advances and Nutritional Intervention Trends
title_fullStr Metabolomics for Biomarkers of Type 2 Diabetes Mellitus: Advances and Nutritional Intervention Trends
title_full_unstemmed Metabolomics for Biomarkers of Type 2 Diabetes Mellitus: Advances and Nutritional Intervention Trends
title_sort Metabolomics for Biomarkers of Type 2 Diabetes Mellitus: Advances and Nutritional Intervention Trends
dc.creator.none.fl_str_mv Urpí Sardà, Mireia
Almanza Aguilera, Enrique
Tulipani, Sara
Tinahones, Francisco J.
Salas Salvadó, Jordi
Andrés Lacueva, Ma. Cristina
author Urpí Sardà, Mireia
author_facet Urpí Sardà, Mireia
Almanza Aguilera, Enrique
Tulipani, Sara
Tinahones, Francisco J.
Salas Salvadó, Jordi
Andrés Lacueva, Ma. Cristina
author_role author
author2 Almanza Aguilera, Enrique
Tulipani, Sara
Tinahones, Francisco J.
Salas Salvadó, Jordi
Andrés Lacueva, Ma. Cristina
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv Diabetis
Obesitat
Metabolisme
Diabetes
Obesity
Metabolism
topic Diabetis
Obesitat
Metabolisme
Diabetes
Obesity
Metabolism
description Abstract Metabolic characterization of type 2 diabetes mellitus (T2DM) is crucial for the identification of individuals at risk for developing diabetes and T2DM-related vascular complications as well as for monitoring disease progression. The application of metabolomics to diabetes research may lead to the identification and discovery of diagnostic and prognostic T2DM biomarkers, in addition to elucidating disease pathways. In the present review, we summarize the distinct classes of metabolites that have been proposed as potential biomarkers for progressing stages of T2DM by metabolomic approaches. Several studies have demonstrated that the metabolism of carbohydrates, lipids, and amino acids is considerably altered in prediabetes and continue to vary over the course of T2DM progression. The identification of intermediate metabolites involved in glycolysis, gluconeogenesis, the tricarboxylic acid cycle, lipolysis, and proteolysis have provided evidence of these metabolic dysfunctions. Finally, given the increasing worldwide incidence of T2DM and its related complications, research should focus on the impact of lifestyle factors, particularly diet, at the metabolomic level for better understanding and improved healthcare strategies
publishDate 2015
dc.date.none.fl_str_mv 2015
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/acceptedVersion
format article
status_str acceptedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/169101
url https://hdl.handle.net/2445/169101
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Versió postprint del document publicat a:
Current Cardiovascular Risk Reports, 2015, vol. 9, num. 12
dc.rights.none.fl_str_mv (c) Springer Nature, 2015
info:eu-repo/semantics/openAccess
rights_invalid_str_mv (c) Springer Nature, 2015
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Springer Nature
publisher.none.fl_str_mv Springer Nature
dc.source.none.fl_str_mv Articles publicats en revistes (Nutrició, Ciències de l'Alimentació i Gastronomia)
reponame:Dipòsit Digital de la UB
instname:Universidad de Barcelona
instname_str Universidad de Barcelona
reponame_str Dipòsit Digital de la UB
collection Dipòsit Digital de la UB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,300724

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